Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

abstract：:The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...

journal_title：Pharmacology

authors： Siddik ZH,Drew R,Litterst CL,Mimnaugh EG,Sikic BI,Gram TE

更新日期：1980-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：AIM:Superfluous reactive nitrogen and oxygen species generation is implicated in the damage of tissues at sites of inflammation where activated neutrophils and macrophages are involved. This study was conducted to investigate whether the beneficial effects of carvedilol involve modulation of respiratory burst, degranul...

journal_title：Pharmacology

authors： Pecivová J,Macicková T,Lojek A,Gallova L,Cíz M,Nosál' R,Holománová D

更新日期：2007-01-01 00:00:00

abstract：:Previous studies have indicated that structurally dissimilar serotonin2 (5HT2) antagonists can protect globally ischemic/reperfused reperfused rat hearts. We therefore determined if the 5HT2 antagonist cinanserin can protect the ischemic myocardium in two models of pacing-induced ischemia in anesthetized dogs. In one ...

journal_title：Pharmacology

authors： Grover GJ,Parham CS,Youssef S,Ogletree ML

更新日期：1995-05-01 00:00:00

abstract：:Amphetamine is a sympathomimetic and psychotropic drug which is extensively metabolized in liver and in brain. One of its major metabolites, p-hydroxyamphetamine, is accumulated by cortical and striatal synaptosomes. In order to learn whether p-hydroxyamphetamine can be further metabolized to a catecholamine, a sensit...

journal_title：Pharmacology

authors： Hoffman AR,Sastry BV,Axelrod J

更新日期：1979-01-01 00:00:00

abstract：:The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

journal_title：Pharmacology

authors： Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

更新日期：2002-01-01 00:00:00

abstract：:The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development. As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amo...

journal_title：Pharmacology

authors： Meissner U,Allabauer I,Repp R,Rascher W,Dötsch J

更新日期：2003-10-01 00:00:00

abstract：:We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally 10 and 30 min prior to ischemic i...

journal_title：Pharmacology

authors： Murakami F,Araki T,Kanai Y,Kato H,Fujiwara T,Kogure K

更新日期：1994-11-01 00:00:00

abstract：:The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...

journal_title：Pharmacology

authors： Johnson KM,Dewey WL

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

journal_title：Pharmacology

authors： Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

更新日期：2015-01-01 00:00:00

abstract：:The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...

journal_title：Pharmacology

authors： Dong P,Gu X,Zhu G,Li M,Ma B,Zi Y

更新日期：2018-01-01 00:00:00

abstract：:The oral bioavailability of two investigational formulations of bicalutamide was compared with the current clinical formulation. The first formulation was amorphous R-/S-bicalutamide in solid dispersion with a polymeric matrix of hydroxypropyl methylcellulose phthalate (HP55S) (R-/S-bicalutamide/HP55S); the second was...

journal_title：Pharmacology

authors： Cantarini M,Fuhr R,Morris T

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....

journal_title：Pharmacology

authors： Choi S,Lim JW,Kim H

更新日期：2020-01-01 00:00:00

abstract：:The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...

journal_title：Pharmacology

authors： Frey HH

更新日期：1986-01-01 00:00:00

abstract：:We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...

journal_title：Pharmacology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2013-01-01 00:00:00

abstract：:The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are ...

journal_title：Pharmacology

authors： Roederer M,Staal FJ,Ela SW,Herzenberg LA,Herzenberg LA

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Surgery plays a significant role in the comprehensive treatment of breast cancer, and opioids are often the first-choice analgesics in the perioperative period. However, recent studies showed that opioids may enhance the angiogenesis of breast cancer and the recurrence and metastasis of tumor cells. OBJECTI...

journal_title：Pharmacology

authors： Cheng S,Guo M,Liu Z,Fu Y,Wu H,Wang C,Cao M

更新日期：2019-01-01 00:00:00

abstract：:Various stressful stimuli cause mast cell degranulation. Hemorrhagic shock is one such stressful stimulus which may cause mast cell degranulation and histamine release. Histamine may be involved in the pathophysiology of hemorrhage. It was reported that there are large amounts of histamine in the anterior and posterio...

