Abstract：
:It is widely acknowledged that integrins, the major receptors for the extracellular matrix (ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors. Among them, growth factor receptors, such as the EGFR, MET, PDGFR and VEGFR, and the IL-3 receptor have been shown to be physically and functionally associated to integrins. The connection between integrins and other transmembrane receptors is bidirectional, integrins being essential for receptor signalling, and receptors being involved in regulation of integrin expression or activation. Moreover, there is accumulating evidence for direct binding of specific growth factors and morphogens to the ECM proteins, suggesting that ECM might spatially integrate different types of signals in a specific microenvironment, facilitating integrin/transmembrane receptors connection. These interactions are crucial in controlling a variety of cell behaviours including proliferation, survival and differentiation. The increasing interest for cell therapy in regenerative medicine has recently emphasized the role of cell-ECM adhesion as stem cell determinant. The relevance of ECM, integrins and growth factor receptor network in the establishment of stem cell niche, in maintenance of stem cells and in their differentiation will be analyzed in the present review.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Brizzi MF,Tarone G,Defilippi Pdoi
10.1016/j.ceb.2012.07.001subject
Has Abstractpub_date
2012-10-01 00:00:00pages
645-51issue
5eissn
0955-0674issn
1879-0410pii
S0955-0674(12)00102-0journal_volume
24pub_type
杂志文章,评审abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(92)90077-p
更新日期：1992-08-01 00:00:00
abstract：:Recent advances in understanding spatial genome organization inside the nucleus have shown that chromatin is compartmentalized into megabase-scale units known as topologically associating domains (TADs). In further studies, TADs were linked to differing transcriptional activity, suggesting that they might provide a sc...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.01.003
更新日期：2020-06-01 00:00:00
abstract：:Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic c...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.02.002
更新日期：2017-08-01 00:00:00
abstract：:Vesicle and tubule transport containers move proteins and lipids from one membrane system to another. Newly forming transport containers frequently have electron-dense coats. Coats coordinate the accumulation of cargo and sculpt the membrane. Recent advances have shown that components of both COP1 and clathrin-adaptor...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.06.009
更新日期：2004-08-01 00:00:00
abstract：:Inter-organelle membrane contact sites are zones where heterologous membranes, usually the endoplasmic reticulum plus a partner organelle, come into close apposition. These sites are very poorly understood because so few of their components have been identified; however, it is clear that they are specialised for traff...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2006.06.011
更新日期：2006-08-01 00:00:00
abstract：:Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on the surrounding environment (i.e. cations etc.): from an extended 10-nm fiber, to a folded 30-nm fib...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.02.016
更新日期：2020-06-01 00:00:00
abstract：:The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.04.001
更新日期：2013-10-01 00:00:00
abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00142-3
更新日期：2000-10-01 00:00:00
abstract：:There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while exclud...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(97)80030-0
更新日期：1997-08-01 00:00:00
abstract：:Diverse post-translational modifications of histone amino termini represent an important epigenetic mechanism for the organisation of chromatin structure and the regulation of gene activity. Within the past two years, great progress has been made in understanding the functional implications of histone methylation; in ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00335-6
更新日期：2002-06-01 00:00:00
abstract：:Several aspects of the interactions between growth factors and cell adhesion are described. Recent advances in the field come from the identification of molecules resembling growth factors or growth factor receptors, which bear cell adhesion motifs as well as molecules participating in both cell growth control and adh...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(92)90101-h
更新日期：1992-10-01 00:00:00
abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(95)80017-4
更新日期：1995-08-01 00:00:00
abstract：:Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a static regular structure to a dynamic and highly variable configuration. While the details are not fully understood yet, chromatin ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.02.003
更新日期：2019-06-01 00:00:00
abstract：:Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2018.12.006
更新日期：2019-04-01 00:00:00
abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.04.001
更新日期：2016-10-01 00:00:00
abstract：:A hallmark of polarity in most migrating cells is the orientation of the nuclear centrosomal (NC) axis relative to the front-back cellular axis. Here, we review 'effector functions' associated with the NC axis during cell migration. We highlight recent research that has demonstrated that the orientation of the NC axis...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.08.001
更新日期：2011-10-01 00:00:00
abstract：:Cell migration is a universal process involving different morphologies and mechanisms in different cell types and tissue environments. Prespecified cell-type-specific patterns of cell migration can be classified into single cell migration (amoeboid, mesenchymal) and collective migration modes (cell sheets, strands, tu...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2003.11.001
更新日期：2004-02-01 00:00:00
abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2018.01.005
更新日期：2018-06-01 00:00:00
abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2015.01.004
更新日期：2015-02-01 00:00:00
abstract：:Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00111-3
更新日期：2000-08-01 00:00:00
abstract：:The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.07.012
更新日期：2019-12-01 00:00:00
abstract：:Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing nu...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(93)90018-l
更新日期：1993-06-01 00:00:00
abstract：:The cortical force-generating machinery pulls on dynamic plus-ends of astral microtubules to control spindle position and orientation, which underlie division type specification and cellular patterning in many eukaryotic cells. A prior work identified cytoplasmic dynein, a minus-end directed microtubule motor, as a ke...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.03.001
更新日期：2019-10-01 00:00:00
abstract：:Cell-cell signalling is an essential process in the formation of multicellular organisms. Notch is the receptor of an evolutionarily conserved signalling pathway regulating numerous developmental decisions. Indeed, its misregulation is linked to multiple developmental and physiological disorders. Notch and its ligands...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2006.02.011
更新日期：2006-04-01 00:00:00
abstract：:One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent in...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.11.004
更新日期：2006-02-01 00:00:00
abstract：:Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, pha...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00311-3
更新日期：2002-04-01 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.02.002
更新日期：2005-04-01 00:00:00
abstract：:The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)protein...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(95)80107-3
更新日期：1995-10-01 00:00:00
abstract：:How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.10.001
更新日期：2012-12-01 00:00:00
abstract：:Analysis of complex and redundant pathways that control proliferation, differentiation, apoptosis and DNA damage response by global genome wide analysis is an intensive area of investigation aimed at identifying unique molecular signatures of prognostic significance in cancer. An alternative approach is to focus on th...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2007.10.005
更新日期：2007-12-01 00:00:00
