Abstract：
BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days, the mice were sacrificed. Wet dry weight (W/D) ratio of lung was used to detect pulmonary edema. Myeloperoxidase (MPO), interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) were detected by enzyme-linked immunosorbent assay. Hematoxylin and eosin staining was used to evaluate the pathological changes. The levels of transforming growth factor β (TGF-β), phosphorylated-smad3 (p-smad3), p-IκB, and p-nuclear factor-kappa B (NF-κB) in lung tissue were detected by western blot. RESULTS:GAA treatment significantly improved MPO activity, W/D ratio, and lung histopathology. The protective effect of GAA may be related to downregulation of TNF-α, IL-1β, IL-6, MDA and upregulation of SOD. In addition, GAA significantly decreased the levels of TGF-β, p-smad3, p-IκB, and p-NF-κB, compared with those in BLM group. CONCLUSION:GAA has protective effect on BLM-induced lung injury, and TGF-β/Smad-3/NF-κB signaling pathway may play an important role in the pathogenesis of BLM-induced lung injury.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Wen G,Li T,He H,Zhou X,Zhu Jdoi
10.1159/000505297subject
Has Abstractpub_date
2020-01-01 00:00:00pages
568-575issue
9-10eissn
0031-7012issn
1423-0313pii
000505297journal_volume
105pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract：:The effect of beta-adrenoceptor antagonists on the receptor-mediated low density lipoprotein (LDL) binding and internalization was studied in vitro in human skin fibroblasts. The cellular uptake of 125I-labeled human LDL was dose dependently elevated by some, but not all, of the drugs used. This effect of beta-adrenoc...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138272
更新日期：1987-01-01 00:00:00
abstract：:Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000445213
更新日期：2016-01-01 00:00:00
abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000028197
更新日期：1998-04-01 00:00:00
abstract：:We investigated the antihypertensive effect of 5-HT1A agonist (buspirone) and 5-HT2B antagonists (SB204741 and SB200646) in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats. Experiments were divided into two sets: in the first set, sham-operated control and DOCA-treated hypertensive rats received busp...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000082114
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000351704
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...
journal_title：Pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000343634
更新日期：2013-01-01 00:00:00
abstract：:Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000135848
更新日期：1977-01-01 00:00:00
abstract：:We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000094900
更新日期：2006-01-01 00:00:00
abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000328411
更新日期：2011-01-01 00:00:00
abstract：:This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five gro...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000139492
更新日期：1997-05-01 00:00:00
abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138300
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND/AIMS:morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. METHODS:cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electr...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000316637
更新日期：2010-01-01 00:00:00
abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000148260
更新日期：2008-01-01 00:00:00
abstract：:The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138107
更新日期：1985-01-01 00:00:00
abstract：:A rapid and sensitive gas chromatographic method for the determination of the beta-adrenergic agent isoxsuprine in human plasma has been developed. The procedure involves the extraction of the drug with ether and an internal standard (propranolol) from plasma at alkaline pH, solvent evaporation, and the formation of a...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000137843
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND/AIMS:Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. METHODS:Administration of a potent cannabinoid ag...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000335368
更新日期：2012-01-01 00:00:00
abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000071266
更新日期：2003-09-01 00:00:00
abstract：:Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138861
更新日期：1991-01-01 00:00:00
abstract：:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000137441
更新日期：1980-01-01 00:00:00
abstract：:We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally 10 and 30 min prior to ischemic i...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000139245
更新日期：1994-11-01 00:00:00
abstract：:Wood creosote, a mixture of phenolic compounds, suppresses in vitro contractions of rat intestine. To identify a compound in wood creosote able to inhibit intestinal motility, we screened its constituent phenolic compounds and found 4-ethylguaiacol (4-EG) as an active compound. It suppressed the spontaneous phasic (IC...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000139111
更新日期：1993-11-01 00:00:00
abstract：:The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...
journal_title：Pharmacology
pub_type： 杂志文章,评审
doi：10.1159/000339072
更新日期：2012-01-01 00:00:00
abstract：:The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138049
更新日期：1985-01-01 00:00:00
abstract：:Vascular dementia (VaD) is the second most common type of dementia and has become a major public health challenge as the global population ages. VaD is caused by cerebrovascular disease, and most patients with VaD have been reported to also have Alzheimer's pathologies, which is the formation of neurofibrillary tangle...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000504056
更新日期：2020-01-01 00:00:00
abstract：:Topically unilaterally applied lisuride caused dose-related lowering of intraocular pressure in ipsilateral (treated) but not in contralateral eyes of normal rabbits. The ocular hypotensive response induced by lisuride was antagonized by pretreatment with metoclopramide, a dopamine receptor antagonist, and was partial...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000028249
更新日期：1998-11-01 00:00:00
abstract：:Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000056110
更新日期：2001-07-01 00:00:00
abstract：:The diastereomeric glucuronic acid conjugates are major metabolites of the nonsteroidal anti-inflammatory drug fenoprofen (FEN). Glucuronidation of FEN enantiomers was investigated with liver microsomal preparations from different species (sheep, rabbit, rat and human). The formed R- and S-FEN conjugates can be separa...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138828
更新日期：1991-01-01 00:00:00
abstract：:The dependence of intestinal absorption of xenobiotics on the blood flow rate increases from blood flow independent to blood flow limited absorption as the absorbability of the substances increases. Since the absorbed substances are mainly drained by the blood flowing through the subepithelial vessels, not only the to...
journal_title：Pharmacology
pub_type： 杂志文章,评审
doi：10.1159/000137409
更新日期：1980-01-01 00:00:00
abstract：:Feeding a thiamin-deficient diet to male and female rats for 3 weeks alters the mixed function oxidases responsible for metabolizing benzo(a)pyrene and enhances the response of these enzymes to induction by phenobarbital or 3-methylcholanthrene. The caloric restriction observed in thiamin deprivation may be partially ...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138004
更新日期：1984-01-01 00:00:00
abstract：:The effects of intravenous administration of adrenoceptor agonists and antagonists on electrocardiographic or blood pressure (BP) functional parameters were assessed in urethane-anesthetized rats. The responses of cardiovascular functional parameters produced by these drugs included: (1) isoproterenol decreased the du...
journal_title：Pharmacology
pub_type： 杂志文章
doi：10.1159/000138922
更新日期：1992-01-01 00:00:00
