Abstract:
:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic brain syndrome. In only 4 could the narcotic dose be decreased without exacerbating the pain. Eleven patients had mental status impairment associated with factors other than the narcotic dose. These factors were: concurrent CNS-depressant drugs, presence of fever or infection, or changing from parental to average oral equianalgesic dose of narcotic. When these factors were corrected, mental function improved and remained stable despite resumption of the previous narcotic dose. Delirium occurred more frequently in patients over 65, while oversedation without delirium was more frequent in the younger group. For some patients with advanced metastatic cancer, pain relief and intact mental status cannot coexist. For others, correction of factors other than narcotics which can impair function can often lead to improved mental status without decreasing narcotic dose or decreasing the degree of pain control.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MMdoi
10.1159/000138294subject
Has Abstractpub_date
1987-01-01 00:00:00pages
47-54issue
1eissn
0031-7012issn
1423-0313journal_volume
35pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094521
更新日期:2006-01-01 00:00:00
abstract::In this study, we used a novel conscious dog model to evaluate the uroselectivity of selected alpha 1-antagonists either approved for human use or in clinical development for the treatment of symptomatic benign prostatic hyperplasia (BPH) and compared those results to their in vitro binding and functional affinities a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139451
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000500314
更新日期:2019-01-01 00:00:00
abstract:AIMS:Recent studies have reported that intracellular calcium (Ca(2+)) mobilization is involved in homocysteine (Hcy)-induced endothelial dysfunction and the Na(+)/H(+) exchanger (NHE) is responsible for an increase in the intracellular Ca(2+) concentration in cardiovascular disease. We hypothesized that inhibition of t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000356318
更新日期:2013-01-01 00:00:00
abstract::The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non-peptide tachykinin receptor antagonists, were examined and compared to those of FK-888 and GR-159897. Since no functional NK(3) receptors were found in the rat bladder, the emphasis will be on the...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056193
更新日期:2002-05-01 00:00:00
abstract:AIM:An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS:Forty-five patients with hypercholesterolemia and as...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000276476
更新日期:2010-01-01 00:00:00
abstract::Wood creosote, a mixture of phenolic compounds, suppresses in vitro contractions of rat intestine. To identify a compound in wood creosote able to inhibit intestinal motility, we screened its constituent phenolic compounds and found 4-ethylguaiacol (4-EG) as an active compound. It suppressed the spontaneous phasic (IC...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139111
更新日期:1993-11-01 00:00:00
abstract::The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136728
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000351704
更新日期:2013-01-01 00:00:00
abstract::The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000346268
更新日期:2013-01-01 00:00:00
abstract::Regional cerebral metabolic rates of glucose (rCMRglu) were measured in conscious rats grouped according to three treatments: control, bicuculline (5.5 mg/kg s.c.), and intracerebroventricular arginine vasopressin (0.5 micrograms/5 microliter). Rats in the latter group were pre-exposed to the peptide 48 h earlier to r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138340
更新日期:1988-01-01 00:00:00
abstract::The pregnane X receptor (PXR/NR1I2) gene is a master regulator for a number of cytochrome P450s (CYPs) and drug transporters. This study aimed to detect the single nucleotide polymorphisms (SNPs) of the PXR gene in Han Chinese (n = 186) and to compare the frequencies of polymorphisms of the PXR gene with those in Cauc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000123687
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000235997
更新日期:2009-01-01 00:00:00
abstract::The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138300
更新日期:1987-01-01 00:00:00
abstract::Effects of schisandrin B enantiomer ((+)Sch B and (-)Sch B) treatment on the reduced cellular glutathione (GSH) level and susceptibility to menadione-induced toxicity were investigated and compared in AML12 hepatocytes. (+)Sch B or (-)Sch B treatment at 6.25 micromol/l produced a time-dependent change in cellular GSH ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000092773
更新日期:2006-01-01 00:00:00
abstract::Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-mescaline in the pellet. 1.33 mumol/ml of chlorpromazine, trifluoperazine, fluphenazine, imipramine, desmethylimipramine, nortriptyline and amitriptyline inhibited the accu...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136916
更新日期:1975-01-01 00:00:00
abstract::Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When N...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000067801
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Although it is beneficial to protect the skin from natural aging, especially in an aging society, the approach by which this can be achieved is still not well known. Hochu-ekki-to, a Chinese natural medicine, has various advantageous effects; however, there is no report about its influence on skin aging. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000504985
更新日期:2020-01-01 00:00:00
abstract::The ovariectomized (OVX) rat, as an established animal model of human osteoporosis, was adopted in the present experiment to study the protective effects of sodium daidzein sulfonate (SDS) on trabecular bone. Six-month-old Sprague-Dawley rats were sham-operated or ovariectomized. Five days later, the OVX rats were ran...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000098115
更新日期:2007-01-01 00:00:00
abstract::Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000075548
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000110555
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. METHODS:In this study, we assessed stabilities in rat and human microsomes of 121 com...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000343241
更新日期:2012-01-01 00:00:00
abstract::Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups according to polarity and molecular size o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139852
更新日期:1993-10-01 00:00:00
abstract::Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure liquid chromatographic assay method. Comparison with newly synthesized,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137594
更新日期:1982-01-01 00:00:00
abstract::The type-1 cannabinoid receptor (CB1R) was initially identified as the neuronal target of Δ(9)-tetrahydrocannabinol (THC), the major psychoactive substance of marijuana. This receptor is one of the most abundant G-protein-coupled receptors in the adult brain, the target of endocannabinoid ligands and a well-characteri...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339075
更新日期:2012-01-01 00:00:00
abstract:AIM:This study investigates factors influencing the severity of opiate withdrawal symptoms, focusing on the relationship between methadone dose and withdrawal severity among opiate-dependent in-patients receiving methadone detoxification. METHODS:The sample comprised 48 opiate-dependent patients admitted to a speciali...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000109982
更新日期:2008-01-01 00:00:00
abstract::The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138522
更新日期:1989-01-01 00:00:00
abstract::Wood creosote has long been used as an antidiarrheal agent, but its mechanism of action is not well understood. To elucidate the mechanism of its antidiarrheal activity, we have addressed questions whether it inhibits fluid secretion induced by Escherichia coli heat-stable enterotoxin (STa) in rabbit jejunum in vivo, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056092
更新日期:2001-01-01 00:00:00
abstract::The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138451
更新日期:1988-01-01 00:00:00
abstract::Both acute and chronic oral administration (1-20 mg/kg) of FCE 22716, a new ergoline derivative, resulted in a dose-related fall of arterial blood pressure lasting for more than 6 h. Tachycardia was observed only at high dosages. Yohimbine, propranolol and indometacin did not modify its antihypertensive effect; on the...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138523
更新日期:1989-01-01 00:00:00