HIF-1 and mechanisms of hypoxia sensing.

abstract：:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on i...

journal_title：Current opinion in cell biology

authors： Imamoto N,Funakoshi T

更新日期：2012-08-01 00:00:00

abstract：:Recent discoveries have converged on the emerging enzymology that governs the G1-S phase transition of the mammalian somatic cell cycle. These discoveries have led to an appreciation of the regulatory role of proline-directed protein phosphorylation in molecular signalling, and have resulted in the identification of a...

journal_title：Current opinion in cell biology

authors： Hall FL,Vulliet PR

更新日期：1991-04-01 00:00:00

abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...

journal_title：Current opinion in cell biology

authors： Surani MA

更新日期：1994-06-01 00:00:00

abstract：:The study of eukaryotic telomeres at the molecular level began with the discovery of short, tandem repeats at Tetrahymena chromosome ends. In the following two decades, major insights about telomere structure and function have come from investigations of telomerase, the DNA polymerase that synthesizes these repeats. I...

journal_title：Current opinion in cell biology

authors： Collins K

更新日期：1996-06-01 00:00:00

abstract：:Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, sig...

journal_title：Current opinion in cell biology

authors： Bertuch AA,Lundblad V

更新日期：2006-06-01 00:00:00

abstract：:The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)protein...

journal_title：Current opinion in cell biology

authors： Wassarman PM

更新日期：1995-10-01 00:00:00

abstract：:Several recently discovered mammalian cell adhesion proteins recognize and bind to sialic acid-containing ligands. Reports concerning the molecular specificities of these interactions have been intriguing but somewhat confusing, partly because of pitfalls in methodology or interpretation. Nevertheless, these protein-c...

journal_title：Current opinion in cell biology

authors： Varki A

更新日期：1992-04-01 00:00:00

abstract：:Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Cur...

journal_title：Current opinion in cell biology

authors： Schwartz YB,Pirrotta V

更新日期：2008-06-01 00:00:00

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

journal_title：Current opinion in cell biology

authors： Hoenger A,McIntosh JR

更新日期：2009-02-01 00:00:00

abstract：:A standout feature of eukaryotic cells is the presence of organelles with distinct chemical compositions and physical properties, which aid in the accomplishment of specialized metabolic tasks. This complex topology, however, makes a permanent crosstalk between the organelles a necessity for the coordination of cellul...

journal_title：Current opinion in cell biology

authors： Lang A,John Peter AT,Kornmann B

更新日期：2015-08-01 00:00:00

abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...

journal_title：Current opinion in cell biology

authors： Janicki SM,Spector DL

更新日期：2003-04-01 00:00:00

abstract：:The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-...

journal_title：Current opinion in cell biology

authors： Scheibner K,Bakhti M,Bastidas-Ponce A,Lickert H

更新日期：2019-12-01 00:00:00

abstract：:Protection from cancer and ensured longevity are tightly linked in mammals. One of the fundamental mechanisms contributing to both is the cellular response to DNA damage. The appropriate response is an initial attempt at repair, but if the damage is too extensive or compromises DNA metabolism, a signalling cascade tri...

journal_title：Current opinion in cell biology

authors： Mitchell JR,Hoeijmakers JH,Niedernhofer LJ

更新日期：2003-04-01 00:00:00

abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...

journal_title：Current opinion in cell biology

authors： Brown NH

更新日期：2000-10-01 00:00:00

abstract：:As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...

journal_title：Current opinion in cell biology

authors： Zen K,Parkos CA

更新日期：2003-10-01 00:00:00

abstract：:Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, pha...

journal_title：Current opinion in cell biology

authors： Stephens L,Ellson C,Hawkins P

更新日期：2002-04-01 00:00:00

abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

journal_title：Current opinion in cell biology

authors： Ploubidou A,Way M

更新日期：2001-02-01 00:00:00

abstract：:One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent in...

journal_title：Current opinion in cell biology

authors： Bond J,Woods CG

更新日期：2006-02-01 00:00:00

abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...

journal_title：Current opinion in cell biology

authors： Burke B

更新日期：2018-06-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:As in yeast and mammalian cells, novel unconventional protein secretion (UPS) or unconventional membrane trafficking pathways are now known to operate in plants. UPS in plants is generally associated with stress conditions such as pathogen attack, but little is known about its underlying mechanism and function. Here, ...

journal_title：Current opinion in cell biology

authors： Ding Y,Robinson DG,Jiang L

更新日期：2014-08-01 00:00:00

abstract：:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors i...

journal_title：Current opinion in cell biology

authors： Hakes AE,Brand AH

更新日期：2019-10-01 00:00:00

abstract：:Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship betw...

journal_title：Current opinion in cell biology

authors： Weber SC

更新日期：2017-06-01 00:00:00

abstract：:Plant cells are connected across cell walls by nanoscopic channels called plasmodesmata (PD), which allow plant cells to share resources and exchange signaling molecules. Several protein components of PD membranes have been identified, and recent advances in superresolution live-cell microscopy are illuminating PD ult...

journal_title：Current opinion in cell biology

authors： Brunkard JO,Runkel AM,Zambryski PC

更新日期：2015-08-01 00:00:00

abstract：:The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and...

journal_title：Current opinion in cell biology

authors： Ahn NG,Seger R,Krebs EG

更新日期：1992-12-01 00:00:00

abstract：:The past several years have seen major advances in our understanding of the mechanisms of microtubule destabilization by oncoprotein18/stathmin (Op18/stathmin) and related proteins. New structural information has clearly shown how members of the Op18/stathmin protein family bind tubulin dimers and suggests models for ...

journal_title：Current opinion in cell biology

authors： Cassimeris L

更新日期：2002-02-01 00:00:00

abstract：:Organelles of the central membrane system of higher eukaryotes have been shown to utilize microtubules both for maintenance of their characteristic spatial distributions and for efficient transport of their protein and lipid to diverse sites within the cell. Recent work addressing the mechanisms that underlie this org...

journal_title：Current opinion in cell biology

authors： Cole NB,Lippincott-Schwartz J

更新日期：1995-02-01 00:00:00

abstract：:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...

journal_title：Current opinion in cell biology

authors： Schweizer N,Weiss M,Maiato H

更新日期：2014-06-01 00:00:00

abstract：:Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis fo...

journal_title：Current opinion in cell biology

authors： Griffith JK,Baker ME,Rouch DA,Page MG,Skurray RA,Paulsen IT,Chater KF,Baldwin SA,Henderson PJ

更新日期：1992-08-01 00:00:00