The mitogen-activated protein kinase activator.

abstract：:Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial ...

journal_title：Current opinion in cell biology

authors： Franz A,Kevei É,Hoppe T

更新日期：2015-12-01 00:00:00

abstract：:While canonical 3'end modifications of mRNAs or tRNAs are well established, recent technological advances in RNA analysis have given us a glimpse of how widespread other types of distinctive 3'end modifications appear to be. Next to alternative nuclear or cytoplasmic polyadenylation mechanisms, evidence accumulated fo...

journal_title：Current opinion in cell biology

authors： Minasaki R,Eckmann CR

更新日期：2012-06-01 00:00:00

abstract：:Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades. ...

journal_title：Current opinion in cell biology

authors： Anderson JM,Balda MS,Fanning AS

更新日期：1993-10-01 00:00:00

abstract：:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...

journal_title：Current opinion in cell biology

authors： Schweizer N,Weiss M,Maiato H

更新日期：2014-06-01 00:00:00

abstract：:How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...

journal_title：Current opinion in cell biology

authors： Hachet O,Bendezú FO,Martin SG

更新日期：2012-12-01 00:00:00

abstract：:The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport...

journal_title：Current opinion in cell biology

authors： Mandon EC,Trueman SF,Gilmore R

更新日期：2009-08-01 00:00:00

abstract：:There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the prox...

journal_title：Current opinion in cell biology

authors： Nakano A,Luini A

更新日期：2010-08-01 00:00:00

abstract：:Far from being simple 'bags' of enzymes, bacteria are richly endowed with ultrastructures that challenge and expand standard definitions of the cytoskeleton. Here we review rods, rings, twisted pairs, tubes, sheets, spirals, moving patches, meshes and composites, and suggest defining the term 'bacterial cytoskeleton' ...

journal_title：Current opinion in cell biology

authors： Pilhofer M,Jensen GJ

更新日期：2013-02-01 00:00:00

abstract：:The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, s...

journal_title：Current opinion in cell biology

authors： Hood JK,Silver PA

更新日期：1999-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...

journal_title：Current opinion in cell biology

authors： Gelman L,Michalik L,Desvergne B,Wahli W

更新日期：2005-04-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:New structural analyses of the spectrin family of actin cross-linking proteins are providing molecular explanations for both the interchain binding between the alpha and beta chains of spectrin and the intermolecular associations between spectrin and other proteins. Additionally, the analyses bring into focus a confor...

journal_title：Current opinion in cell biology

authors： Viel A,Branton D

更新日期：1996-02-01 00:00:00

abstract：:Considerable advances into the basis of RNA-polymerase-II-mediated transcriptional regulation have recently emerged. Biochemical, genetic and structural studies have contributed to novel insights into transcription, as well as the functional significance of covalent histone modifications. New details regarding transcr...

journal_title：Current opinion in cell biology

authors： Sims RJ 3rd,Mandal SS,Reinberg D

更新日期：2004-06-01 00:00:00

abstract：:Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCF(Fbxw7) ubiquitin ligase, which is frequen...

journal_title：Current opinion in cell biology

authors： Kourtis N,Strikoudis A,Aifantis I

更新日期：2015-12-01 00:00:00

abstract：:Transcriptional coactivators enhance gene expression by associating with sequence-specific transcription factors and serve as the primary targets of developmental and physiological signals in diverse biological processes. Recent studies have revealed key roles for transcriptional coactivators in the control of gene ex...

journal_title：Current opinion in cell biology

authors： Liu N,Olson EN

更新日期：2006-12-01 00:00:00

abstract：:The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings...

journal_title：Current opinion in cell biology

authors： Phua SC,Nihongaki Y,Inoue T

更新日期：2018-02-01 00:00:00

abstract：:Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded,...

journal_title：Current opinion in cell biology

authors： Dahlberg JE,Lund E

更新日期：2004-06-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...

journal_title：Current opinion in cell biology

authors： Falnes PO,Sandvig K

更新日期：2000-08-01 00:00:00

abstract：:In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to ge...

journal_title：Current opinion in cell biology

authors： Irvine RF

更新日期：1992-04-01 00:00:00

abstract：:Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...

journal_title：Current opinion in cell biology

authors： Davis S,Yancopoulos GD

更新日期：1993-04-01 00:00:00

abstract：:Recent advances in understanding spatial genome organization inside the nucleus have shown that chromatin is compartmentalized into megabase-scale units known as topologically associating domains (TADs). In further studies, TADs were linked to differing transcriptional activity, suggesting that they might provide a sc...

journal_title：Current opinion in cell biology

authors： Ibrahim DM,Mundlos S

更新日期：2020-06-01 00:00:00

abstract：:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on i...

journal_title：Current opinion in cell biology

authors： Imamoto N,Funakoshi T

更新日期：2012-08-01 00:00:00

abstract：:The field of molecular physiology of ClC chloride channels has witnessed a tremendous surge in knowledge over the past few years; however, fundamental issues such as the stoichiometry of ClC channels and the identification of pore-lining sequences have only recently begun to be addressed. New studies have also provide...

journal_title：Current opinion in cell biology

authors： Valverde MA

更新日期：1999-08-01 00:00:00

abstract：:The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the know...

journal_title：Current opinion in cell biology

authors： Weaver AM,Young ME,Lee WL,Cooper JA

更新日期：2003-02-01 00:00:00

abstract：:Within the class of integral membrane proteins, the bacterial porins display a remarkable resistance to denaturants and proteases. This stability is probably crucial for the formation of highly ordered, three-dimensional crystals. Structural analysis of these crystals has been possible in atomic detail. This analysis ...

journal_title：Current opinion in cell biology

authors： Schulz GE

更新日期：1993-08-01 00:00:00

abstract：:Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface adhesion receptors, such as the cadherins and integrins. Much attention has focused on identifying how these adhesion receptors transmit force. In contrast, less is known regarding how these force-activated pathways are int...

journal_title：Current opinion in cell biology

authors： Salvi AM,DeMali KA

更新日期：2018-10-01 00:00:00

abstract：:Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telome...

journal_title：Current opinion in cell biology

authors： Price CM

更新日期：1992-06-01 00:00:00

abstract：:Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli. The bacterium Escherichia coli performs chemotaxis via a run-and-tumble strategy in which sensitive temporal comparisons lead to a biased random walk, with longer runs in the preferred gradient direction. The chemotaxis networ...

journal_title：Current opinion in cell biology

authors： Sourjik V,Wingreen NS

更新日期：2012-04-01 00:00:00

abstract：:Research into the molecular mechanisms of target cell recognition by natural killer (NK) cells has recently progressed rapidly. NK cells express several MHC I recognizing receptors that inactivate the NK cells' functions. In pathological alterations of MHC I expression, the NK cell inhibitory receptors do not engage a...

journal_title：Current opinion in cell biology

authors： Timonen T,Helander TS

更新日期：1997-10-01 00:00:00