Abstract:
:The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the known activators. WASPs bind to Arp2/3 via an acidic (A) domain, and a WH2 domain appears to bring an actin monomer to Arp2/3, promoting the nucleation of the new filament. Cortactin also binds the Arp2/3 complex via an A domain; however, it also binds to actin filaments, which helps activate the Arp2/3 complex and stabilise the newly created branches between the filaments.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Weaver AM,Young ME,Lee WL,Cooper JAdoi
10.1016/s0955-0674(02)00015-7subject
Has Abstractpub_date
2003-02-01 00:00:00pages
23-30issue
1eissn
0955-0674issn
1879-0410pii
S0955067402000157journal_volume
15pub_type
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journal_title:Current opinion in cell biology
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