Abstract:
:In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising arterial plasma glucose values. Epinephrine (220 mug/kg s.c.) and isoprenaline (10 mu/kg s.c.) enhanced arterial plasma glucose levels and increased mean renal glucose production significantly. The enhanced arterial plasma glucose levels and increased mean renal glucose production significantly. The enhanced glucose release after isoprenaline could be abolished by propranolol (1 mg/kg s.c.). The glycogen content of the kidney was found to be too small to account for the observed renal glucose release by glycogenolysis. Therefore, these in vivo data indicate enhanced renal gluconeogenesis after adrenergic stimulation. This effect is thought to be mediated by the beta-adrenergic receptors.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Greven J,van Eys B,Jacobs Wdoi
10.1159/000136914subject
Has Abstractpub_date
1975-01-01 00:00:00pages
265-71issue
3eissn
0031-7012issn
1423-0313journal_volume
13pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137488
更新日期:1981-01-01 00:00:00
abstract::Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137228
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000368559
更新日期:2014-01-01 00:00:00
abstract::Three doses (0.31, 3.1 and 31 mg/kg) of methotrexate (MTX) were given intravenously to rats. The resulting concentration-time curves in plasma (normalized by dividing the plasma concentration by a multiple of the dose) were not superimposable, indicating nonlinear plasma pharmacokinetics. In liver, kidney, bone marrow...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137723
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000360860
更新日期:2014-01-01 00:00:00
abstract:AIMS:To compare the bioavailability of a new oromucosal formulation of flurbiprofen 8.75-mg lozenges, developed by Alfa Wassermann S.p.A. (test drug) to that of marketed flurbiprofen 8.75-mg lozenges (Benactiv Gola®, reference drug). METHODS:This was an open, randomised, two-period, crossover, pharmacokinetic (PK) stu...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000336767
更新日期:2012-01-01 00:00:00
abstract::Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094521
更新日期:2006-01-01 00:00:00
abstract::Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139312
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND/AIMS:We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. METHODS:Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (5...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000316113
更新日期:2010-01-01 00:00:00
abstract::We investigated the antihypertensive effect of 5-HT1A agonist (buspirone) and 5-HT2B antagonists (SB204741 and SB200646) in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats. Experiments were divided into two sets: in the first set, sham-operated control and DOCA-treated hypertensive rats received busp...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000082114
更新日期:2005-03-01 00:00:00
abstract::The influence of hyperthyroidism on the functional vascular responsiveness of isolated coronary and renal resistance vessels was investigated. Hyperthyroidism was established by feeding rats for 1 and 4 weeks with 5 mg/kg L-thyroxine (T4)-containing rat chow. Preparations of either coronary or renal resistance vessels...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139519
更新日期:1997-09-01 00:00:00
abstract::Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000093790
更新日期:2006-01-01 00:00:00
abstract::The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000138507
更新日期:1988-01-01 00:00:00
abstract::The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138838
更新日期:1991-01-01 00:00:00
abstract::The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136839
更新日期:1978-01-01 00:00:00
abstract::The metabolism of sennosides is discussed in view of the results obtained during the last years. Rhein anthrone is to be considered as the ultimate active form produced by microorganisms in the colon. Several contributions of this senna symposium bring complementary information of utmost interest. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138431
更新日期:1988-01-01 00:00:00
abstract::Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138600
更新日期:1989-01-01 00:00:00
abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138136
更新日期:1985-01-01 00:00:00
abstract::A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the prep...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137598
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...
journal_title:Pharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000337383
更新日期:2012-01-01 00:00:00
abstract::This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3-100 μM) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) cont...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000320769
更新日期:2010-01-01 00:00:00
abstract::We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000084277
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000502789
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000453618
更新日期:2017-01-01 00:00:00
abstract::Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139468
更新日期:1997-01-01 00:00:00
abstract::A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137923
更新日期:1983-01-01 00:00:00
abstract::Supplementation of antioxidants such as vitamin E and vitamin C as health promotion food is popular recently. Epidemiological studies supported the beneficial effect of these antioxidants because oxygen free radicals have been linked to the process of diseases and aging. The present study evaluated the effect of alpha...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028330
更新日期:1999-11-01 00:00:00
abstract::The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138189
更新日期:1986-01-01 00:00:00
abstract::We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137543
更新日期:1981-01-01 00:00:00
abstract::The frequent resistance of malignant tumors to chemotherapy documents the fact that numerous patients are uselessly traumatized by highly toxic drugs. Investigations into this resistance have shown that many different mechanisms exist which can abolish the antitumor action of chemotherapeutics. So far, no safe method ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000112864
更新日期:2008-01-01 00:00:00