Abstract:
:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculated: 6.72, and 7.75, respectively. Slopes of log (DR-1) against log (B) were not significantly different from unity. Histamine-induced acid secretion was not inhibited by atropine. Acid secretory response to acetylcholine was not reduced by concentrations of cimetidine up to 10(-3) mol/l. Acetylcholine-induced acid secretion was not influenced by hexamethonium. In the mouse isolated stomach, acetylcholine stimulates acid secretion through a direct cholinergic pathway.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Szelenyi I,Vergin Hdoi
10.1159/000137441subject
Has Abstractpub_date
1980-01-01 00:00:00pages
268-76issue
4eissn
0031-7012issn
1423-0313journal_volume
21pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Verapamil-induced cardiovascular depression has been examined in dial-urethane-anesthetized open chest dogs. Verapamil was administered slowly intravenously until the mean arterial pressure was decreased by approximately 45 mm Hg. The dose of verapamil required to reach the hemodynamic endpoint was 1,495 +/- (SE) 165 ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138317
更新日期:1987-01-01 00:00:00
abstract::A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137923
更新日期:1983-01-01 00:00:00
abstract::Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000445213
更新日期:2016-01-01 00:00:00
abstract::The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138460
更新日期:1988-01-01 00:00:00
abstract::The effects of a 1- or 24-hour pretreatment regimen with monophosphoryl lipid A (MLA, 35 micrograms/kg i.v.) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital-anesthetized dogs. Regional segment function (%SS) and myocardial blood flow were measured by sonomicrometry and the ra...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139329
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000110555
更新日期:2008-01-01 00:00:00
abstract::In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the vi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137385
更新日期:1980-01-01 00:00:00
abstract::DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137250
更新日期:1979-01-01 00:00:00
abstract::The present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (CBS) with thiols. Studies were performed using the monothiol glutathione (GSH), the dithiol dithiothreitol (DTT) and the thiol enzymes papain and H+/K(+)-ATPase. UV-vis spectra showed that CBS forms complexes with GSH and D...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139088
更新日期:1993-08-01 00:00:00
abstract::Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056110
更新日期:2001-07-01 00:00:00
abstract::The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000138507
更新日期:1988-01-01 00:00:00
abstract::In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preser...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000076259
更新日期:2004-05-01 00:00:00
abstract::Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000504758
更新日期:2020-01-01 00:00:00
abstract::The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056148
更新日期:2002-01-01 00:00:00
abstract::Tetraethylammonium chloride (TEA) at concentrations over 10(-3) mol/l produced a concentration-dependent contraction in the isolated canine coronary artery. We investigated mechanisms of the contractile response and the effects of various vasodilators on the contraction. While phentolamine, propranolol, guanethidine, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138224
更新日期:1986-01-01 00:00:00
abstract::Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137327
更新日期:1979-01-01 00:00:00
abstract::The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137947
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000235997
更新日期:2009-01-01 00:00:00
abstract::The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10(-6) M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by si...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138088
更新日期:1985-01-01 00:00:00
abstract::The influence of hyperthyroidism on the functional vascular responsiveness of isolated coronary and renal resistance vessels was investigated. Hyperthyroidism was established by feeding rats for 1 and 4 weeks with 5 mg/kg L-thyroxine (T4)-containing rat chow. Preparations of either coronary or renal resistance vessels...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139519
更新日期:1997-09-01 00:00:00
abstract::Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000444188
更新日期:2016-01-01 00:00:00
abstract::The purpose of this investigation on human umbilical arteries was: (1) to analyze the effects of magnesium (Mg2+) in the prevention of contractions induced by 5-hydroxytryptamine (5-HT), KCl, Bay K 8644 and BaCl2; (2) to determine whether the presence of Mg2+ could modulate the response to caffeine in Ca2+-free medium...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028255
更新日期:1998-12-01 00:00:00
abstract::Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137991
更新日期:1984-01-01 00:00:00
abstract::Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137813
更新日期:1983-01-01 00:00:00
abstract::The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137508
更新日期:1981-01-01 00:00:00
abstract::Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000093790
更新日期:2006-01-01 00:00:00
abstract::The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, wa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137367
更新日期:1980-01-01 00:00:00
abstract::The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138804
更新日期:1991-01-01 00:00:00
abstract:AIM:This study investigates factors influencing the severity of opiate withdrawal symptoms, focusing on the relationship between methadone dose and withdrawal severity among opiate-dependent in-patients receiving methadone detoxification. METHODS:The sample comprised 48 opiate-dependent patients admitted to a speciali...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000109982
更新日期:2008-01-01 00:00:00
abstract::L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxif...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139026
更新日期:1993-01-01 00:00:00