Cardiovascular depression by verapamil: reversal by glucagon and interactions with propranolol.

abstract：:Both in vivo and in vitro exposure to morphine have been reported to produce a number of immunomodulatory effects in both laboratory animals and humans. The current study was performed to assess the direct in vitro effect of exposure to morphine or morphine metabolites on immune response parameters. Murine B6C3F1 sple...

journal_title：Pharmacology

authors： Thomas PT,Bhargava HN,House RV

更新日期：1995-01-01 00:00:00

abstract：:The influence of hyperthyroidism on the functional vascular responsiveness of isolated coronary and renal resistance vessels was investigated. Hyperthyroidism was established by feeding rats for 1 and 4 weeks with 5 mg/kg L-thyroxine (T4)-containing rat chow. Preparations of either coronary or renal resistance vessels...

journal_title：Pharmacology

authors： Zwaveling J,Pfaffendorf M,van Zwieten PA

更新日期：1997-09-01 00:00:00

abstract：:We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK(1) and NK(2) receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotrien...

journal_title：Pharmacology

authors： Tanpo T,Nabe T,Yasui K,Kamiki T,Kohno S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00

abstract：:Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol fail...

journal_title：Pharmacology

authors： Smith DF,Shimizu M,Schou M

更新日期：1977-01-01 00:00:00

abstract：:Several attempts have been made in order to classify the gastrointestinal motility disorders; they are mainly based upon the type of disorder in transit and the region of the gastrointestinal tract affected. Many digestive motor disturbances do not constitute entities, but are pathophysiologic mechanisms that may cont...

journal_title：Pharmacology

authors： Buéno L,Frexinos J,Fioramonti J

更新日期：1988-01-01 00:00:00

abstract：:Cinnamedrine is an active ingredient in preparations used to relieve dysmenorrhea. It has been reported to have local anesthetic properties in nerve. This property prompted us to evaluate the effects of cinnamedrine on the cardiac action potential. Cinnamedrine (10-35 microM) significantly reduced the overshoot and ma...

journal_title：Pharmacology

authors： Arena JP,McArdle JJ,Argentieri TM

更新日期：1987-01-01 00:00:00

abstract：:The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...

journal_title：Pharmacology

authors： Sirek A,Sirek OV,Policova Z,Kerekes A

更新日期：1977-01-01 00:00:00

abstract：AIM:To study whether rosiglitazone prevents the development of diabetic nephropathy through reduction of reactive oxygen species and its downstream signal transduction pathways. METHODS:The rats were intraperitoneally injected with streptozotocin to induce diabetes, meanwhile the rats in the therapeutic groups were gi...

journal_title：Pharmacology

authors： Bao Y,Jia RH,Yuan J,Li J

更新日期：2007-01-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...

journal_title：Pharmacology

authors： Chen FS,Satoh Y,Ide Y,Sugano T,Iimura M,Momose Y,Tsuchida K,Tagami M

更新日期：2012-01-01 00:00:00

abstract：:In the present study, the effects of ghrelin against the gastric damage induced by intragastric administration of 0.6 N HCl and the involvement of histamine H₃ receptors (H₃Rs) were investigated in conscious rats with selective H₃R ligands. Intraperitoneal (i.p.) injection of ghrelin (40 μg/kg) significantly reduced (...

journal_title：Pharmacology

authors： Adami M,Pozzoli C,Leurs R,Stark H,Coruzzi G

更新日期：2010-01-01 00:00:00

abstract：:A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykin...

journal_title：Pharmacology

authors： Mastrangelo D,Mathison R,Huggel H

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The primary aim of the present investigation was to determine and compare the pharmacokinetic (PK) profiles of inorganic phosphate in serum and urine after intravenous administration of sodium glycerophosphate and inorganic sodium phosphate. Additionally, study product safety profiles were evaluated. SUBJECT...

journal_title：Pharmacology

authors： Topp H,Hochfeld O,Bark S,Grossmann M,Joukhadar C,Westphal M,Straatsma H,Rothenburger M

