Abstract:
:The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly to the hypnotic benefits of ramelteon. We assessed the ramelteon-like activity of M-II in vitro and in vivo using cats. Binding and functional studies in Chinese hamster ovary cells expressing human melatonin receptors (MT1 or MT2) revealed that M-II binds melatonin receptors with lower affinity (Ki: 114 and 566 pmol/l for MT1 and MT2, respectively) and has lower potency (IC50: 208 and 1,470 pmol/l for MT1 and MT2, respectively) compared with ramelteon. However, higher M-II doses significantly improved sleep in cats. Thus, M-II may contribute to the clinical efficacy of ramelteon.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Nishiyama K,Nishikawa H,Kato K,Miyamoto M,Tsukamoto T,Hirai Kdoi
10.1159/000362459subject
Has Abstractpub_date
2014-01-01 00:00:00pages
197-201issue
3-4eissn
0031-7012issn
1423-0313pii
000362459journal_volume
93pub_type
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