听力与言语-语言病理学

行为科学

医学伦理学

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  • MTX Treatment Does Not Improve Outcome in Mice with AMI.

    abstract:BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...

    journal_title:Pharmacology

    pub_type: 新闻

    doi:10.1159/000511279

    authors: Dannenberg L,Trojovsky K,Ayhan A,Helten C,Zako S,M'Pembele R,Mourikis P,Benkhoff M,Ignatov D,Sarabhai T,Petzold T,Huhn-Wientgen R,Zeus T,Kelm M,Levkau B,Polzin A

    更新日期:2020-11-20 00:00:00

  • Trichostatin A Induces Autophagy in Cervical Cancer Cells by Regulating the PRMT5-STC1-TRPV6-JNK Pathway.

    abstract:OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000507937

    authors: Liu JH,Cao YM,Rong ZP,Ding J,Pan X

    更新日期:2020-11-03 00:00:00

  • Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis.

    abstract:INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000506488

    authors: Li TP,Sun SW,Xiong GZ,Qiu F,Yang DM,Sun SY,Xie XJ,Liao DF,Chen JX,Tuo QH

    更新日期:2020-07-21 00:00:00

  • Paeoniflorin on Rat Myocardial Ischemia Reperfusion Injury of Protection and Mechanism Research.

    abstract:OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000503583

    authors: Wu F,Ye B,Wu X,Lin X,Li Y,Wu Y,Tong L

    更新日期:2020-01-01 00:00:00

  • Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

    abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000502789

    authors: Watanabe Y,Ohata K,Fukanoki A,Fujimoto N,Matsumoto M,Nessa N,Toba H,Kobara M,Nakata T

    更新日期:2020-01-01 00:00:00

  • Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels.

    abstract::Vascular dementia (VaD) is the second most common type of dementia and has become a major public health challenge as the global population ages. VaD is caused by cerebrovascular disease, and most patients with VaD have been reported to also have Alzheimer's pathologies, which is the formation of neurofibrillary tangle...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000504056

    authors: Shi R,Zheng CB,Wang H,Rao Q,Du T,Bai C,Xiao C,Dai Z,Zhang C,Chen C,Li X,Tian M,Yu X,Ji B,Weng Z,Yang W

    更新日期:2020-01-01 00:00:00

  • Antiallodynic Effect of Intrathecal Korean Red Ginseng in Cisplatin-Induced Neuropathic Pain Rats.

    abstract:BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000503259

    authors: Kim YO,Song JA,Kim WM,Yoon MH

    更新日期:2020-01-01 00:00:00

  • Ameliorative Effect of Hochu-ekki-to on Natural Skin Aging.

    abstract:INTRODUCTION:Although it is beneficial to protect the skin from natural aging, especially in an aging society, the approach by which this can be achieved is still not well known. Hochu-ekki-to, a Chinese natural medicine, has various advantageous effects; however, there is no report about its influence on skin aging. ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000504985

    authors: Orita K,Yamate Y,Kobayashi H,Hiramoto K

    更新日期:2020-01-01 00:00:00

  • Floralozone Ameliorated Atherosclerosis in Experimental Atherosclerotic Rats Involved with Sphingosine 1-Phosphate 1 Enhancement.

    abstract::Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000504758

    authors: Yang YP,Zhu ML,Zhang HY,Song P,Xu J,Li P,Yin YL

    更新日期:2020-01-01 00:00:00

  • Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice.

    abstract:BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000505297

    authors: Wen G,Li T,He H,Zhou X,Zhu J

    更新日期:2020-01-01 00:00:00

  • Korean Red Ginseng Inhibits Amyloid-β-Induced Apoptosis and Nucling Expression in Human Neuronal Cells.

    abstract:INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000505592

    authors: Choi S,Lim JW,Kim H

    更新日期:2020-01-01 00:00:00

  • Lidocaine Reversible Inactivation of the Central Nucleus of Amygdala Impairs Acquisition, Consolidation, and Retrieval of Morphine State-Dependent Learning in Rat.

    abstract:BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000503726

    authors: Noorbakhshnia M,Rahmani-Samani P,Eivani M

    更新日期:2020-01-01 00:00:00

  • In vitro Antimicrobial Effects of Virus Block, Which Contains Multiple Polyoxometalate Compounds, and Hygienic Effects of Virus Block-Supplemented Moist Hand Towels.

