New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics.

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...

journal_title：Current opinion in cell biology

authors： Yun K,Wold B

更新日期：1996-12-01 00:00:00

abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...

journal_title：Current opinion in cell biology

authors： Verhey KJ,Yang W

更新日期：2016-08-01 00:00:00

abstract：:Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

journal_title：Current opinion in cell biology

authors： Suganuma T,Workman JL

更新日期：2013-06-01 00:00:00

abstract：:Autophagy is a crucial component of the cellular stress adaptation response that maintains mammalian homeostasis. Autophagy protects against neurodegenerative and inflammatory conditions, aging, and cancer. This is accomplished by the degradation and intracellular recycling of cellular components to maintain energy me...

journal_title：Current opinion in cell biology

authors： White E,Karp C,Strohecker AM,Guo Y,Mathew R

更新日期：2010-04-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold o...

journal_title：Current opinion in cell biology

authors： Fernandez-Martinez J,Rout MP

更新日期：2009-08-01 00:00:00

abstract：:Cell adhesion occurs via a highly regulated set of sequential interactions. Prototypic components of a variety of adhesion cascades are discussed, including integrins, triggering molecules and lectin-carbohydrate interactions. Selectivity and efficiency are achieved by utilizing the right combination of multiple adhes...

journal_title：Current opinion in cell biology

authors： Schweighoffer T,Shaw S

更新日期：1992-10-01 00:00:00

abstract：:How linear DNA molecules are packaged into compact cylindrical chromosomes in preparation for cell division has remained one of the central outstanding questions in cell biology. Condensin is a highly conserved protein complex that universally determines large-scale DNA geometry during mitotic chromosome assembly. A w...

journal_title：Current opinion in cell biology

authors： Takahashi M,Hirota T

更新日期：2019-10-01 00:00:00

abstract：:Branching morphogenesis is a widely used strategy to increase the surface area of a given organ. A number of tissues undergo branching morphogenesis during development, including the lung, kidney, vascular system and numerous glands. Until recently, very little has been known about the genetic principles underlying th...

journal_title：Current opinion in cell biology

authors： Affolter M,Shilo BZ

更新日期：2000-12-01 00:00:00

abstract：:When PI3Ks are deregulated by aberrant surface receptors or modulators, accumulation of PtdIns(3,4,5)P3 leads to increased cell growth, proliferation and contact-independent survival. The PI3K/PKB/TOR axis controls protein synthesis and growth, while PtdIns(3,4,5)P3-mediated activation of Rho GTPases directs cell moti...

journal_title：Current opinion in cell biology

authors： Wymann MP,Marone R

更新日期：2005-04-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...

journal_title：Current opinion in cell biology

authors： Capetanaki Y,Papathanasiou S,Diokmetzidou A,Vatsellas G,Tsikitis M

更新日期：2015-02-01 00:00:00

abstract：:Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the...

journal_title：Current opinion in cell biology

authors： Nicchitta CV

更新日期：2002-08-01 00:00:00

abstract：:A defining feature of eukaryotic cells is the nucleus, which houses the genome inside the nuclear envelope (NE): a double lipid bilayer that separates the nuclear and cytoplasmic materials. Although the NE is commonly viewed as a barrier that is overcome only by embedded nuclear pore complexes (NPCs) that facilitate n...

journal_title：Current opinion in cell biology

authors： Smoyer CJ,Jaspersen SL

更新日期：2014-02-01 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is the main endocytic pathway supporting housekeeping functions in cells. However, CME may be too slow to internalize proteins from the cell surface during certain physiological processes such as reaction to stress hormones ('fight-or-flight' reaction), chemotaxis or compensatory en...

journal_title：Current opinion in cell biology

authors： Watanabe S,Boucrot E

更新日期：2017-08-01 00:00:00

abstract：:There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while exclud...

journal_title：Current opinion in cell biology

authors： Harder T,Simons K

更新日期：1997-08-01 00:00:00

abstract：:The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities. This is achieved by modulating the dynamic properties of mit...

journal_title：Current opinion in cell biology

authors： Hoppins S

更新日期：2014-08-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosom...

journal_title：Current opinion in cell biology

authors： Tanaka TU

更新日期：2002-06-01 00:00:00

abstract：:1990 has been a year of continued exciting developments in cell cycle control. Progress has occurred in delineating the mechanism of activation of maturation-promoting factor during entry into mitosis and the mechanism of cyclin degradation responsible for exit from mitosis. Notable advances have also occurred in our ...

journal_title：Current opinion in cell biology

authors： Maller JL

更新日期：1991-04-01 00:00:00

abstract：:It is during gastrulation that the primordial germ layers are specified, embryonic axes become morphologically manifest, and the embryonic body plan begins to take shape. As morphogenetic movements push and pull nascent tissues into position within the gastrula, new interactions are established between neighboring cel...

journal_title：Current opinion in cell biology

authors： Williams ML,Solnica-Krezel L

更新日期：2017-10-01 00:00:00

abstract：:Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship betw...

journal_title：Current opinion in cell biology

authors： Weber SC

更新日期：2017-06-01 00:00:00

abstract：:Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial ...

journal_title：Current opinion in cell biology

authors： Franz A,Kevei É,Hoppe T

更新日期：2015-12-01 00:00:00

abstract：:Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telome...

journal_title：Current opinion in cell biology

authors： Price CM

更新日期：1992-06-01 00:00:00

abstract：:The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously un...

journal_title：Current opinion in cell biology

authors： Castelnuovo M,Stutz F

更新日期：2015-06-01 00:00:00

abstract：:The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into ...

journal_title：Current opinion in cell biology

authors： Goodell MA

更新日期：2001-12-01 00:00:00

abstract：:The assembly of intermediate filament (IF) arrays involves the recruitment of a complex set of cell-type-specific IF-associated proteins. Some of them are integral membrane proteins, others act as crosslinking proteins with vectorial binding activities, and yet others comprise motor proteins. In vivo IFs appear to be ...

journal_title：Current opinion in cell biology

authors： Herrmann H,Aebi U

更新日期：2000-02-01 00:00:00

abstract：:A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Cell Biology. ...

journal_title：Current opinion in cell biology

authors： Pines J,Lafont F

更新日期：2001-08-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:Several lines of evidence indicate that the lipids in the plasma membrane of animal cells are inhomogeneously distributed, and that various types of specialized lipid domains play an important role in many biological processes. The characteristics of these domains, such as size, composition and dynamics, are currently...

journal_title：Current opinion in cell biology

authors： Maxfield FR

更新日期：2002-08-01 00:00:00