Enhanced pressor responses to angiotensin II caused by excessive sodium loading in the pithed rat.

abstract：:This study was designed to document possible changes in the binding of bupivacaine (BV), lidocaine (LC) and their main metabolites desbutylbupivacaine (PPX) and monoethylglycinexylydide (MEGX), respectively, to plasma proteins and erythrocytes in mice after acute treatment with the calcium antagonists diltiazem (DZ), ...

journal_title：Pharmacology

authors： Jacob D,Grignon S,Attolini L,Gantenbein M,Bruguerolle B

更新日期：1996-10-01 00:00:00

abstract：:Interferons are known to prevent liver collagen by an antifibrogenic mechanism that involves mRNA procollagen regulation. The aim of the present work was to determine whether interferon could also decrease collagen by increasing its degradation. Fibrosis was induced in male Wistar rats by double ligation and section o...

journal_title：Pharmacology

authors： Rodríguez-Fragoso L,González MP,Muriel P

更新日期：1995-12-01 00:00:00

abstract：:Opioid antagonists have been shown to prevent the occurrence of lethal arrhythmias following coronary reperfusion. In this study, we have examined the effect of a new, long-lasting, potent opioid antagonist, nalmefene, and congeners in the prevention of reperfusion arrhythmias in dogs. Nalmefene given at a dose of 1 m...

journal_title：Pharmacology

authors： Caldwell RW,Nagarajan R,Chryssanthis A,Tuttle RR

更新日期：1990-01-01 00:00:00

abstract：:In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...

journal_title：Pharmacology

authors： Sivaramakrishna N,Gulati OD

更新日期：1975-01-01 00:00:00

abstract：:We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intrave...

journal_title：Pharmacology

authors： Abe Y,Watanabe K,Sato S,Nagai Y,Kamal FA,Wahed MI,Wen J,Narasimman G,Ma M,Suresh P,Takahashi T,Tachikawa H,Kashimura T,Tanabe N,Kodama M,Aizawa Y,Yamaguchi K,Miyazaki M,Kakemi M

更新日期：2004-12-01 00:00:00

abstract：:Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...

journal_title：Pharmacology

authors： Colby HD,Nowak DM,Longhurst PA,Zhang X,Hayes JR,Voigt JM

更新日期：2001-05-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...

journal_title：Pharmacology

authors： Yang YP,Zhu ML,Zhang HY,Song P,Xu J,Li P,Yin YL

更新日期：2020-01-01 00:00:00

abstract：:In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the vi...

journal_title：Pharmacology

authors： Kandasamy SB

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...

journal_title：Pharmacology

authors： Bruderer S,Marjason J,Sidharta PN,Dingemanse J

更新日期：2013-01-01 00:00:00

abstract：:The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...

journal_title：Pharmacology

authors： Del Soldato P,Ghiorzi A,Cereda E,Donetti A

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:The haemodynamic changes during epidural anaesthesia and following the administration of dihydroergotamine (DHE; 10 micrograms/kg i.v.) were studied in 7 dogs (epidural group). Epidural anaesthesia was associated with reductions in mean arterial, mean pulmonary arterial and mean right atrial pressures. Femoral flow wa...

journal_title：Pharmacology

authors： Zimpfer M,Schwarz M,Stanek B,Raberger G

更新日期：1981-01-01 00:00:00

abstract：AIMS:To compare the bioavailability of a new oromucosal formulation of flurbiprofen 8.75-mg lozenges, developed by Alfa Wassermann S.p.A. (test drug) to that of marketed flurbiprofen 8.75-mg lozenges (Benactiv Gola®, reference drug). METHODS:This was an open, randomised, two-period, crossover, pharmacokinetic (PK) stu...

journal_title：Pharmacology

authors： Matzneller P,Burian A,Martin W,Annoni O,Lauro V,Tacchi R,Brunner M,Zeitlinger M

更新日期：2012-01-01 00:00:00

abstract：:Three doses (0.31, 3.1 and 31 mg/kg) of methotrexate (MTX) were given intravenously to rats. The resulting concentration-time curves in plasma (normalized by dividing the plasma concentration by a multiple of the dose) were not superimposable, indicating nonlinear plasma pharmacokinetics. In liver, kidney, bone marrow...