    abstract:BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000500897

    authors: Dan K,Katoh N,Matsuoka T,Fujinami K

    更新日期:2019-06-06 00:00:00

  • Overexpression of Orphan Receptor GPR61 Increases cAMP Levels upon Forskolin Stimulation in HEK293 Cells: in vitro and in silico Validation of 5-(Nonyloxy)Tryptamine as a Low-Affinity Inverse Agonist.

    abstract::GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000501926

    authors: Kozielewicz P,Grafton G,Sajkowska-Kozielewicz JJ,Barnes NM

    更新日期:2019-01-01 00:00:00

  • Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters.

    abstract:BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000494058

    authors: Castellão-Santana LM,Yumi Abiko P,Ambiel CR,Peixoto AR,Noronha-Matos JB,Correia-de-Sá P,Alves-Do-Prado W

    更新日期:2019-01-01 00:00:00

  • Prevention of Stent Thrombosis in Rats by a Direct Oral Factor Xa Inhibitor Edoxaban.

    abstract:BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000494059

    authors: Morishima Y,Honda Y,Kamisato C

    更新日期:2019-01-01 00:00:00

  • Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients.

    abstract:OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000500314

    authors: Alqahtani S,Alzaidi T,Alotaibi M,Alsultan A

    更新日期:2019-01-01 00:00:00

  • Morphine Promotes the Angiogenesis of Postoperative Recurrent Tumors and Metastasis of Dormant Breast Cancer Cells.

    abstract:BACKGROUND:Surgery plays a significant role in the comprehensive treatment of breast cancer, and opioids are often the first-choice analgesics in the perioperative period. However, recent studies showed that opioids may enhance the angiogenesis of breast cancer and the recurrence and metastasis of tumor cells. OBJECTI...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000502107

    authors: Cheng S,Guo M,Liu Z,Fu Y,Wu H,Wang C,Cao M

    更新日期:2019-01-01 00:00:00

  • Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling.

    abstract::The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000492576

    authors: Dong P,Gu X,Zhu G,Li M,Ma B,Zi Y

    更新日期:2018-01-01 00:00:00

  • Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes.

    abstract::Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000487892

    authors: Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

    更新日期:2018-01-01 00:00:00

  • Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling.

    abstract::Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000488083

    authors: Husain N,Yabuki Y,Shinoda Y,Fukunaga K

    更新日期:2018-01-01 00:00:00

  • Once-a-Day Trazodone in the Treatment of Depression in Routine Clinical Practice.

    abstract:OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...

    journal_title:Pharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000492079

    authors: Češková E,Šedová M,Kellnerová R,Starobová O

    更新日期:2018-01-01 00:00:00

  • Periplaneta Americana Extract May Attenuate Renal Fibrosis through Inhibiting Janus Tyrosine Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway.

    abstract:BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000488535

    authors: Liu J,Zhou L,He L,Zhong Y,Zhang X,Xiao B,Liu G

    更新日期:2018-01-01 00:00:00

  • The Efficacy of Rituximab Combined with 131I for Ophthalmic Outcomes of Graves' Ophthalmopathy Patients.

    abstract:PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...

    journal_title:Pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000453618

    authors: Li J,Xiao Z,Hu X,Li Y,Zhang X,Zhang S,Gong W,Zhao J,Ye X

    更新日期:2017-01-01 00:00:00

  • The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice.

    abstract::We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The o...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000455916

    authors: Haruna T,Soga M,Morioka Y,Imura K,Furue Y,Yamamoto M,Hayakawa J,Deguchi M,Arimura A,Yasui K

    更新日期:2017-01-01 00:00:00

  • Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen.

    abstract:BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000477971

    authors: Zhang J,Song H,Jiang S,Chen Z,Tong S,Lin F,Wen C,Zhang X,Hu L

    更新日期:2017-01-01 00:00:00

  • Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review.

    abstract::Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...

    journal_title:Pharmacology

    pub_type: 杂志文章,评审

    doi:10.1159/000448247

    authors: Campins L,Camps M,Riera A,Pleguezuelos E,Yebenes JC,Serra-Prat M

    更新日期:2017-01-01 00:00:00

  • The Small Molecule Indirubin-3'-Oxime Inhibits Protein Kinase R: Antiapoptotic and Antioxidant Effect in Rat Cardiac Myocytes.

