Abstract：
:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Brown NHdoi
10.1016/s0955-0674(00)00142-3subject
Has Abstractpub_date
2000-10-01 00:00:00pages
629-33issue
5eissn
0955-0674issn
1879-0410pii
S0955-0674(00)00142-3journal_volume
12pub_type
杂志文章,评审abstract：:Cyclin-dependent kinase (CDK) 7 was originally implicated in cell cycle control by virtue of its ability to phosphorylate and activate other CDKs. Subsequently, both CDK7 and its partner, cyclin H, were found to be associated with the general transcription factor TFIIH, suggesting additional roles for CDK7 in transcri...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(96)80003-2
更新日期：1996-06-01 00:00:00
abstract：:There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore t...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.07.002
更新日期：2013-12-01 00:00:00
abstract：:Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing nu...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(93)90018-l
更新日期：1993-06-01 00:00:00
abstract：:At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'singl...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.04.008
更新日期：2020-10-01 00:00:00
abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.04.001
更新日期：2016-10-01 00:00:00
abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/S0955-0674(99)80050-7
更新日期：1999-06-01 00:00:00
abstract：:Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term change...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.01.004
更新日期：2012-04-01 00:00:00
abstract：:The rate at which receptors have been cloned has recently increased dramatically--existing families have been extended and new families created. The rapid cloning by homology of 'orphan receptors' has also stimulated the development of a new reverse pharmacology. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(91)90142-l
更新日期：1991-04-01 00:00:00
abstract：:The G protein-coupled receptor (GPCR) family is among the most druggable families in the human proteome. GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology. The means by which the activity of GPCRs can be modulated have been expanded by e...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.11.006
更新日期：2014-04-01 00:00:00
abstract：:Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a static regular structure to a dynamic and highly variable configuration. While the details are not fully understood yet, chromatin ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.02.003
更新日期：2019-06-01 00:00:00
abstract：:The Drosophila decapentaplegic gene, the Xenopus activin genes and the genes encoding the mouse bone morphogenetic proteins are transforming growth factor-beta-related genes whose roles in development are the focus of current studies. They exhibit elaborate patterns of expression during development, and the protein pr...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(91)90112-c
更新日期：1991-12-01 00:00:00
abstract：:Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of p...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.07.014
更新日期：2010-12-01 00:00:00
abstract：:The establishment of left-right asymmetry during development of vertebrate embryos depends on leftward flow in the nodal cavity. The flow is produced by the rotational movement of the posteriorly tilted nodal cilia. However, it remains poorly understood how the nodal cilia are tilted posteriorly, and how the direction...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.01.002
更新日期：2012-02-01 00:00:00
abstract：:How linear DNA molecules are packaged into compact cylindrical chromosomes in preparation for cell division has remained one of the central outstanding questions in cell biology. Condensin is a highly conserved protein complex that universally determines large-scale DNA geometry during mitotic chromosome assembly. A w...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.03.005
更新日期：2019-10-01 00:00:00
abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(03)00070-x
更新日期：2003-08-01 00:00:00
abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(96)80108-6
更新日期：1996-10-01 00:00:00
abstract：:Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emer...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.12.007
更新日期：2021-01-12 00:00:00
abstract：:The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete in...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.11.011
更新日期：2012-02-01 00:00:00
abstract：:Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00170-8
更新日期：2001-02-01 00:00:00
abstract：:The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while exclud...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(97)80030-0
更新日期：1997-08-01 00:00:00
abstract：:For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosom...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00328-9
更新日期：2002-06-01 00:00:00
abstract：:Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cov...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2018.06.010
更新日期：2018-12-01 00:00:00
abstract：:Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli. The bacterium Escherichia coli performs chemotaxis via a run-and-tumble strategy in which sensitive temporal comparisons lead to a biased random walk, with longer runs in the preferred gradient direction. The chemotaxis networ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.11.008
更新日期：2012-04-01 00:00:00
abstract：:The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by o...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.06.008
更新日期：2005-08-01 00:00:00
abstract：:The long-standing interest in centrioles and basal bodies stems from the evolutionary conservation of their structural design and from their dual mode of assembly (templated versus de novo), revealed by electron microscopic studies nearly four decades ago and unique for a subcellular organelle. Molecular dissection of...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00017-0
更新日期：2003-02-01 00:00:00
abstract：:This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(93)90008-e
更新日期：1993-06-01 00:00:00
abstract：:There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the prox...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.05.003
更新日期：2010-08-01 00:00:00
abstract：:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00109-5
更新日期：2000-08-01 00:00:00
abstract：:In Caenorhabditis elegans, cell migration is guided by localized cues, including molecules such as EGL-17/FGF and UNC-6/netrin. These external cues are linked to an intracellular response to migrate, at least in part, by CED-5, a homolog of DOCK180/MBC, and MIG-2, a Rac-like GTPase. In addition, metalloproteases are r...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(99)00028-9
更新日期：1999-10-01 00:00:00