journal_title：Pharmacology

authors： Tikiz H,Tunçel N,Gürer F,Baycu C

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:The neurotransmitters participating in the nerve-mediated contraction of the guinea pig seminal vesicle (GPSV) have not been firmly established. There is debate as to the mediating role of norepinephrine and acetylcholine. METHODS:We have used longitudinally and circularly oriented strips of GPSV and a...

journal_title：Pharmacology

authors： Benko R,Szombati V,Bartho L

更新日期：2013-01-01 00:00:00

abstract：:Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma...

journal_title：Pharmacology

authors： Zerbe RL,Bayorh MA,Quirion R,Kopin IJ

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...

journal_title：Pharmacology

authors： Yildiz Akar F,Celikyurt IK,Ulak G,Mutlu O

更新日期：2009-01-01 00:00:00

abstract：:The effect of fenfluramine, administered orally in a daily dose of 1 mg/kg for 40 days, on the disposition and rate of elimination of antipyrine was studied in 15 obese patients. Although the plasma half-life of antipyrine was unchanged, the apparent volume of distribution (1/kg) fell by 11.6% (p less than 0.001) and ...

journal_title：Pharmacology

authors： O'Malley K,Stevenson IH,West M

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...

journal_title：Pharmacology

authors： Bourdon F,Lecoeur M,Lebègue N,Gressier B,Luyckx M,Odou P,Dine T,Goossens JF,Kambia N

更新日期：2014-01-01 00:00:00

abstract：AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...

journal_title：Pharmacology

authors： Chen FS,Satoh Y,Ide Y,Sugano T,Iimura M,Momose Y,Tsuchida K,Tagami M

更新日期：2012-01-01 00:00:00

abstract：:Ketotifen is an antiallergic drug and may have direct inhibitory effects on eosinophils. To investigate the anti-eosinophilic effect of ketotifen, we examined the effect of ketotifen on the production of reactive oxygen species (ROS) from eotaxin-primed human eosinophils. Ketotifen at 10(-10)-10(-6) mol/l significantl...

journal_title：Pharmacology

authors： Yamada Y,Sannohe S,Saito N,Cui CH,Ueki S,Oyamada H,Kanda A,Yamaguchi K,Hamada K,Adachi T,Kayaba H,Chihara J

更新日期：2003-11-01 00:00:00

abstract：AIMS:This study analyzed the role of the amiloride-sensitive component and the participation of the Na(+)/H(+) exchanger in renal responsiveness to vasoconstrictors in the isolated perfused rat kidney. METHODS:The renal responses to vasoconstrictors (angiotensin II, phenylephrine, vasopressin and KCl) were studied und...

journal_title：Pharmacology

authors： Vargas P,Wangensteen R,Rodríguez-Gómez I,Perez-Abud R,Osuna A,Quesada A,Vargas F

更新日期：2011-01-01 00:00:00

abstract：:Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol ...

journal_title：Pharmacology

authors： Nishiya H,Haga T,Nozue N,Komatsu T,Baba M,Ueda Y,Ono Y,Kunii O

更新日期：1989-01-01 00:00:00

abstract：:The effects of hypothermia (4 degrees C) on the components of the cholinergic system of the ileal longitudinal muscle and the adherent Auerbach's plexus of the guinea pig ileum have been investigated. Acetylcholine (ACh) content of the muscle was determined by pyrolysis-gas chromatography. It decreased from 119 to a f...

journal_title：Pharmacology

authors： Ochillo R,Rowell PP,Sastry BV

更新日期：1978-01-01 00:00:00

abstract：:The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...

journal_title：Pharmacology

authors： Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

更新日期：2000-01-01 00:00:00

abstract：:The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...

journal_title：Pharmacology

authors： Nègre-Salvayre A,Affany A,Hariton C,Salvayre R

更新日期：1991-01-01 00:00:00