解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...
journal_title:Pharmacology
pub_type: 新闻
doi:10.1159/000511279
更新日期:2020-11-20 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000507937
更新日期:2020-11-03 00:00:00
abstract:INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000506488
更新日期:2020-07-21 00:00:00
abstract:OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000503583
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000502789
更新日期:2020-01-01 00:00:00
abstract::Vascular dementia (VaD) is the second most common type of dementia and has become a major public health challenge as the global population ages. VaD is caused by cerebrovascular disease, and most patients with VaD have been reported to also have Alzheimer's pathologies, which is the formation of neurofibrillary tangle...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000504056
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000503259
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Although it is beneficial to protect the skin from natural aging, especially in an aging society, the approach by which this can be achieved is still not well known. Hochu-ekki-to, a Chinese natural medicine, has various advantageous effects; however, there is no report about its influence on skin aging. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000504985
更新日期:2020-01-01 00:00:00
abstract::Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000504758
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000505297
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000505592
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000503726
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000500897
更新日期:2019-06-06 00:00:00
abstract::GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000501926
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000494058
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000494059
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000500314
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Surgery plays a significant role in the comprehensive treatment of breast cancer, and opioids are often the first-choice analgesics in the perioperative period. However, recent studies showed that opioids may enhance the angiogenesis of breast cancer and the recurrence and metastasis of tumor cells. OBJECTI...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000502107
更新日期:2019-01-01 00:00:00
abstract::The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000492576
更新日期:2018-01-01 00:00:00
abstract::Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000487892
更新日期:2018-01-01 00:00:00
abstract::Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488083
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究
doi:10.1159/000492079
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488535
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000453618
更新日期:2017-01-01 00:00:00
abstract::We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000455916
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000477971
更新日期:2017-01-01 00:00:00
abstract::Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000448247
更新日期:2017-01-01 00:00:00
abstract::Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441727
更新日期:2016-01-01 00:00:00
abstract::Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000444188
更新日期:2016-01-01 00:00:00
abstract::Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000445213
更新日期:2016-01-01 00:00:00
abstract:AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000448043
更新日期:2016-01-01 00:00:00
abstract::The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441950
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000448759
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000440769
更新日期:2015-01-01 00:00:00
abstract::Fenofibrate is widely used in clinical practice, but its influence on chronic endoplasmic reticulum (ER) stress induced by feeding a high-calorie and high-cholesterol diet (HCD) has still not been studied. We thus investigated its effects on the liver of the nonalcoholic fatty liver disease (NAFLD) mouse model. Male C...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000380952
更新日期:2015-01-01 00:00:00
abstract::Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000381785
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000365932
更新日期:2014-01-01 00:00:00
abstract::The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000362562
更新日期:2014-01-01 00:00:00
abstract::Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000364781
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000368084
更新日期:2014-01-01 00:00:00