Neurofilament assembly and function during neuronal development.

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the...

journal_title：Current opinion in cell biology

authors： Nicchitta CV

更新日期：2002-08-01 00:00:00

abstract：:Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression. ...

journal_title：Current opinion in cell biology

authors： Nigg EA

更新日期：1993-04-01 00:00:00

abstract：:The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...

journal_title：Current opinion in cell biology

authors： Remus D,Diffley JF

更新日期：2009-12-01 00:00:00

abstract：:Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and produce one differentiating daughter cell. One of the most prominent...

journal_title：Current opinion in cell biology

authors： Loyer N,Januschke J

更新日期：2020-02-01 00:00:00

abstract：:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...

journal_title：Current opinion in cell biology

authors： Schweizer N,Weiss M,Maiato H

更新日期：2014-06-01 00:00:00

abstract：:Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCF(Fbxw7) ubiquitin ligase, which is frequen...

journal_title：Current opinion in cell biology

authors： Kourtis N,Strikoudis A,Aifantis I

更新日期：2015-12-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the know...

journal_title：Current opinion in cell biology

authors： Weaver AM,Young ME,Lee WL,Cooper JA

更新日期：2003-02-01 00:00:00

abstract：:Autophagy is a crucial component of the cellular stress adaptation response that maintains mammalian homeostasis. Autophagy protects against neurodegenerative and inflammatory conditions, aging, and cancer. This is accomplished by the degradation and intracellular recycling of cellular components to maintain energy me...

journal_title：Current opinion in cell biology

authors： White E,Karp C,Strohecker AM,Guo Y,Mathew R

更新日期：2010-04-01 00:00:00

abstract：:Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking th...

journal_title：Current opinion in cell biology

authors： Wang B,Kundu M

更新日期：2017-04-01 00:00:00

abstract：:Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have...

journal_title：Current opinion in cell biology

authors： Sternweis PC

更新日期：1994-04-01 00:00:00

abstract：:Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and ...

journal_title：Current opinion in cell biology

authors： Hasson T,Cheney RE

更新日期：2001-02-01 00:00:00

abstract：:Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used throughout evolution to control the cellular responses to external signals such as growth factors, nutrient status, stress or inductive signals. Many important substrates for MAPKs are transcription factors, and both the genetic and the b...

journal_title：Current opinion in cell biology

authors： Treisman R

更新日期：1996-04-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...

journal_title：Current opinion in cell biology

authors： Yuan H,Yamashita YM

更新日期：2010-12-01 00:00:00

abstract：:The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)protein...

journal_title：Current opinion in cell biology

authors： Wassarman PM

更新日期：1995-10-01 00:00:00

abstract：:Several aspects of the interactions between growth factors and cell adhesion are described. Recent advances in the field come from the identification of molecules resembling growth factors or growth factor receptors, which bear cell adhesion motifs as well as molecules participating in both cell growth control and adh...

journal_title：Current opinion in cell biology

authors： Thiery JP,Boyer B

更新日期：1992-10-01 00:00:00

abstract：:The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and th...

journal_title：Current opinion in cell biology

authors： Herman IM

更新日期：1993-02-01 00:00:00

abstract：:1990 has been a year of continued exciting developments in cell cycle control. Progress has occurred in delineating the mechanism of activation of maturation-promoting factor during entry into mitosis and the mechanism of cyclin degradation responsible for exit from mitosis. Notable advances have also occurred in our ...

journal_title：Current opinion in cell biology

authors： Maller JL

更新日期：1991-04-01 00:00:00

abstract：:Analysis of complex and redundant pathways that control proliferation, differentiation, apoptosis and DNA damage response by global genome wide analysis is an intensive area of investigation aimed at identifying unique molecular signatures of prognostic significance in cancer. An alternative approach is to focus on th...

journal_title：Current opinion in cell biology

authors： Williams GH,Stoeber K

更新日期：2007-12-01 00:00:00

abstract：:The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm. Some of ORC's implied functions, such as cell ...

journal_title：Current opinion in cell biology

authors： Sasaki T,Gilbert DM

更新日期：2007-06-01 00:00:00

abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...

journal_title：Current opinion in cell biology

authors： Suter DM,Molina N,Naef F,Schibler U

更新日期：2011-12-01 00:00:00

abstract：:Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients pre...

journal_title：Current opinion in cell biology

authors： Majumdar R,Sixt M,Parent CA

更新日期：2014-10-01 00:00:00

abstract：:Mitochondria are classically known as the essential energy producers in cells. As such, the activation of mitochondrial metabolism upon cellular differentiation was deemed a necessity to fuel the high metabolic needs of differentiated cells. However, recent studies have revealed a direct role for mitochondrial activit...

journal_title：Current opinion in cell biology

authors： Khacho M,Slack RS

更新日期：2017-12-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:Inter-organelle membrane contact sites are zones where heterologous membranes, usually the endoplasmic reticulum plus a partner organelle, come into close apposition. These sites are very poorly understood because so few of their components have been identified; however, it is clear that they are specialised for traff...

journal_title：Current opinion in cell biology

authors： Levine T,Loewen C

更新日期：2006-08-01 00:00:00

abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...

journal_title：Current opinion in cell biology

authors： Surani MA

更新日期：1994-06-01 00:00:00