Influence of the selective cholecystokinin antagonist L-364,718 on pain threshold and morphine analgesia.

abstract：OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...

journal_title：Pharmacology

authors： Češková E,Šedová M,Kellnerová R,Starobová O

更新日期：2018-01-01 00:00:00

abstract：:This study tests the hypothesis that contractile responses in aortae of hypertensive rats are more dependent on gap junctional communication compared to those from normotensive rats. The experimental approach was pharmacological, using inhibitors of gap junctional activity (heptanol and octanol). Two models of experim...

journal_title：Pharmacology

authors： Leite R,Webb RC

更新日期：2001-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance. At this stage of pregnancy, the ovine genital tract prese...

journal_title：Pharmacology

authors： Garcia-Villar R

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of...

journal_title：Pharmacology

authors： Morishima Y,Honda Y,Kamisato C

更新日期：2019-01-01 00:00:00

abstract：:The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, wa...

journal_title：Pharmacology

authors： Cavaliere TA,Taylor DG,Kerwin LJ,Antonaccio MJ

更新日期：1980-01-01 00:00:00

abstract：:Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol fail...

journal_title：Pharmacology

authors： Smith DF,Shimizu M,Schou M

更新日期：1977-01-01 00:00:00

abstract：:Regional cerebral metabolic rates of glucose (rCMRglu) were measured in conscious rats grouped according to three treatments: control, bicuculline (5.5 mg/kg s.c.), and intracerebroventricular arginine vasopressin (0.5 micrograms/5 microliter). Rats in the latter group were pre-exposed to the peptide 48 h earlier to r...

journal_title：Pharmacology

authors： Wurpel JN,Dundore RL,Bryan RM Jr,Keil LC,Severs WB

更新日期：1988-01-01 00:00:00

abstract：:The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-...

journal_title：Pharmacology

authors： Bomfim JH,de Godoy MA,Giglio JR,de Oliveira AM,Arantes EC

更新日期：2005-03-01 00:00:00

abstract：:Previously it was demonstrated that intravenously administered morphine produced greater analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison to 8-week-old rats. The differential pharmacological responses to morphine could not solely be attributed to the pharmacokinetic parameters, ...

journal_title：Pharmacology

authors： Bhargava HN,Villar VM,Rahmani NH,Larsen AK

更新日期：1993-07-01 00:00:00

abstract：:The antinociceptive effect in mice (hot-plate test) of caerulein (0.15 mg/kg s.c.) was many times more resistant to naloxone than that of morphine (2 mg/kg s.c., equipotent with the caerulein dose). The ED50 (mg/kg s.c.) of naloxone (given simultaneously with an agonist) was with morphine 0.01 and with caerulein 0.07....

journal_title：Pharmacology

authors： Zetler G

更新日期：1982-01-01 00:00:00

abstract：:A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...

journal_title：Pharmacology

authors： Wickstrøm E,Barbo SE,Dreyfus JF,Jerkø D,Kleiven R,Slåttbrekk R,Stray Tønnesen JN

更新日期：1983-01-01 00:00:00

abstract：:The purpose of the study was to test the hypothesis that the postischemic neuronal damage is accompanied by changes of the electrocorticogram (ECoG) of freely moving rats during long-term recovery after forebrain ischemia. Ten minutes forebrain ischemia was induced in male Wistar rats. ECoG was recorded 1 day before a...

journal_title：Pharmacology

authors： Peruche B,Klaassens H,Krieglstein J

更新日期：1995-04-01 00:00:00

abstract：:Oxygen radicals have been considered to be important regulatory molecules in Helicobacter pylori-induced gastric ulceration and carcinogenesis. H. pylori-induced inflammation has been shown to be associated with cyclooxygenase-2 (COX-2) expression in experimental animals and human patients. This study aimed to determi...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：2002-12-01 00:00:00

abstract：:The present study was carried out to test bioequivalence between two different oral desmopressin formulations. Sixty healthy volunteers were enrolled in the study and were randomly assigned to receive the test (T) and reference (R) drug in a two-period two-sequence, crossover, analyst-blinded study design. Subjects re...

