Abstract:
:We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK(1) and NK(2) receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotriene antagonist. SR-48968 but not CP-96345, significantly inhibited the late phase of the bronchial contraction. Phosphoramidon, a neutral endopeptidase inhibitor, tended to potentiate bronchial contraction. Posttreatment with SR-48968 decreased the enhanced contraction induced by the inhibitor as well as the nonenhanced contraction to similar levels of tension. On the other hand, antigen-induced tracheal contraction was not altered by either neuropeptide antagonist. These results suggest that neuropeptides mediate the antigen-induced contractile response of the guinea pig bronchus partly through NK(2) receptor stimulation.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Tanpo T,Nabe T,Yasui K,Kamiki T,Kohno Sdoi
10.1159/000028365subject
Has Abstractpub_date
2000-05-01 00:00:00pages
169-74issue
4eissn
0031-7012issn
1423-0313pii
28365journal_volume
60pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137758
更新日期:1982-01-01 00:00:00
abstract::TRK-530 is a novel synthetic bisphosphonate compound which exhibits inhibitory activity in the rat adjuvant arthritis (AA) model. We found that, during AA development, the concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and tumor necrosis factor alpha (TNF-alpha) in the bone marrow increased, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028203
更新日期:1998-05-01 00:00:00
abstract::Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-mescaline in the pellet. 1.33 mumol/ml of chlorpromazine, trifluoperazine, fluphenazine, imipramine, desmethylimipramine, nortriptyline and amitriptyline inhibited the accu...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136916
更新日期:1975-01-01 00:00:00
abstract::The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136819
更新日期:1978-01-01 00:00:00
abstract::The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137441
更新日期:1980-01-01 00:00:00
abstract::Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000075548
更新日期:2004-04-01 00:00:00
abstract::The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decr...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136585
更新日期:1976-01-01 00:00:00
abstract::Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137228
更新日期:1979-01-01 00:00:00
abstract::Gene knockout mice have proven to be very useful in understanding the role of xenobiotic-metabolizing enzymes in chemical toxicity and carcinogenesis. The combination of gene knockout technology with transgenic mouse technology should provide more versatile and suitable animal models to study the risks of chemical exp...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000028395
更新日期:2000-09-01 00:00:00
abstract::Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000448247
更新日期:2017-01-01 00:00:00
abstract::In an experimental model of haemorrhagic shock that causes 100% mortality in rats within 30 min, the intravenous bolus injection (20 micrograms/kg) of sulfated cholecystokinin octapeptide (CCK-8) induces a prompt and sustained rise in blood pressure and pulse amplitude, all treated animals still surviving at the end o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138480
更新日期:1988-01-01 00:00:00
abstract::Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139312
更新日期:1995-06-01 00:00:00
abstract::Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000241723
更新日期:2009-01-01 00:00:00
abstract::delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136851
更新日期:1978-01-01 00:00:00
abstract::Opioid antagonists have been shown to prevent the occurrence of lethal arrhythmias following coronary reperfusion. In this study, we have examined the effect of a new, long-lasting, potent opioid antagonist, nalmefene, and congeners in the prevention of reperfusion arrhythmias in dogs. Nalmefene given at a dose of 1 m...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138713
更新日期:1990-01-01 00:00:00
abstract::The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000346268
更新日期:2013-01-01 00:00:00
abstract::Hamster renal cytosol binds [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with high specificity. Sucrose density gradient centrifugation revealed two binding entities- one with a low sedimentation coefficient of 4-5 S which was displaced by neither TCDD nor other polycyclic aromatic hydrocarbons (PAHs) and another w...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138074
更新日期:1985-01-01 00:00:00
abstract::Effects of bepridil on the low voltage-activated T-type Ca2+ channel (CaV3.2) current stably expressed in human embryonic kidney (HEK)-293 cells were examined using patch-clamp techniques. Bepridil potently inhibited ICa,T with a markedly voltage-dependent manner; the IC50 of bepridil was 0.4 micromol/l at the holding...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000085329
更新日期:2005-07-01 00:00:00
abstract::To elucidate potential stereoselective effects of single barbiturate isomers, we compared the inhibitory potency of single thiopentone enantiomers, two isomer-enriched mixtures of methohexitone and racemic mixtures of both barbiturates on the fMLP-induced neutrophil oxidative response. A suppression of the response to...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000078627
更新日期:2004-09-01 00:00:00
abstract::A comparison was made of the anti-ischemic effects of dihydropyridine calcium antagonists in isolated globally ischemic rat hearts. Pretreatment with amlodipine, nifedipine, nitredipine, or nisoldipine reduced reperfusion enzyme (lactate dehydrogenase) release and contracture after 25 min of global ischemia and 30 min...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138652
更新日期:1990-01-01 00:00:00
abstract::The calcium channel antagonist, nifedipine (0.1 microM), only slightly inhibited the response to the full alpha 1-adrenoceptor agonist, (-)-norepinephrine, in rat aorta, but nearly completely inhibited the response to the partial alpha 1-adrenoceptor agonist, (-)-dobutamine, indicating that (-)-norepinephrine primaril...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138906
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000346737
更新日期:2013-01-01 00:00:00
abstract::The purpose of these studies was to evaluate the effects of the peptidoleukotriene (LT) receptor antagonist, ICI 198615, on the vasopressor responses produced by LTC4, LTD4 and LTE4. Conscious, normotensive rats were prepared with arterial and venous catheters for measurement of changes in arterial blood pressure and ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138699
更新日期:1990-01-01 00:00:00
abstract::The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating exposure to a FiO2 of 0.08, a FiCO2 of 0.035 and a FiN2 of 0.885, i.e. durin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139121
更新日期:1993-12-01 00:00:00
abstract::Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000364781
更新日期:2014-01-01 00:00:00
abstract::The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136830
更新日期:1978-01-01 00:00:00
abstract::When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138874
更新日期:1992-01-01 00:00:00
abstract::High-affinity (104 +/- 18 pmol/l) and high-density (204 +/- 25 fmol/mg) angiotensin II (AII) binding sites have been identified in Xenopus laevis heart membranes. Competition binding of [125I]Sar1,Ile8 angiotensin (SIA) to these receptors by peptide analogs selective for the mammalian AII receptor subtypes AT1 and AT2...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139186
更新日期:1994-04-01 00:00:00
abstract::Tramadol, a central analgesic acting on serotonin neurotransmission, is often co-used with ondansetron, a 5-HT(3) antagonist, for the management of postoperative pain to decrease nausea and vomiting. The aim of the study is to test the hypothesis that this drug combination raises tramadol requirement by patient-contro...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000330740
更新日期:2011-01-01 00:00:00
abstract::The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136728
更新日期:1977-01-01 00:00:00