Abstract:
:In gross behavioral observation the minimum effective dose of zopiclone was intravenously 0.06-0.25 mg/kg and intragastrically 1-4 mg/kg in rhesus monkeys. Zopiclone suppressed barbital withdrawal signs of rhesus monkeys at a single dose of 16 mg/kg or more. The suppressing effect of zopiclone 32 mg/kg i.g. was comparable to diazepam 8 mg/kg. Crab-eating monkeys treated with zopiclone at doses up to 32 mg/kg twice daily for up to 8 weeks manifested intermediate-grade signs upon withdrawal (i.e., less severe than after treatment with diazepam and similar to nitrazepam). Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Yanagita Tdoi
10.1159/000137930subject
Has Abstractpub_date
1983-01-01 00:00:00pages
216-27eissn
0031-7012issn
1423-0313journal_volume
27 Suppl 2pub_type
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