journal_title：Pharmacology

authors： Scheufler E

更新日期：1982-01-01 00:00:00

abstract：:The affinity of amitriptyline for muscarine M1 receptors was studied in the rat cerebral cortex and rabbit vas deferens utilizing binding studies as well as inhibition of carbachol-induced phosphoinositide hydrolysis in the cerebral cortex and blockade of the muscarinic prejunctional inhibition of sympathetic nerve st...

journal_title：Pharmacology

authors： Choi A,Mitchelson F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

journal_title：Pharmacology

authors： Noorbakhshnia M,Rahmani-Samani P,Eivani M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-alpha is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha in free-feeding rats. METHODS:Three groups of male Wista...

journal_title：Pharmacology

authors： Trapali M,Liapi C,Perelas A,Perrea D,Stroubini T,Dontas I,Couvari E,Mavri M,Galanopoulou P

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:The neurotransmitters participating in the nerve-mediated contraction of the guinea pig seminal vesicle (GPSV) have not been firmly established. There is debate as to the mediating role of norepinephrine and acetylcholine. METHODS:We have used longitudinally and circularly oriented strips of GPSV and a...

journal_title：Pharmacology

authors： Benko R,Szombati V,Bartho L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

journal_title：Pharmacology

authors： Dan K,Katoh N,Matsuoka T,Fujinami K

更新日期：2019-06-06 00:00:00

abstract：:The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...

journal_title：Pharmacology

authors： Abalo R,Vera G,López-Pérez AE,Martínez-Villaluenga M,Martín-Fontelles MI

更新日期：2012-01-01 00:00:00

abstract：:The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...

journal_title：Pharmacology

authors： Noguchi K,Kase J,Saitoh M,Masumiya H,Saitoh M,Nakazawa T,Tanaka Y,Tanaka H,Hashimoto K,Shigenobu K

更新日期：2002-01-01 00:00:00

abstract：:The effect of delta-sleep-inducing peptide (DSIP) on the anticonvulsive activity of a nonprotective valproate (VPA) dose in a metaphit model of generalized, reflex audiogenic seizures in adult Wistar rats was studied. The animals that received metaphit (10 mg/kg) were exposed to audiogenic stimulation (100 +/- 3 dB, 6...

journal_title：Pharmacology

authors： Hrncić D,Stanojlović O,Zivanović D,Susić V

更新日期：2006-01-01 00:00:00

abstract：:Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...

journal_title：Pharmacology

authors： Ai J,Wang X,Nielsen M

更新日期：2001-07-01 00:00:00

abstract：:The effect of beta-adrenoceptor antagonists on the receptor-mediated low density lipoprotein (LDL) binding and internalization was studied in vitro in human skin fibroblasts. The cellular uptake of 125I-labeled human LDL was dose dependently elevated by some, but not all, of the drugs used. This effect of beta-adrenoc...

journal_title：Pharmacology

authors： Bernini F,Corsini A,Allorio M,Musanti R,Fumagalli R

更新日期：1987-01-01 00:00:00

abstract：:The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment. Luminal sodium rhein (1 mM) produced a protracted increase in cae...

journal_title：Pharmacology

authors： Rumsey RD,Squires PE,Read NW

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...

journal_title：Pharmacology

authors： Castellão-Santana LM,Yumi Abiko P,Ambiel CR,Peixoto AR,Noronha-Matos JB,Correia-de-Sá P,Alves-Do-Prado W

更新日期：2019-01-01 00:00:00

abstract：:The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...

journal_title：Pharmacology

authors： Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

更新日期：2000-01-01 00:00:00

abstract：:A comparison was made of the anti-ischemic effects of dihydropyridine calcium antagonists in isolated globally ischemic rat hearts. Pretreatment with amlodipine, nifedipine, nitredipine, or nisoldipine reduced reperfusion enzyme (lactate dehydrogenase) release and contracture after 25 min of global ischemia and 30 min...

journal_title：Pharmacology

authors： Grover GJ,Dzwonczyk S,Sleph PG

更新日期：1990-01-01 00:00:00

abstract：:Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of metabolism. The present studies were done to determine the basis for this distribution. Among the enzyma...

journal_title：Pharmacology

authors： Colby HD,Huang Y,Jiang Q,Voigt JM

更新日期：2000-08-01 00:00:00