Abstract:
OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for 6 weeks. The primary efficacy measurement was the change of the 17-item Hamilton Depression Rating Scale (HAMD-17) total score from baseline to the end of the study. The secondary efficacy measurements were the response and remission rates, the Clinical Global Impression - Improvement of Illness (CGI-I) score at the end of the study, and the change of the HAMD-14 total score and quality of sleep [evaluated by the Pittsburgh Sleep Quality Index (PSQI) scale] during the study period. RESULTS:The mean maximum daily dose was 273.11 mg for the trazodone group and 290.92 mg for the placebo group. At the end of the study, there was a significant difference between the two groups in the HAMD-17 change score (trazodone vs. placebo: -11.07 vs. -8.29, p < 0.001). Trazodone showed advantages at 1 week of treatment, and the effect lasted until the end of the study (week 6). The response and remission rates of the trazodone group were significantly higher than those in the placebo group (response rate: 59.6 vs. 37.2%, p < 0.001; remission rate: 35.5 vs. 22.2%, p = 0.005). The majority of the adverse reactions of trazodone were mild to moderate, and the most frequent adverse reactions (≥5%) were dizziness, dry mouth, somnolence, and nausea. CONCLUSIONS:Prolonged-release trazodone was more effective than placebo in MDD and was well tolerated.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Zhang L,Xie WW,Li LH,Zhang HG,Wang G,Chen DC,Cao Y,Cui LJ,Zhang KR,Shi JG,Tan QR,Zheng HB,Xu XF,Cheng ZH,Zhao JPdoi
10.1159/000368559subject
Has Abstractpub_date
2014-01-01 00:00:00pages
199-206issue
5-6eissn
0031-7012issn
1423-0313pii
000368559journal_volume
94pub_type
杂志文章,多中心研究,随机对照试验相关文献
PHARMACOLOGY文献大全abstract::Imatinib and AMN107 are protein tyrosine kinase inhibitors which reduce KIT autophosphorylation with similar potency. This report describes the cellular uptake of these compounds in two human gastrointestinal stromal tumor (GIST)-derived cell lines (GIST882 and GIST GDG1), which both express constitutively activated K...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091943
更新日期:2006-01-01 00:00:00
abstract::Veratridine caused a positive inotropic action in the electrically driven left atria of rats. Quinacrine (a phospholipase A2 inhibitor), indomethacin (a cyclooxygenase inhibitor) and aspirin (a cyclooxygenase inhibitor), but not nordihydroguaiaretic acid (a lipoxygenase inhibitor), inhibited the response to veratridin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138774
更新日期:1991-01-01 00:00:00
abstract::Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056100
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND/AIMS:We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. METHODS:Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (5...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000316113
更新日期:2010-01-01 00:00:00
abstract::The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138585
更新日期:1989-01-01 00:00:00
abstract:AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...
journal_title:Pharmacology
pub_type: 杂志文章,meta分析
doi:10.1159/000149569
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000505297
更新日期:2020-01-01 00:00:00
abstract::Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028197
更新日期:1998-04-01 00:00:00
abstract::Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139413
更新日期:1996-07-01 00:00:00
abstract::Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137327
更新日期:1979-01-01 00:00:00
abstract::Serotonin-depleting lesions of midbrain raphe (extensive lesions located within dorsal and partly median raphe muclei) induced intraspecific agressiveness in grouped Wistar male rats but failed to increase mouse-killing behaviour. Rats which had lesions in the lateral midbrain did not display intraspecific aggression ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136887
更新日期:1975-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates lipid metabolism. Recently, PPARgamma was reported to be a negative regulator in the immune system. Eosinophils also express PPARgamma, however, the role of PPARgamma in eosinophil functions is not well understood. Surfac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000085034
更新日期:2005-07-01 00:00:00
abstract::Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488083
更新日期:2018-01-01 00:00:00
abstract::The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, wa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137367
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000343634
更新日期:2013-01-01 00:00:00
abstract::Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000093790
更新日期:2006-01-01 00:00:00
abstract::As a major Ca(2+) source for muscle contraction, the sarcoplasmic reticulum (SR) of skeletal muscle maintains its Ca(2+) content by uptake of myoplasmic Ca(2+) and by replenishment with extracellular Ca(2+). Since transection of motor nerve alters the functions of SR Ca(2+) pump and sarcolemma ion channels, this study...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000082755
更新日期:2005-03-01 00:00:00
abstract::Wood creosote has long been used as an antidiarrheal agent, but its mechanism of action is not well understood. To elucidate the mechanism of its antidiarrheal activity, we have addressed questions whether it inhibits fluid secretion induced by Escherichia coli heat-stable enterotoxin (STa) in rabbit jejunum in vivo, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056092
更新日期:2001-01-01 00:00:00
abstract::We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intrave...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000080375
更新日期:2004-12-01 00:00:00
abstract::The effect and mechanism of action of serotonin (5-HT) were studied in the pulmonary circulation of normal and diabetic rabbits. 5-HT (10, 50 and 100 nmol/l) produced a concentration-dependent increase in rabbit pulmonary arterial tension. Pulmonary arterial rings from diabetic rabbits were more responsive to 5-HT com...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139426
更新日期:1996-09-01 00:00:00
abstract::The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000082804
更新日期:2005-03-01 00:00:00
abstract:AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335491
更新日期:2012-01-01 00:00:00
abstract::Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137758
更新日期:1982-01-01 00:00:00
abstract::The effects of several paired analogs of angiotensin II and angiotensin III, designed as antagonists, have been compared in isolated smooth muscle (rat uterus) and by in vivo rat blood pressure assay. These analogs were (1) the angiotensin II series: (1-sarcosine, 7-X, 8-isoleucine-) angiotensin II, and (2) the angiot...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137342
更新日期:1980-01-01 00:00:00
abstract::The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138807
更新日期:1991-01-01 00:00:00
abstract::The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136874
更新日期:1978-01-01 00:00:00
abstract::Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000075548
更新日期:2004-04-01 00:00:00
abstract::Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000138153
更新日期:1986-01-01 00:00:00
abstract::Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138878
更新日期:1992-01-01 00:00:00
abstract:AIM:This study investigates factors influencing the severity of opiate withdrawal symptoms, focusing on the relationship between methadone dose and withdrawal severity among opiate-dependent in-patients receiving methadone detoxification. METHODS:The sample comprised 48 opiate-dependent patients admitted to a speciali...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000109982
更新日期:2008-01-01 00:00:00