Genetic control of branching morphogenesis during Drosophila tracheal development.

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...

journal_title：Current opinion in cell biology

authors： Weinberg ZY,Crilly SE,Puthenveedu MA

更新日期：2019-04-01 00:00:00

abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...

journal_title：Current opinion in cell biology

authors： Suter DM,Molina N,Naef F,Schibler U

更新日期：2011-12-01 00:00:00

abstract：:The materials cells are made of are strikingly different from man-made materials. Metabolism keeps cells out of equilibrium. Motor proteins and energy-consuming polymerization drive shape changes and motion. In contrast to macroscopic machines, though, there is no clear distinction between the force generators and the...

journal_title：Current opinion in cell biology

authors： Mackintosh FC,Schmidt CF

更新日期：2010-02-01 00:00:00

abstract：:The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)protein...

journal_title：Current opinion in cell biology

authors： Wassarman PM

更新日期：1995-10-01 00:00:00

abstract：:Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have...

journal_title：Current opinion in cell biology

authors： Sternweis PC

更新日期：1994-04-01 00:00:00

abstract：:The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become ...

journal_title：Current opinion in cell biology

authors： Hastings ML,Krainer AR

更新日期：2001-06-01 00:00:00

abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...

journal_title：Current opinion in cell biology

authors： Janicki SM,Spector DL

更新日期：2003-04-01 00:00:00

abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...

journal_title：Current opinion in cell biology

authors： Verhey KJ,Yang W

更新日期：2016-08-01 00:00:00

abstract：:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors i...

journal_title：Current opinion in cell biology

authors： Hakes AE,Brand AH

更新日期：2019-10-01 00:00:00

abstract：:Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a ...

journal_title：Current opinion in cell biology

authors： Mellad JA,Warren DT,Shanahan CM

更新日期：2011-02-01 00:00:00

abstract：:Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid...

journal_title：Current opinion in cell biology

authors： Strating JR,van Kuppeveld FJ

更新日期：2017-08-01 00:00:00

abstract：:The zebrafish is rapidly increasing in popularity with developmental biologists. Driving this interest are the elegant methods for in vivo observations and recovery of early developmental mutations. The past year has seen the introduction of additional methods for in vivo manipulation of identified cells and the appli...

journal_title：Current opinion in cell biology

authors： Fulwiler C,Gilbert W

更新日期：1991-12-01 00:00:00

abstract：:It is widely acknowledged that integrins, the major receptors for the extracellular matrix (ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors. Among them, growth factor receptors, such as the EGFR, MET, PDGFR and VEGFR, and the IL-3 receptor have been shown to be physically and...

journal_title：Current opinion in cell biology

authors： Brizzi MF,Tarone G,Defilippi P

更新日期：2012-10-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:Chaperones are centrally involved in the control of protein structure, function, localization and transport. A flurry of scientific activity continues to examine the molecular nature of chaperone-substrate recognition and the role of auxiliary chaperones (cohort proteins) and small molecules that expedite these proces...

journal_title：Current opinion in cell biology

authors： Kelley WL,Georgopoulos C

更新日期：1992-12-01 00:00:00

abstract：:The study of eukaryotic telomeres at the molecular level began with the discovery of short, tandem repeats at Tetrahymena chromosome ends. In the following two decades, major insights about telomere structure and function have come from investigations of telomerase, the DNA polymerase that synthesizes these repeats. I...

journal_title：Current opinion in cell biology

authors： Collins K

更新日期：1996-06-01 00:00:00

abstract：:As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...

journal_title：Current opinion in cell biology

authors： Zen K,Parkos CA

更新日期：2003-10-01 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau pro...

journal_title：Current opinion in cell biology

authors： Semenza GL

更新日期：2001-04-01 00:00:00

abstract：:Antigen processing leads to binding of antigenic peptides to major histocompatibility complex (MHC) molecules, and these peptide-MHC complexes are recognized by T cells. The class I and class II MHC antigen processing pathways employ different mechanisms and patterns of intracellular transport that allow the two class...

journal_title：Current opinion in cell biology

authors： Harding CV,Geuze HJ

更新日期：1993-08-01 00:00:00

abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...

journal_title：Current opinion in cell biology

authors： Hasson T,Mooseker MS

更新日期：1995-08-01 00:00:00

abstract：:Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, pha...

journal_title：Current opinion in cell biology

authors： Stephens L,Ellson C,Hawkins P

更新日期：2002-04-01 00:00:00

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:Cellular asymmetries have been proposed to play a role in plant embryogenesis. Genetic studies of Arabidopsis and other experimental approaches in several plant species have addressed the origins of cellular asymmetry in specific cases. Although zygote polarity, which precedes the formation of the apical-basal axis of...

journal_title：Current opinion in cell biology

authors： Jürgens G,Grebe M,Steinmann T

更新日期：1997-12-01 00:00:00

abstract：:Cellular plasticity is now recognized as a fundamental feature of tissue biology. The steady-state differentiation of stem and progenitor cells into mature cells is, in itself, the index form of cellular plasticity in adult organisms. Following injury, when it is critical to quickly regenerate and restore tissue integ...

journal_title：Current opinion in cell biology

authors： Paksa A,Rajagopal J

更新日期：2017-12-01 00:00:00

abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...

journal_title：Current opinion in cell biology

authors： Impens F,Vandekerckhove J,Gevaert K

更新日期：2010-12-01 00:00:00

abstract：:Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telome...

journal_title：Current opinion in cell biology

authors： Price CM

更新日期：1992-06-01 00:00:00

abstract：:Two key processes are in the basis of morphogenesis: the spatial allocation of cell types in fields of naïve cells and the regulation of growth. Both are controlled by morphogens, which activate target genes in the growing tissue in a concentration-dependent manner. Thus the morphogen model is an intrinsically quantit...

journal_title：Current opinion in cell biology

authors： Kicheva A,González-Gaitán M

更新日期：2008-04-01 00:00:00

abstract：:There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore t...

journal_title：Current opinion in cell biology

authors： Lee IH,Finkel T

更新日期：2013-12-01 00:00:00