Abstract:
:A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the preparation. This preparation also contained minute amount of immunoreactive and biologically active ACTH.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Iida S,Itoh Y,Moriwaki Kdoi
10.1159/000137598subject
Has Abstractpub_date
1982-01-01 00:00:00pages
211-4issue
4eissn
0031-7012issn
1423-0313journal_volume
24pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056110
更新日期:2001-07-01 00:00:00
abstract::43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days. Both drugs produced an improvement in subjective symptoms by day 7, although the most rapid analgesic effect was obtained with suprofen. Patients receiving suprofen experienced a signi...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137898
更新日期:1983-01-01 00:00:00
abstract::86Rb efflux assay was used to investigate the effect of cromakalim, pinacidil and P1075 in guinea pig urinary bladder strips. The type of K channel opened by cromakalim and pinacidil was determined using specific K channel blockers through 86Rb efflux assay in detrusor strips. Cromakalim, pinacidil and P1075 all three...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139230
更新日期:1994-09-01 00:00:00
abstract::The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138049
更新日期:1985-01-01 00:00:00
abstract::Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136845
更新日期:1978-01-01 00:00:00
abstract::Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol fail...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136708
更新日期:1977-01-01 00:00:00
abstract::Sensitive radiometric assays were adapted to study the development and kinetics of meperidine and methadone N-demethylation and morphine glucuronidation by microsomes isolated from livers of fetal stump-tailed macaques (Macaca arctoides). Times in development selected for study were midterm, three-quarter term, near t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137259
更新日期:1979-01-01 00:00:00
abstract::L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxif...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139026
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...
journal_title:Pharmacology
pub_type: 新闻
doi:10.1159/000511279
更新日期:2020-11-20 00:00:00
abstract::The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000492576
更新日期:2018-01-01 00:00:00
abstract::The effect and mechanism of action of serotonin (5-HT) were studied in the pulmonary circulation of normal and diabetic rabbits. 5-HT (10, 50 and 100 nmol/l) produced a concentration-dependent increase in rabbit pulmonary arterial tension. Pulmonary arterial rings from diabetic rabbits were more responsive to 5-HT com...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139426
更新日期:1996-09-01 00:00:00
abstract::Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptor. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137467
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000440769
更新日期:2015-01-01 00:00:00
abstract::The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000082804
更新日期:2005-03-01 00:00:00
abstract::Erythrocytes can take up amino acids from the blood by using a variety of transport systems. GLYT is a key transport protein in the plasma membrane responsible for the Na(2+)-dependent uptake of glycine needed for glutathione biosynthesis. Certain cysteine-specific compounds, particularly mercuric chloride and 5,5'-di...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000074973
更新日期:2004-03-01 00:00:00
abstract::Under the specific conditions reported for the separate tests delta9-tetrahydrocannabinol (THC) did not elicit a mutagenic response in microbial and eukaryotic in vitro test systems. THC treatment to histidine auxotrophs of Salmonella typhimurium strains TA 98 (susceptible to frame shift mutation) and TA 100 (suscepti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136789
更新日期:1978-01-01 00:00:00
abstract::In an experimental model of haemorrhagic shock that causes 100% mortality in rats within 30 min, the intravenous bolus injection (20 micrograms/kg) of sulfated cholecystokinin octapeptide (CCK-8) induces a prompt and sustained rise in blood pressure and pulse amplitude, all treated animals still surviving at the end o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138480
更新日期:1988-01-01 00:00:00
abstract::Erythropoietin (EPO) has been used for the management of renal anemia. Recent studies suggest the pleiotropic properties of EPO in various tissues such as brain, kidney and vasculature. Diabetes mellitus is a major risk for development of vascular impairment. The aim of the present study was to investigate the hypothe...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000343963
更新日期:2013-01-01 00:00:00
abstract::Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000135848
更新日期:1977-01-01 00:00:00
abstract::Chronic administration of triazolam (0.25 mg/kg/day, i.p.) on days 1-8 and its withdrawal produced an anxiogenic reaction in mice as assessed in the mirrored-chamber test. Daily administration of bupropion (2 or 5 mg/kg, i.p.) prior to triazolam for 8 days prevented withdrawal-induced anxiety in mice. Triazolam withdr...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000087189
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000343634
更新日期:2013-01-01 00:00:00
abstract::We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335127
更新日期:2012-01-01 00:00:00
abstract::In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136926
更新日期:1975-01-01 00:00:00
abstract::The effects of a 1- or 24-hour pretreatment regimen with monophosphoryl lipid A (MLA, 35 micrograms/kg i.v.) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital-anesthetized dogs. Regional segment function (%SS) and myocardial blood flow were measured by sonomicrometry and the ra...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139329
更新日期:1995-09-01 00:00:00
abstract::Three highly reproducible experiments on drug interaction in normal human volunteers provided anomalous results: chronic halofenate administration shortened plasma antipyrine and bishydroxycoumarin half-lives but prolonged plasma warfarin half-lives. This dissociation in the effect produced by a chronically administer...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136892
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究
doi:10.1159/000492079
更新日期:2018-01-01 00:00:00
abstract::Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056100
更新日期:2001-05-01 00:00:00
abstract::Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8 +/- 10.6 nmol/l. As lesopitron did not affect the binding of [3H]paroxetine, involvement of the serotonin reuptake system in the effects of lesopitron is rejected. Lesopitron inhibits halope...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000079133
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000365932
更新日期:2014-01-01 00:00:00
abstract::We studied the action of beta-adrenergic agonists on Japanese quail erythrocyte carbonic anhydrase (CA) in vitro. Earlier we had reported that epinephrine increased CA activity by 14%; the present study focused on an attempt to increase the size of this response. Washed erythrocytes from reserpine-treated (1 mg/kg dai...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139223
更新日期:1994-08-01 00:00:00