Neighborly relations during collective migration.

Abstract:

:The collective migration of sheets, cohorts, chains or streams of cells contributes to embryogenesis, tissue remodeling and repair as well as to cancer invasion. The functional coordination between neighboring cells is at the heart of collective migration, during which cells migrate with a similar speed in an identical direction. Far from being the result of the simultaneous migration of isolated cells, collective migration relies on the intercellular communication between migrating cells. Although the mechanisms of cell coordination are far from being completely understood, accumulated evidence show that exchange of mechanical and chemical information by direct intercellular contacts and by soluble extracellular signals orchestrate the coordinated behavior of collectively migrating cells.

journal_name

Curr Opin Cell Biol

authors

Etienne-Manneville S

doi

10.1016/j.ceb.2014.06.004

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

51-9

eissn

0955-0674

issn

1879-0410

pii

S0955-0674(14)00075-1

journal_volume

30

pub_type

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