Spatial encoding of GPCR signaling in the nervous system.

abstract：:Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli. The bacterium Escherichia coli performs chemotaxis via a run-and-tumble strategy in which sensitive temporal comparisons lead to a biased random walk, with longer runs in the preferred gradient direction. The chemotaxis networ...

journal_title：Current opinion in cell biology

authors： Sourjik V,Wingreen NS

更新日期：2012-04-01 00:00:00

abstract：:Recent advances in several key areas of fibronectin biology are discussed. These include its expression, from transcription to secretion of dimers, the structural requirements for several of the binding activities, potential roles for alternatively spliced segments in cell adhesion, and the assembly of a fibronectin m...

journal_title：Current opinion in cell biology

authors： Schwarzbauer JE

更新日期：1991-10-01 00:00:00

abstract：:The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...

journal_title：Current opinion in cell biology

authors： Nebreda AR,Ferby I

更新日期：2000-12-01 00:00:00

abstract：:The development of a complex multicellular organism requires a coordination of growth and cell division under the control of patterning mechanisms. Studies in yeast have pioneered our understanding of the relationship between growth and cell division. In recent years, many of the pathways that regulate growth in multi...

journal_title：Current opinion in cell biology

authors： Tapon N,Moberg KH,Hariharan IK

更新日期：2001-12-01 00:00:00

abstract：:The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, s...

journal_title：Current opinion in cell biology

authors： Hood JK,Silver PA

更新日期：1999-04-01 00:00:00

abstract：:A consensus view on the three-dimensional structure of the F-actin filament and the relative strength of the intersubunit contacts in the filament has been established from an atomic filament model and recent three-dimensional reconstructions from electron micrographs of F-actin filaments. Functional implications of r...

journal_title：Current opinion in cell biology

authors： Bremer A,Aebi U

更新日期：1992-02-01 00:00:00

abstract：:This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and ...

journal_title：Current opinion in cell biology

authors： DePamphilis ML

更新日期：1993-06-01 00:00:00

abstract：:Recent advances in our understanding of transcription factors that regulate RNA polymerase II transcribed genes are described. This review considers the role of alternate protein-protein interactions to yield positive or negative regulation, the consequences of deregulated factor activity on cell function and approach...

journal_title：Current opinion in cell biology

authors： Morimoto RI

更新日期：1992-06-01 00:00:00

abstract：:HOM/Hox genes are master regulatory switches that specify axial identity and control the growth and differentiation of groups of cells related by position. HOM/Hox genes function combinatorially and hierarchically to specify cell fate. Some of the genes they regulate and that mediate specific identify functions have b...

journal_title：Current opinion in cell biology

authors： Botas J

更新日期：1993-12-01 00:00:00

abstract：:The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings...

journal_title：Current opinion in cell biology

authors： Phua SC,Nihongaki Y,Inoue T

更新日期：2018-02-01 00:00:00

abstract：:Polarity is defined by the segregation of cellular components along a defined axis. To polarize robustly, cells must be able to break symmetry and subsequently amplify these nascent asymmetries. Finally, asymmetric localization of signaling molecules must be translated into functional regulation of downstream effector...

journal_title：Current opinion in cell biology

authors： Peglion F,Goehring NW

更新日期：2019-10-01 00:00:00

abstract：:The proposition is forwarded that the cAMP-dependent protein kinase is one of quite a small class of enzymes wherein differential modes of binding of its multiple substrates make an important contribution to the end physiological response. It is postulated that a variety of different substrate affinities may have evol...

journal_title：Current opinion in cell biology

authors： Walsh DA,Glass DB,Mitchell RD

更新日期：1992-04-01 00:00:00

abstract：:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...

journal_title：Current opinion in cell biology

authors： Falnes PO,Sandvig K

更新日期：2000-08-01 00:00:00

abstract：:Two key processes are in the basis of morphogenesis: the spatial allocation of cell types in fields of naïve cells and the regulation of growth. Both are controlled by morphogens, which activate target genes in the growing tissue in a concentration-dependent manner. Thus the morphogen model is an intrinsically quantit...

journal_title：Current opinion in cell biology

authors： Kicheva A,González-Gaitán M

更新日期：2008-04-01 00:00:00

abstract：:Several lines of evidence indicate that the lipids in the plasma membrane of animal cells are inhomogeneously distributed, and that various types of specialized lipid domains play an important role in many biological processes. The characteristics of these domains, such as size, composition and dynamics, are currently...

journal_title：Current opinion in cell biology

authors： Maxfield FR

更新日期：2002-08-01 00:00:00

abstract：:The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete in...

journal_title：Current opinion in cell biology

authors： Grünwald D,Singer RH

更新日期：2012-02-01 00:00:00

abstract：:Actin filaments, microtubules, and intermediate filaments, have all been found to be dynamic structures in living cells. Recent studies have shed important light on the assembly, disassembly, and mobility of these structures. In addition, a growing emphasis has been placed on the regulation of cytoskeletal activities ...

journal_title：Current opinion in cell biology

authors： Wang YL

更新日期：1991-02-01 00:00:00

abstract：:Dystroglycan provides a crucial linkage between the cytoskeleton and the basement membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of muscular dystrophy. Significant recent advances in understanding the structure and function of dystroglycan include detailed in vitro and in vivo an...

journal_title：Current opinion in cell biology

authors： Henry MD,Campbell KP

更新日期：1996-10-01 00:00:00

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal...

journal_title：Current opinion in cell biology

authors： Joshi CV,Enver T

更新日期：2002-12-01 00:00:00

abstract：:Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades. ...

journal_title：Current opinion in cell biology

authors： Anderson JM,Balda MS,Fanning AS

更新日期：1993-10-01 00:00:00

abstract：:Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of p...

journal_title：Current opinion in cell biology

authors： Rolland SG,Conradt B

更新日期：2010-12-01 00:00:00

abstract：:Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...

journal_title：Current opinion in cell biology

authors： Will CL,Lührmann R

更新日期：1997-06-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:Several recent scientific and technical developments have made it possible to postulate the use of the 'magic bullet' concept; that is, the identification of specific antigens present on tumor cells that can be targeted either by therapeutic antibodies or by small molecules. The use of monoclonal antibodies in cancer,...

journal_title：Current opinion in cell biology

authors： Houshmand P,Zlotnik A

更新日期：2003-10-01 00:00:00

abstract：:Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on the surrounding environment (i.e. cations etc.): from an extended 10-nm fiber, to a folded 30-nm fib...

journal_title：Current opinion in cell biology

authors： Maeshima K,Tamura S,Hansen JC,Itoh Y

更新日期：2020-06-01 00:00:00

abstract：:Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there ...

journal_title：Current opinion in cell biology

authors： Huber F,Boire A,López MP,Koenderink GH

更新日期：2015-02-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and produce one differentiating daughter cell. One of the most prominent...

journal_title：Current opinion in cell biology

authors： Loyer N,Januschke J

更新日期：2020-02-01 00:00:00

abstract：:Protection from cancer and ensured longevity are tightly linked in mammals. One of the fundamental mechanisms contributing to both is the cellular response to DNA damage. The appropriate response is an initial attempt at repair, but if the damage is too extensive or compromises DNA metabolism, a signalling cascade tri...

journal_title：Current opinion in cell biology

authors： Mitchell JR,Hoeijmakers JH,Niedernhofer LJ

更新日期：2003-04-01 00:00:00