    abstract::Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000441727

    authors: Udumula MP,Medapi B,Dhar I,Bhat A,Desai K,Sriram D,Dhar A

    更新日期:2016-01-01 00:00:00

  • Effect of Angiotensin-(1-7) on Aortic Response, TNF-α, IL-1β and Receptor for Advanced Glycation Endproduct in Rat's Adjuvant-Induced Arthritis.

    abstract::Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000444188

    authors: Açikalin Ö,Bölükbaşi Hatip FF,Tan RF,Hatip-Al-Khatib I

    更新日期:2016-01-01 00:00:00

  • Effects of Polybrominated Diphenyl Ethers on Rat and Human 11β-Hydroxysteroid Dehydrogenase 1 and 2 Activities.

    abstract::Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000445213

    authors: Chen X,Dong Y,Cao S,Li X,Wang Z,Chen R,Ge RS

    更新日期:2016-01-01 00:00:00

  • Combination of Sitagliptin and Insulin against Type 2 Diabetes Mellitus with Neuropathy in Rats: Neuroprotection and Role of Oxidative and Inflammation Stress.

    abstract:AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000448043

    authors: Kelany ME,Hakami TM,Omar AH,Abdallah MA

    更新日期:2016-01-01 00:00:00

  • Enalapril Associated with Furosemide Induced Acute Kidney Injury in an Infant with Heart Failure. A Case Report, a Revision of the Literature and a Pharmacovigilance Database Analysis.

    abstract::The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000441950

    authors: Fabiano V,Carnovale C,Gentili M,Radice S,Zuccotti GV,Clementi E,Perrotta C,Mameli C

    更新日期:2016-01-01 00:00:00

  • The Alcohol Intolerance Produced by Isoniazid Is Not Due to a Disulfiram-Like Reaction Despite Aldehyde Dehydrogenase Inhibition.

    abstract:BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000448759

    authors: Karamanakos PN,Pappas P,Boumba V,Vougiouklakis T,Marselos M

    更新日期:2016-01-01 00:00:00

  • Combined Inhibition of Histamine H1 Receptors and Leukotrienes Reduces Compound 48/80-Induced Contraction of the Human Bronchus in vitro.

    abstract:BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000440769

    authors: Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

    更新日期:2015-01-01 00:00:00

  • Fenofibrate treatment attenuated chronic endoplasmic reticulum stress in the liver of nonalcoholic fatty liver disease mice.

    abstract::Fenofibrate is widely used in clinical practice, but its influence on chronic endoplasmic reticulum (ER) stress induced by feeding a high-calorie and high-cholesterol diet (HCD) has still not been studied. We thus investigated its effects on the liver of the nonalcoholic fatty liver disease (NAFLD) mouse model. Male C...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000380952

    authors: Zhang N,Lu Y,Shen X,Bao Y,Cheng J,Chen L,Li B,Zhang Q

    更新日期:2015-01-01 00:00:00

  • Introducing Female Black Swiss Mice: Minimal Effects of Sex in a Strain-Specific Battery of Tests for Mania-Like Behavior and Response to Lithium.

    abstract::Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000381785

    authors: Ene HM,Kara NZ,Einat H

    更新日期:2015-01-01 00:00:00

  • Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells.

    abstract:BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000365932

    authors: Siuda D,Tobias S,Rus A,Xia N,Förstermann U,Li H

    更新日期:2014-01-01 00:00:00

  • Resting energy expenditure and the clearance of therapeutic proteins in pediatric subjects.

    abstract::The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000362562

    authors: Lee SK

    更新日期:2014-01-01 00:00:00

  • Drug fever due to a single dose of pantoprazole.

    abstract::Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000364781

    authors: Schiller D,Maieron A,Schöfl R,Donnerer J

    更新日期:2014-01-01 00:00:00

  • Pharmacokinetic evaluation of a novel benzopyridooxathiazepine derivative as a potential anticancer agent.

    abstract:BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000368084

    authors: Bourdon F,Lecoeur M,Lebègue N,Gressier B,Luyckx M,Odou P,Dine T,Goossens JF,Kambia N

    更新日期:2014-01-01 00:00:00

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