journal_title：Pharmacology

authors： Kaehler ST,Steiner IM,Sauermann R,Scheidl H,Mueller M,Joukhadar C

更新日期：2006-01-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：:In a randomized three-phase crossover study, 12 healthy male volunteers were given three 12-hourly 500-mg doses of erythromycin base, as enteric coated pellets in capsules (2 X 250 mg), erythromycin stearate tablet (1 X 500 mg), or erythromycin ethylsuccinate sachet (1 X 500 mg). The reaction time after administration...

journal_title：Pharmacology

authors： Tjandramaga TB,Van Hecken A,Mullie A,Verbesselt R,De Schepper PJ,Verbist L,Josefsson K

更新日期：1984-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:Vascular dementia (VaD) is the second most common type of dementia and has become a major public health challenge as the global population ages. VaD is caused by cerebrovascular disease, and most patients with VaD have been reported to also have Alzheimer's pathologies, which is the formation of neurofibrillary tangle...

journal_title：Pharmacology

authors： Shi R,Zheng CB,Wang H,Rao Q,Du T,Bai C,Xiao C,Dai Z,Zhang C,Chen C,Li X,Tian M,Yu X,Ji B,Weng Z,Yang W

更新日期：2020-01-01 00:00:00

abstract：:Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total c...

journal_title：Pharmacology

authors： Borgå O,Juhlin-Dannfeldt A,Dahlqvist R

更新日期：1978-01-01 00:00:00

abstract：:The effect of repeated administration of U-50,488H, a kappa-opioid receptor agonist, on the development of tolerance to its analgesic effect and on the 5-HT1 and 5-HT2 receptors in the cerebral cortex and spinal cord of the rat were determined. Male Sprague-Dawley rats were injected twice daily with U-50,488H, (25 mg/...

journal_title：Pharmacology

authors： Gulati A,Ramarao P,Bhargava HN

更新日期：1989-01-01 00:00:00

abstract：:Using a discrete-trial avoidance-escape schedule in rats the interactions of morphine (M), chlorpromazine (C) and Haloperidol (H) were studied. All three drugs given alone or in combination disrupted operant behavior. At low doses C and H potentiated each other's effect, while at high doses antagonism could be observe...

journal_title：Pharmacology

authors： Tarnawa I,Székely JI

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) presents a problem in cancer chemotherapy, and developing new agents to overcome MDR is important. This study intends to investigate the reversal effect of -elemene on MDR in human breast carcinoma MCF-7 and doxorubicin-resistant MCF-7 cells. METHODS:MTT cytotoxicity assays, flow ...

journal_title：Pharmacology

authors： Xu HB,Li L,Fu J,Mao XP,Xu LZ

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

journal_title：Pharmacology

authors： Kim YO,Song JA,Kim WM,Yoon MH

更新日期：2020-01-01 00:00:00

abstract：:The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...

journal_title：Pharmacology

authors： Steinmann U,Estler CJ,Dann O

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...

journal_title：Pharmacology

authors： Wen G,Li T,He H,Zhou X,Zhu J

更新日期：2020-01-01 00:00:00

abstract：:Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that ca...

journal_title：Pharmacology

authors： Dai S,Ogle CW,Cho CH

更新日期：1986-01-01 00:00:00

abstract：:Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...

journal_title：Pharmacology

authors： Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

更新日期：2011-01-01 00:00:00

abstract：:We investigated the antihypertensive effect of 5-HT1A agonist (buspirone) and 5-HT2B antagonists (SB204741 and SB200646) in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats. Experiments were divided into two sets: in the first set, sham-operated control and DOCA-treated hypertensive rats received busp...

journal_title：Pharmacology

authors： Shingala JR,Balaraman R

更新日期：2005-03-01 00:00:00