Abstract：
:Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emerged as an important mechanism for regulating protein phase separation propensities and localization patterns into different condensates, affecting compositions and dynamics. Key factors in transcription, mRNA processing and translation exhibit such phosphorylation-dependent changes in their roles within condensates, including their catalytic activities. Phosphorylation is increasingly understood to regulate the exchange of proteins through functionally linked condensates to fulfil their mRNA metabolic functions.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Nosella ML,Forman-Kay JDdoi
10.1016/j.ceb.2020.12.007subject
Has Abstractpub_date
2021-01-12 00:00:00pages
30-40eissn
0955-0674issn
1879-0410pii
S0955-0674(20)30172-1journal_volume
69pub_type
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journal_title：Current opinion in cell biology
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