Effects of adrenoceptor agonists and antagonists on cardiovascular functional parameters in rats.

abstract：:Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...

journal_title：Pharmacology

authors： Colby HD,Nowak DM,Longhurst PA,Zhang X,Hayes JR,Voigt JM

更新日期：2001-05-01 00:00:00

abstract：:The purpose of the study was to test the hypothesis that the postischemic neuronal damage is accompanied by changes of the electrocorticogram (ECoG) of freely moving rats during long-term recovery after forebrain ischemia. Ten minutes forebrain ischemia was induced in male Wistar rats. ECoG was recorded 1 day before a...

journal_title：Pharmacology

authors： Peruche B,Klaassens H,Krieglstein J

更新日期：1995-04-01 00:00:00

abstract：AIMS:Recent studies have reported that intracellular calcium (Ca(2+)) mobilization is involved in homocysteine (Hcy)-induced endothelial dysfunction and the Na(+)/H(+) exchanger (NHE) is responsible for an increase in the intracellular Ca(2+) concentration in cardiovascular disease. We hypothesized that inhibition of t...

journal_title：Pharmacology

authors： Wu S,Gao X,Yang S,Liu L,Ge B,Yang Q

更新日期：2013-01-01 00:00:00

abstract：:We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...

journal_title：Pharmacology

authors： Lin HC,Cheng TH,Chen YC,Juan SH

更新日期：2004-06-01 00:00:00

abstract：:The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...

journal_title：Pharmacology

authors： Feldman S,Putcha L

更新日期：1977-01-01 00:00:00

abstract：:In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...

journal_title：Pharmacology

authors： Trivedi CJ,Balaraman R,Majithiya JB,Bothara SB

更新日期：2006-01-01 00:00:00

abstract：:Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that ca...

journal_title：Pharmacology

authors： Dai S,Ogle CW,Cho CH

更新日期：1986-01-01 00:00:00

abstract：:The cardiovascular effects of SKP-450, a newly synthesized potassium channel activator, and its two major metabolites SKP-818 and SKP-310 were evaluated on isolated rat aorta and in freely moving rats and anesthetized beagle dogs. The rank order of potency in relaxing rat aorta precontracted with norepinephrine was SK...

journal_title：Pharmacology

authors： Shin HS,Seo HW,Yoo SE,Lee BH

更新日期：1998-03-01 00:00:00

abstract：:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...

journal_title：Pharmacology

authors： Szelenyi I,Vergin H

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...

journal_title：Pharmacology

authors： Hanioka N,Tanaka S,Moriguchi Y,Narimatsu S

更新日期：2012-01-01 00:00:00

abstract：:Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...

journal_title：Pharmacology

authors： Ertunc M,Sara Y,Korkusuz P,Onur R

更新日期：2009-01-01 00:00:00

abstract：:Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...

journal_title：Pharmacology

authors： Schiller D,Maieron A,Schöfl R,Donnerer J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...

journal_title：Pharmacology

authors： Karamanakos PN,Pappas P,Boumba V,Vougiouklakis T,Marselos M

更新日期：2016-01-01 00:00:00

abstract：:The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decr...

journal_title：Pharmacology

authors： Posner P,Chiou CY

更新日期：1976-01-01 00:00:00

abstract：:Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...

journal_title：Pharmacology

authors： Mizrahi J,D'Orléans-Juste P,Caranikas S,Regoli D

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...

journal_title：Pharmacology

authors： Di Giusto G,Anzai N,Endou H,Torres AM

更新日期：2008-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...

journal_title：Pharmacology

authors： Chen X,Dong Y,Cao S,Li X,Wang Z,Chen R,Ge RS

更新日期：2016-01-01 00:00:00

abstract：:The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...

journal_title：Pharmacology

authors： Mitsos SE,Jolly SR,Lucchesi BR

更新日期：1985-01-01 00:00:00

abstract：:Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...

journal_title：Pharmacology

authors： Petermann M,Bravo M,Videla L,Ugarte G

更新日期：1979-01-01 00:00:00

abstract：:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...

journal_title：Pharmacology

authors： Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

更新日期：1987-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：:The affinity of amitriptyline for muscarine M1 receptors was studied in the rat cerebral cortex and rabbit vas deferens utilizing binding studies as well as inhibition of carbachol-induced phosphoinositide hydrolysis in the cerebral cortex and blockade of the muscarinic prejunctional inhibition of sympathetic nerve st...

journal_title：Pharmacology

authors： Choi A,Mitchelson F

更新日期：1994-05-01 00:00:00

abstract：:The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...

journal_title：Pharmacology

authors： Siddik ZH,Drew R,Litterst CL,Mimnaugh EG,Sikic BI,Gram TE

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...

journal_title：Pharmacology

authors： Wang T,Ge S,Xiong W,Zhou P,Cang J,Xue Z

更新日期：2013-01-01 00:00:00

abstract：:A multicenter, placebo-controlled, double-dummy, randomized, parallel-group, double-blind study was conducted to verify the hypothesis of noninferiority for single-dose administration of zaltoprofen 160 mg, a nonsteroidal anti-inflammatory drug, compared with loxoprofen sodium 60 mg (loxoprofen), in terms of antipyret...

journal_title：Pharmacology

authors： Azuma A,Kudoh S,Nakashima M,Nagatake T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...

journal_title：Pharmacology

authors： Dannenberg L,Trojovsky K,Ayhan A,Helten C,Zako S,M'Pembele R,Mourikis P,Benkhoff M,Ignatov D,Sarabhai T,Petzold T,Huhn-Wientgen R,Zeus T,Kelm M,Levkau B,Polzin A

更新日期：2020-11-20 00:00:00

abstract：:The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...

journal_title：Pharmacology

authors： Knape JT,van Zwieten PA

更新日期：1988-01-01 00:00:00

abstract：:Angiotensin II (ANG II) is a potent vasoconstrictor in most vascular beds. We studied the role of cyclooxygenase products and/or endothelium-derived relaxing factor (EDRF) in modulating the pressor response to ANG II in the isolated, blood perfused dog lung. ANG II was given as a bolus dose of 2, 4 and 8 micrograms be...

journal_title：Pharmacology

authors： el-Kashef HA,Ehrhart IC,Hofman WF

更新日期：1990-01-01 00:00:00