Extracellular matrix alters epithelial differentiation.

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

journal_title：Current opinion in cell biology

authors： Suganuma T,Workman JL

更新日期：2013-06-01 00:00:00

abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

journal_title：Current opinion in cell biology

authors： Gruenberg J,Clague MJ

更新日期：1992-08-01 00:00:00

abstract：:The G protein-coupled receptor (GPCR) family is among the most druggable families in the human proteome. GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology. The means by which the activity of GPCRs can be modulated have been expanded by e...

journal_title：Current opinion in cell biology

authors： Giguere PM,Kroeze WK,Roth BL

更新日期：2014-04-01 00:00:00

abstract：:Cell adhesion occurs via a highly regulated set of sequential interactions. Prototypic components of a variety of adhesion cascades are discussed, including integrins, triggering molecules and lectin-carbohydrate interactions. Selectivity and efficiency are achieved by utilizing the right combination of multiple adhes...

journal_title：Current opinion in cell biology

authors： Schweighoffer T,Shaw S

更新日期：1992-10-01 00:00:00

abstract：:A standout feature of eukaryotic cells is the presence of organelles with distinct chemical compositions and physical properties, which aid in the accomplishment of specialized metabolic tasks. This complex topology, however, makes a permanent crosstalk between the organelles a necessity for the coordination of cellul...

journal_title：Current opinion in cell biology

authors： Lang A,John Peter AT,Kornmann B

更新日期：2015-08-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:As the largest and stiffest organelle in the cell, the nucleus can be subjected to significant forces generated by the cytoskeleton to adjust its shape and position, and accommodate the cellular machinery during cell migration, differentiation or division. As it was anticipated, recent work showed that mechanosensitiv...

journal_title：Current opinion in cell biology

authors： Aureille J,Belaadi N,Guilluy C

更新日期：2017-02-01 00:00:00

abstract：:The arrangement and dynamics of chromosomes inside the nucleus of mammalian cells have been studied intensively over the last two years. Although chromosomes are relatively immobile and occupy non-random positions in interphase, their dynamic movements in mitosis have traditionally been assumed to randomize this arran...

journal_title：Current opinion in cell biology

authors： Gerlich D,Ellenberg J

更新日期：2003-12-01 00:00:00

abstract：:The basic mechanisms of serine/threonine protein kinase signaling networks have been elucidated in the past decade. Members of the protein kinase C (PKC) family are crucial in T cell signaling pathways. Particularly, PKC alpha, PKC beta, and PKC theta isotypes determine the nature of lymphocyte-specific in vivo effect...

journal_title：Current opinion in cell biology

authors： Baier G,Wagner J

更新日期：2009-04-01 00:00:00

abstract：:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...

journal_title：Current opinion in cell biology

authors： Schweizer N,Weiss M,Maiato H

更新日期：2014-06-01 00:00:00

abstract：:Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship betw...

journal_title：Current opinion in cell biology

authors： Weber SC

更新日期：2017-06-01 00:00:00

abstract：:Several aspects of the interactions between growth factors and cell adhesion are described. Recent advances in the field come from the identification of molecules resembling growth factors or growth factor receptors, which bear cell adhesion motifs as well as molecules participating in both cell growth control and adh...

journal_title：Current opinion in cell biology

authors： Thiery JP,Boyer B

更新日期：1992-10-01 00:00:00

abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...

journal_title：Current opinion in cell biology

authors： Doyle AD,Petrie RJ,Kutys ML,Yamada KM

更新日期：2013-10-01 00:00:00

abstract：:Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded,...

journal_title：Current opinion in cell biology

authors： Dahlberg JE,Lund E

更新日期：2004-06-01 00:00:00

abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...

journal_title：Current opinion in cell biology

authors： Surani MA

更新日期：1994-06-01 00:00:00

abstract：:Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...

journal_title：Current opinion in cell biology

authors： Davis S,Yancopoulos GD

更新日期：1993-04-01 00:00:00

abstract：:Autophagy is a crucial component of the cellular stress adaptation response that maintains mammalian homeostasis. Autophagy protects against neurodegenerative and inflammatory conditions, aging, and cancer. This is accomplished by the degradation and intracellular recycling of cellular components to maintain energy me...

journal_title：Current opinion in cell biology

authors： White E,Karp C,Strohecker AM,Guo Y,Mathew R

更新日期：2010-04-01 00:00:00

abstract：:The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities. This is achieved by modulating the dynamic properties of mit...

journal_title：Current opinion in cell biology

authors： Hoppins S

更新日期：2014-08-01 00:00:00

abstract：:Caveolae are essential endocytic organelles that use glycosyl-phosphatidyl-inositol (GPI)-anchored membrane proteins to concentrate low molecular weight substances before delivery to the cell. Caveolae and GPI-anchored proteins are uniquely adapted for this task. Recent advances suggest that this endocytic pathway als...

journal_title：Current opinion in cell biology

authors： Anderson RG

更新日期：1993-08-01 00:00:00

abstract：:Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have...

journal_title：Current opinion in cell biology

authors： Sternweis PC

更新日期：1994-04-01 00:00:00

abstract：:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical pro...

journal_title：Current opinion in cell biology

authors： Roll-Mecak A

更新日期：2019-02-01 00:00:00

abstract：:Inter-organelle membrane contact sites are zones where heterologous membranes, usually the endoplasmic reticulum plus a partner organelle, come into close apposition. These sites are very poorly understood because so few of their components have been identified; however, it is clear that they are specialised for traff...

journal_title：Current opinion in cell biology

authors： Levine T,Loewen C

更新日期：2006-08-01 00:00:00

abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...

journal_title：Current opinion in cell biology

authors： Tacke R,Manley JL

更新日期：1999-06-01 00:00:00

abstract：:Recent discoveries have converged on the emerging enzymology that governs the G1-S phase transition of the mammalian somatic cell cycle. These discoveries have led to an appreciation of the regulatory role of proline-directed protein phosphorylation in molecular signalling, and have resulted in the identification of a...

journal_title：Current opinion in cell biology

authors： Hall FL,Vulliet PR

更新日期：1991-04-01 00:00:00

abstract：:The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of ...

journal_title：Current opinion in cell biology

authors： McCawley LJ,Matrisian LM

更新日期：2001-10-01 00:00:00

abstract：:Primordial germ cells (PGCs), the progenitors of the gametes, migrate from the position where they are specified towards the region where the gonad develops. To reach their target, the PGCs obtain directional cues from cells positioned along their migration path. One such cue, the chemokine SDF-1, has recently been fo...

journal_title：Current opinion in cell biology

authors： Raz E

更新日期：2004-04-01 00:00:00

abstract：:The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-...

journal_title：Current opinion in cell biology

authors： Scheibner K,Bakhti M,Bastidas-Ponce A,Lickert H

更新日期：2019-12-01 00:00:00

abstract：:The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...

journal_title：Current opinion in cell biology

authors： Nebreda AR,Ferby I

更新日期：2000-12-01 00:00:00

abstract：:Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients pre...

journal_title：Current opinion in cell biology

authors： Majumdar R,Sixt M,Parent CA

更新日期：2014-10-01 00:00:00