Mechanisms of motor protein reversal.

abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...

journal_title：Current opinion in cell biology

authors： Janicki SM,Spector DL

更新日期：2003-04-01 00:00:00

abstract：:Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center and rear. In this review, we will present our understanding of the regulation of adhesion turnover and disassembly in various regions of the cell. Adhesion turnover involves a number of tyrosine kinas...

journal_title：Current opinion in cell biology

authors： Broussard JA,Webb DJ,Kaverina I

更新日期：2008-02-01 00:00:00

abstract：:Protection from cancer and ensured longevity are tightly linked in mammals. One of the fundamental mechanisms contributing to both is the cellular response to DNA damage. The appropriate response is an initial attempt at repair, but if the damage is too extensive or compromises DNA metabolism, a signalling cascade tri...

journal_title：Current opinion in cell biology

authors： Mitchell JR,Hoeijmakers JH,Niedernhofer LJ

更新日期：2003-04-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:Microtubules are polymeric tubes that switch between phases of growth and shortening, and this property is essential to drive key cellular processes. Microtubules are composed of protofilaments formed by longitudinally arranged tubulin dimers. Microtubule dynamics can be affected by structural perturbations at the plu...

journal_title：Current opinion in cell biology

authors： Aher A,Akhmanova A

更新日期：2018-02-01 00:00:00

abstract：:The basic mechanisms of serine/threonine protein kinase signaling networks have been elucidated in the past decade. Members of the protein kinase C (PKC) family are crucial in T cell signaling pathways. Particularly, PKC alpha, PKC beta, and PKC theta isotypes determine the nature of lymphocyte-specific in vivo effect...

journal_title：Current opinion in cell biology

authors： Baier G,Wagner J

更新日期：2009-04-01 00:00:00

abstract：:Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression. ...

journal_title：Current opinion in cell biology

authors： Nigg EA

更新日期：1993-04-01 00:00:00

abstract：:Particle engulfment during phagocytosis has long been appreciated to be an active, actin-driven process. By contrast, the preceding stage--securing the target to the surface of the phagocyte--was thought to result from the passive diffusion of receptors along the membrane towards their ligands on the particle surface....

journal_title：Current opinion in cell biology

authors： Jaumouillé V,Grinstein S

更新日期：2011-02-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...

journal_title：Current opinion in cell biology

authors： Tapon N,Hall A

更新日期：1997-02-01 00:00:00

abstract：:Several lines of evidence indicate that the lipids in the plasma membrane of animal cells are inhomogeneously distributed, and that various types of specialized lipid domains play an important role in many biological processes. The characteristics of these domains, such as size, composition and dynamics, are currently...

journal_title：Current opinion in cell biology

authors： Maxfield FR

更新日期：2002-08-01 00:00:00

abstract：:The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...

journal_title：Current opinion in cell biology

authors： Ringrose L

更新日期：2007-06-01 00:00:00

abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...

journal_title：Current opinion in cell biology

authors： Capetanaki Y,Papathanasiou S,Diokmetzidou A,Vatsellas G,Tsikitis M

更新日期：2015-02-01 00:00:00

abstract：:Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic c...

journal_title：Current opinion in cell biology

authors： Barneda D,Christian M

更新日期：2017-08-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic outputs. While some secretory cell types have a remarkable ability to increase protein folding capacity, their upper limits can be reached ...

journal_title：Current opinion in cell biology

authors： Shore GC,Papa FR,Oakes SA

更新日期：2011-04-01 00:00:00

abstract：:The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokine...

journal_title：Current opinion in cell biology

authors： Agace WW,Higgins JM,Sadasivan B,Brenner MB,Parker CM

更新日期：2000-10-01 00:00:00

abstract：:Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCF(Fbxw7) ubiquitin ligase, which is frequen...

journal_title：Current opinion in cell biology

authors： Kourtis N,Strikoudis A,Aifantis I

更新日期：2015-12-01 00:00:00

abstract：:Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, pha...

journal_title：Current opinion in cell biology

authors： Stephens L,Ellson C,Hawkins P

更新日期：2002-04-01 00:00:00

abstract：:Senescence represents a permanent exit from the cell cycle and its role in curtailing the proliferation of damaged and potentially oncogenic cells has relevance both as a front-line defense against cancer and as an underlying cause of aging. The retinoblastoma protein (RB) and p53 tumor suppressors are central to the ...

journal_title：Current opinion in cell biology

authors： Chandler H,Peters G

更新日期：2013-12-01 00:00:00

abstract：:Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....

journal_title：Current opinion in cell biology

authors： Kang YK,Lee KK,Han YM

更新日期：2003-06-01 00:00:00

abstract：:Plant cells are connected across cell walls by nanoscopic channels called plasmodesmata (PD), which allow plant cells to share resources and exchange signaling molecules. Several protein components of PD membranes have been identified, and recent advances in superresolution live-cell microscopy are illuminating PD ult...

journal_title：Current opinion in cell biology

authors： Brunkard JO,Runkel AM,Zambryski PC

更新日期：2015-08-01 00:00:00

abstract：:Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, sig...

journal_title：Current opinion in cell biology

authors： Bertuch AA,Lundblad V

更新日期：2006-06-01 00:00:00

abstract：:Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cov...

journal_title：Current opinion in cell biology

authors： Bigas A,Espinosa L

更新日期：2018-12-01 00:00:00

abstract：:Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...

journal_title：Current opinion in cell biology

authors： Weinberg ZY,Crilly SE,Puthenveedu MA

更新日期：2019-04-01 00:00:00

abstract：:Centrioles are essential microtubule-based organelles, typically present in pairs, which organize cilia and centrosomes. Their mode of biogenesis is unique for a subcellular organelle since, during cell division, each pre-existing centriole guides the formation of a new one, a process that is coordinated with DNA repl...

journal_title：Current opinion in cell biology

authors： Meunier A,Spassky N

更新日期：2016-02-01 00:00:00

abstract：:Hermansky-Pudlak syndrome defines a group of genetic disorders characterized by defects in organelles of the endosomal-lysosomal system, most notably melanosomes and platelet-dense granules. About a dozen genes have been implicated in the pathogenesis of the disease in humans and mice. Most of these genes encode novel...

journal_title：Current opinion in cell biology

authors： Dell'Angelica EC

更新日期：2004-08-01 00:00:00

abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...

journal_title：Current opinion in cell biology

authors： Brown NH

更新日期：2000-10-01 00:00:00

abstract：:Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly ...

journal_title：Current opinion in cell biology

authors： Cramer LP,Mitchison TJ,Theriot JA

更新日期：1994-02-01 00:00:00

abstract：:Diverse post-translational modifications of histone amino termini represent an important epigenetic mechanism for the organisation of chromatin structure and the regulation of gene activity. Within the past two years, great progress has been made in understanding the functional implications of histone methylation; in ...

journal_title：Current opinion in cell biology

authors： Lachner M,Jenuwein T

更新日期：2002-06-01 00:00:00