The Decapentaplegic morphogen gradient: a precise definition.

abstract：:Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a ...

journal_title：Current opinion in cell biology

authors： Mellad JA,Warren DT,Shanahan CM

更新日期：2011-02-01 00:00:00

abstract：:Recently, DAP-kinase was identified as one of the essential regulators of autophagy, activated by signals such as cytokines and ER stress. DAP-kinase is a tumor suppressor that mediates several cell death pathways, such as apoptosis and programmed necrosis. Likewise, functional studies suggest that DAP-kinase may dire...

journal_title：Current opinion in cell biology

authors： Bialik S,Kimchi A

更新日期：2010-04-01 00:00:00

abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...

journal_title：Current opinion in cell biology

authors： Suter DM,Molina N,Naef F,Schibler U

更新日期：2011-12-01 00:00:00

abstract：:Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of p...

journal_title：Current opinion in cell biology

authors： Rolland SG,Conradt B

更新日期：2010-12-01 00:00:00

abstract：:Actin filament assembly is a tightly regulated process that functions in many aspects of cell physiology. Members of the Ena/VASP (Drosophila Enabled/vasodilator-stimulated phosphoprotein) family are key players in regulating actin filament assembly, in many cases through their association with binding partners that d...

journal_title：Current opinion in cell biology

authors： Renfranz PJ,Beckerle MC

更新日期：2002-02-01 00:00:00

abstract：:A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Cell Biology. ...

journal_title：Current opinion in cell biology

authors： Pines J,Lafont F

更新日期：2001-08-01 00:00:00

abstract：:Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal...

journal_title：Current opinion in cell biology

authors： Joshi CV,Enver T

更新日期：2002-12-01 00:00:00

abstract：:Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

journal_title：Current opinion in cell biology

authors： Suganuma T,Workman JL

更新日期：2013-06-01 00:00:00

abstract：:Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and ...

journal_title：Current opinion in cell biology

authors： Hasson T,Cheney RE

更新日期：2001-02-01 00:00:00

abstract：:Recent advances in several key areas of fibronectin biology are discussed. These include its expression, from transcription to secretion of dimers, the structural requirements for several of the binding activities, potential roles for alternatively spliced segments in cell adhesion, and the assembly of a fibronectin m...

journal_title：Current opinion in cell biology

authors： Schwarzbauer JE

更新日期：1991-10-01 00:00:00

abstract：:The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...

journal_title：Current opinion in cell biology

authors： Ringrose L

更新日期：2007-06-01 00:00:00

abstract：:Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiologi...

journal_title：Current opinion in cell biology

authors： Lee S,Christakos S,Small MB

更新日期：1993-04-01 00:00:00

abstract：:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...

journal_title：Current opinion in cell biology

authors： Kohlmaier A,Edgar BA

更新日期：2008-12-01 00:00:00

abstract：:Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establ...

journal_title：Current opinion in cell biology

authors： Zhu M,Zernicka-Goetz M

更新日期：2020-02-01 00:00:00

abstract：:The past several years have seen major advances in our understanding of the mechanisms of microtubule destabilization by oncoprotein18/stathmin (Op18/stathmin) and related proteins. New structural information has clearly shown how members of the Op18/stathmin protein family bind tubulin dimers and suggests models for ...

journal_title：Current opinion in cell biology

authors： Cassimeris L

更新日期：2002-02-01 00:00:00

abstract：:Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial ...

journal_title：Current opinion in cell biology

authors： Franz A,Kevei É,Hoppe T

更新日期：2015-12-01 00:00:00

abstract：:Senescence represents a permanent exit from the cell cycle and its role in curtailing the proliferation of damaged and potentially oncogenic cells has relevance both as a front-line defense against cancer and as an underlying cause of aging. The retinoblastoma protein (RB) and p53 tumor suppressors are central to the ...

journal_title：Current opinion in cell biology

authors： Chandler H,Peters G

更新日期：2013-12-01 00:00:00

abstract：:The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and th...

journal_title：Current opinion in cell biology

authors： Herman IM

更新日期：1993-02-01 00:00:00

abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...

journal_title：Current opinion in cell biology

authors： Brown NH

更新日期：2000-10-01 00:00:00

abstract：:Flowers and shoots are derived from specialized groups of stem cells termed meristems. Recent studies in Arabidopsis have identified factors that contribute to meristem structure and identity, such as CLAVATA1, CLAVATA3, and SHOOTMERISTEMLESS, which act in both shoot and flower meristems, as well as LEAFY and APETALA1...

journal_title：Current opinion in cell biology

authors： Liljegren SJ,Yanofsky MF

更新日期：1996-12-01 00:00:00

abstract：:New structural analyses of the spectrin family of actin cross-linking proteins are providing molecular explanations for both the interchain binding between the alpha and beta chains of spectrin and the intermolecular associations between spectrin and other proteins. Additionally, the analyses bring into focus a confor...

journal_title：Current opinion in cell biology

authors： Viel A,Branton D

更新日期：1996-02-01 00:00:00

abstract：:Commitment to division requires that cells sense, interpret, and respond appropriately to multiple signals. In most eukaryotes, cells commit to division in G1 before DNA replication. Beyond a point, known as Start in yeast and the restriction point in mammals, cells will proceed through the cell cycle despite changes ...

journal_title：Current opinion in cell biology

authors： Johnson A,Skotheim JM

更新日期：2013-12-01 00:00:00

abstract：:New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and ret...

journal_title：Current opinion in cell biology

authors： Stevaux O,Dyson NJ

更新日期：2002-12-01 00:00:00

abstract：:Genetic analysis in model organisms has recently achieved a detailed molecular description of many key cellular processes controlling embryonic morphogenesis. To understand higher order tissue morphogenesis, we now need to define how these processes become integrated across different cell groups and cell layers. Here,...

journal_title：Current opinion in cell biology

authors： Zhang H,Gally C,Labouesse M

更新日期：2010-10-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hier...

journal_title：Current opinion in cell biology

authors： Roskelley CD,Srebrow A,Bissell MJ

更新日期：1995-10-01 00:00:00

abstract：:Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have re...

journal_title：Current opinion in cell biology

authors： van der Zand A,Tabak HF

更新日期：2013-08-01 00:00:00

abstract：:The histones which pack new DNA during the S phase of animal cells are made from mRNAs that are cleaved at their 3' end but not polyadenylated. Some of the factors used in this reaction are unique to it while others are shared with the polyadenylation process that generates all other mRNAs. Recent work has begun to sh...

journal_title：Current opinion in cell biology

authors： Romeo V,Schümperli D

更新日期：2016-06-01 00:00:00

abstract：:A key difference between yeast and metazoans is the need of the latter to regulate cell proliferation and growth to create organs (and organisms) of reproducible size and shape. Great progress has been made in understanding how growth, cell size and the cell cycle are controlled in metazoans. Recent work has shown tha...

journal_title：Current opinion in cell biology

authors： Leevers SJ,McNeill H

更新日期：2005-12-01 00:00:00

abstract：:The shaping of the vertebrate embryonic body plan depends heavily on the narrowing and lengthening (convergence and extension) of embryonic tissues by cell intercalation, a process by which cells actively crawl between one another along the axis of convergence to produce a narrower, longer array. We discuss recent evi...

journal_title：Current opinion in cell biology

authors： Skoglund P,Keller R

更新日期：2010-10-01 00:00:00