Abstract:
:Interferons are known to prevent liver collagen by an antifibrogenic mechanism that involves mRNA procollagen regulation. The aim of the present work was to determine whether interferon could also decrease collagen by increasing its degradation. Fibrosis was induced in male Wistar rats by double ligation and section of the common bile duct. Interferon-alpha 2b (100,000 IU/rat s.c.) was administered to bile duct ligated rats daily after surgery for 4 weeks. Interferon increased the capacity of the liver to degrade type I and III collagens and matrigel. In addition, the plasminogen activator activity also increased. Since plasminogens are thought to be key participants in the balance of proteolytic activities that regulate extracellular matrix degradation, their elevation may also provide another antifibrotic (proteolytic) mechanism of action of interferon.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Rodríguez-Fragoso L,González MP,Muriel Pdoi
10.1159/000139345subject
Has Abstractpub_date
1995-12-01 00:00:00pages
341-6issue
6eissn
0031-7012issn
1423-0313journal_volume
51pub_type
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