更新日期：2011-01-01 00:00:00

abstract：:Supplementation of antioxidants such as vitamin E and vitamin C as health promotion food is popular recently. Epidemiological studies supported the beneficial effect of these antioxidants because oxygen free radicals have been linked to the process of diseases and aging. The present study evaluated the effect of alpha...

journal_title：Pharmacology

authors： Huang W,Chan P,Chen Y,Chen C,Liao S,Chin W,Cheng J

更新日期：1999-11-01 00:00:00

abstract：:The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...

journal_title：Pharmacology

authors： Vargas F,Haro JM,Garcia-Torres L,Soler A,Garcia del Rio C

更新日期：1989-01-01 00:00:00

abstract：:High-affinity (104 +/- 18 pmol/l) and high-density (204 +/- 25 fmol/mg) angiotensin II (AII) binding sites have been identified in Xenopus laevis heart membranes. Competition binding of [125I]Sar1,Ile8 angiotensin (SIA) to these receptors by peptide analogs selective for the mammalian AII receptor subtypes AT1 and AT2...

journal_title：Pharmacology

authors： Aiyar N,Baker E,Pullen M,Nuthulaganti P,Bergsma DJ,Kumar C,Nambi P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...

journal_title：Pharmacology

authors： Yildiz Akar F,Celikyurt IK,Ulak G,Mutlu O

更新日期：2009-01-01 00:00:00

abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...

journal_title：Pharmacology

authors： Marumo F,Nara Y

更新日期：1987-01-01 00:00:00

abstract：:Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have less than 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to...

journal_title：Pharmacology

authors： MacCannell KL,Lederis K,Hamilton PL,Rivier J

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

journal_title：Pharmacology

authors： Dan K,Katoh N,Matsuoka T,Fujinami K

更新日期：2019-06-06 00:00:00

abstract：:In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...

journal_title：Pharmacology

authors： DeMoraes S,Capaz FR

更新日期：1977-01-01 00:00:00

abstract：:GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...

journal_title：Pharmacology

authors： Kozielewicz P,Grafton G,Sajkowska-Kozielewicz JJ,Barnes NM

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to determine whether transforming growth factor-beta1 (TGF-beta1) induces the synthesis, release and gene expression of urokinase-type plasminogen activator (uPA) in hepatic stellate cells. In addition to stimulating collagen production, TGF-beta1 induced the morphological and phenotypical ch...

journal_title：Pharmacology

authors： Pérez-Liz G,Flores-Hernández J,Arias-Montaño JA,Reyes-Esparza JA,Rodríguez-Fragoso L

更新日期：2005-01-01 00:00:00

abstract：:The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...

journal_title：Pharmacology

authors： Feldman S,Putcha L

更新日期：1977-01-01 00:00:00

abstract：:The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non-peptide tachykinin receptor antagonists, were examined and compared to those of FK-888 and GR-159897. Since no functional NK(3) receptors were found in the rat bladder, the emphasis will be on the...

journal_title：Pharmacology

authors： Choppin A,Groke G,Bringas A,Stepan G,Dillon MP

更新日期：2002-05-01 00:00:00

abstract：:Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vit...

journal_title：Pharmacology

authors： Strandberg TE,Kuusi T,Tilvis RS,Miettinen TA

更新日期：1983-01-01 00:00:00

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：:Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulati...

journal_title：Pharmacology

authors： Altavilla D,Polito F,Bitto A,Minutoli L,Miraldi E,Fiumara T,Biagi M,Marini H,Giachetti D,Vaccaro M,Squadrito F

更新日期：2008-01-01 00:00:00

abstract：:Various attempts to developing antagonists for substance P (SP) and related peptides, based on our past experience with angiotensin, kinins, and neurotensin, were unsuccessful. The particular features of SP, namely the high activity of C-terminal partial sequences in some pharmacological tests were used to develop one...

journal_title：Pharmacology

authors： Regoli D,Escher E,Mizrahi J

更新日期：1984-01-01 00:00:00