Abstract:
:The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had a direct dilatory effect on large coronary arteries in situ and it attenuated the vasoconstriction induced by vasopressin. It shifted the dose-response curve of vasopressin to the right in a noncompetitive manner. Nisoldipine reduced the effect of vasopressin on maximum left ventricular dP/dt, mean aortic pressure, left ventricular end-systolic pressure and heart rate. The results demonstrate that nisoldipine is an effective dilator of large epicardial coronary arteries in situ and inhibits the vasoconstriction induced by vasopressin.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Saito T,Saeed M,Bing RJdoi
10.1159/000138451subject
Has Abstractpub_date
1988-01-01 00:00:00pages
85-93issue
2eissn
0031-7012issn
1423-0313journal_volume
37pub_type
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