Abstract:
:Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that carbenoxolone significantly stimulated both gastric and duodenal mucus synthesis. It is suggested that carbenoxolone may also effectively increase mucus synthesis and probably accelerate ulcer healing in the duodenum if sufficient amounts can escape gastric absorption and reach this region.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Dai S,Ogle CW,Cho CHdoi
10.1159/000138201subject
Has Abstractpub_date
1986-01-01 00:00:00pages
58-60issue
1eissn
0031-7012issn
1423-0313journal_volume
33pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The transketolase activity (TKA) of the white and red blood cells of oral contraceptive users was studied in an unselected sample population. Compared with healthy controls of corresponding age, the white cell TKA in the oral contraceptive groups was lowered in about 30%. The red cell TKA was lowered in about 15% of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136475
更新日期:1974-01-01 00:00:00
abstract::The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056148
更新日期:2002-01-01 00:00:00
abstract::The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000362459
更新日期:2014-01-01 00:00:00
abstract::High-affinity (104 +/- 18 pmol/l) and high-density (204 +/- 25 fmol/mg) angiotensin II (AII) binding sites have been identified in Xenopus laevis heart membranes. Competition binding of [125I]Sar1,Ile8 angiotensin (SIA) to these receptors by peptide analogs selective for the mammalian AII receptor subtypes AT1 and AT2...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139186
更新日期:1994-04-01 00:00:00
abstract::The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136787
更新日期:1978-01-01 00:00:00
abstract::Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of metabolism. The present studies were done to determine the basis for this distribution. Among the enzyma...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028384
更新日期:2000-08-01 00:00:00
abstract::DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137250
更新日期:1979-01-01 00:00:00
abstract::Maternal smoking during pregnancy causes reduction of fetal breathing movements, an effect attributed to nicotine in fetal blood. Nicotine is metabolized to cotinine which has a long plasma half-life and exhibits slow clearance across membrane barriers. It is also known to activate placental phospholipase-A2-like enzy...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028231
更新日期:1998-08-01 00:00:00
abstract::The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138804
更新日期:1991-01-01 00:00:00
abstract::The present study was designed to investigate the effects of fluid administration on survival in endotoxemic or septicemic male Sprague-Dawley rats. Endotoxemia was induced by intravenous injection of Escherichia coli lipopolysaccharide (LPS), and septicemia produced by cecal ligation and puncture (CLP). In endotoxemi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139053
更新日期:1993-05-01 00:00:00
abstract:INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000506488
更新日期:2020-07-21 00:00:00
abstract::This study was designed to document possible changes in the binding of bupivacaine (BV), lidocaine (LC) and their main metabolites desbutylbupivacaine (PPX) and monoethylglycinexylydide (MEGX), respectively, to plasma proteins and erythrocytes in mice after acute treatment with the calcium antagonists diltiazem (DZ), ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139433
更新日期:1996-10-01 00:00:00
abstract::The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056163
更新日期:2002-01-01 00:00:00
abstract::A multicenter, placebo-controlled, double-dummy, randomized, parallel-group, double-blind study was conducted to verify the hypothesis of noninferiority for single-dose administration of zaltoprofen 160 mg, a nonsteroidal anti-inflammatory drug, compared with loxoprofen sodium 60 mg (loxoprofen), in terms of antipyret...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000324532
更新日期:2011-01-01 00:00:00
abstract::We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094900
更新日期:2006-01-01 00:00:00
abstract::The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138385
更新日期:1988-01-01 00:00:00
abstract::In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000092308
更新日期:2006-01-01 00:00:00
abstract::Extracellular ATP regulates cell proliferation, muscle contraction and myoblast differentiation. ATP present in the muscle interstitium can be released from contracting skeletal muscle cells. L-Carnitine is a key element in muscle cell metabolism, as it serves as a carrier for fatty acid through mitochondrial membrane...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000114449
更新日期:2008-01-01 00:00:00
abstract::GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000501926
更新日期:2019-01-01 00:00:00
abstract::We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000084277
更新日期:2005-06-01 00:00:00
abstract::This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028223
更新日期:1998-07-01 00:00:00
abstract::Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000364781
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000110555
更新日期:2008-01-01 00:00:00
abstract::The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous infusion of carvedilol or labetalol at a rate of 10 micrograms/kg/min resulted...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138719
更新日期:1990-01-01 00:00:00
abstract::Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating....
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000136769
更新日期:1978-01-01 00:00:00
abstract::The isolated longitudinal muscle preparation (with attached Auerbach plexus) of the guinea pig ileum was used to investigate the structure activity relationship and kinetics of some naloxone and naltrexone derivatives and that of cyclazocine. The agonist used for the investigation of the antagonistic effect of these c...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136582
更新日期:1976-01-01 00:00:00
abstract::The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000330742
更新日期:2011-01-01 00:00:00
abstract::The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136728
更新日期:1977-01-01 00:00:00
abstract::Nabumetone is a nonsteroidal anti-inflammatory (NSAI) drug which is known to cause less gastrointestinal damage than other NSAI drugs. This study was performed to evaluate whether nabumetone treatment might alter the vascular aberrations related to inflammation in a rat model of adjuvant-induced arthritis. Nabumetone ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028358
更新日期:2000-04-01 00:00:00
abstract::The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441950
更新日期:2016-01-01 00:00:00