Mechanism of action of the anti-shock effect of CCK-8: influence of CCK antagonists and of sympatholytic drugs.

abstract：AIMS:This study analyzed the role of the amiloride-sensitive component and the participation of the Na(+)/H(+) exchanger in renal responsiveness to vasoconstrictors in the isolated perfused rat kidney. METHODS:The renal responses to vasoconstrictors (angiotensin II, phenylephrine, vasopressin and KCl) were studied und...

journal_title：Pharmacology

authors： Vargas P,Wangensteen R,Rodríguez-Gómez I,Perez-Abud R,Osuna A,Quesada A,Vargas F

更新日期：2011-01-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：:The pathogenesis of aplastic anemia from chloramphenicol (CAP) remains uncertain. Recent observations suggest that metabolites of CAP generated by intestinal bacteria may play an important role in mediating hematotoxicity from the drug. Thus, it is possible that once in circulation and after passage through the liver,...

journal_title：Pharmacology

authors： Abou-Khalil WH,Yunis AA,Abou-Khalil S

更新日期：1988-01-01 00:00:00

abstract：:Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting to study the interaction of ZPC with rat brain receptors and spe...

journal_title：Pharmacology

authors： Blanchard JC,Boireau A,Julou L

更新日期：1983-01-01 00:00:00

abstract：AIMS:Recent studies have reported that intracellular calcium (Ca(2+)) mobilization is involved in homocysteine (Hcy)-induced endothelial dysfunction and the Na(+)/H(+) exchanger (NHE) is responsible for an increase in the intracellular Ca(2+) concentration in cardiovascular disease. We hypothesized that inhibition of t...

journal_title：Pharmacology

authors： Wu S,Gao X,Yang S,Liu L,Ge B,Yang Q

更新日期：2013-01-01 00:00:00

abstract：:The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10(-6) M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by si...

journal_title：Pharmacology

authors： Hall GE,Kenny AD

更新日期：1985-01-01 00:00:00

abstract：:A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykin...

journal_title：Pharmacology

authors： Mastrangelo D,Mathison R,Huggel H

更新日期：1983-01-01 00:00:00

abstract：:Neurochemical and neuropharmacological investigations with four ergot derivatives reveal differential pharmacodynamic effects of these compounds. Bromocriptine and CM 29-712 showed actions typical of postsynaptic dopamine receptor stimulants, in particular in the extrapyramidal system. CM 29-712 proved to be more pote...

journal_title：Pharmacology

authors： Vigouret JM,Bürki HR,Jaton AL,Züger PE,Loew DM

更新日期：1978-01-01 00:00:00

abstract：:The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersi...

journal_title：Pharmacology

authors： Paxton JW

更新日期：1984-01-01 00:00:00

abstract：:The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...

journal_title：Pharmacology

authors： Sirek A,Sirek OV,Policova Z,Kerekes A

更新日期：1977-01-01 00:00:00

abstract：:Renal hypoperfusion which occurs in hemorrhagic shock creates an environment in which cellular injury and organ dysfunction can occur during the episode of shock as well as reoxygenation and reperfusion. At the same time, mast cell degranulation which is observed during hemorrhage may have an additional deleterious ef...

journal_title：Pharmacology

authors： Akin MZ,Tunçel N,Gürer F,Kural N,Uslu S

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...

journal_title：Pharmacology

authors： Bruderer S,Marjason J,Sidharta PN,Dingemanse J

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

journal_title：Pharmacology

authors： Al-Rawi MB,Aleisa AM,Khattab MM

更新日期：2008-01-01 00:00:00

abstract：AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...

journal_title：Pharmacology

authors： Gradosova I,Zivna H,Palicka V,Hubena S,Svejkovska K,Zivny P

更新日期：2012-01-01 00:00:00

abstract：:The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

journal_title：Pharmacology

authors： Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

更新日期：2002-01-01 00:00:00

abstract：:The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development. As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amo...

journal_title：Pharmacology

authors： Meissner U,Allabauer I,Repp R,Rascher W,Dötsch J

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...

journal_title：Pharmacology

authors： Di Giusto G,Anzai N,Endou H,Torres AM

更新日期：2008-01-01 00:00:00

abstract：:The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous infusion of carvedilol or labetalol at a rate of 10 micrograms/kg/min resulted...

journal_title：Pharmacology

authors： Gellai M,DeWolf R,Ruffolo RR Jr

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Surgery plays a significant role in the comprehensive treatment of breast cancer, and opioids are often the first-choice analgesics in the perioperative period. However, recent studies showed that opioids may enhance the angiogenesis of breast cancer and the recurrence and metastasis of tumor cells. OBJECTI...

journal_title：Pharmacology

authors： Cheng S,Guo M,Liu Z,Fu Y,Wu H,Wang C,Cao M

更新日期：2019-01-01 00:00:00

abstract：:To determine the existence of beta 3-adrenoceptors in functional assays in isolated preparations for which data are lacking, we compared the effects of SR 58611A, a selective beta 3-adrenoceptor agonist, and isoprenaline in the guinea pig common bile duct, distal colon and urinary bladder. SR 58611A and isoprenaline r...

journal_title：Pharmacology

authors： De Ponti F,Gibelli G,Crema F,Lecchini S

更新日期：1995-11-01 00:00:00

abstract：:The antagonism of carbachol-induced contractions of guinea pig gallbladder smooth muscle strips via selective antagonists, methoctramine, HHSiD, pf-HHSiD and DABDMA has been investigated in order to find out the m-cholinoceptor subtype(s) of gallbladder smooth muscle. All m-cholinoceptor antagonists examined, displace...

journal_title：Pharmacology

authors： Ozkutlu U,Alican I,Karahan F,Onat F,Yegen BC,Ulusoy NB,Oktay S

更新日期：1993-06-01 00:00:00

abstract：:The calcium channel antagonist, nifedipine (0.1 microM), only slightly inhibited the response to the full alpha 1-adrenoceptor agonist, (-)-norepinephrine, in rat aorta, but nearly completely inhibited the response to the partial alpha 1-adrenoceptor agonist, (-)-dobutamine, indicating that (-)-norepinephrine primaril...

journal_title：Pharmacology

authors： Oriowo MA,Ruffolo RR Jr

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...

journal_title：Pharmacology

authors： Chen C,Ma C,Zhang Y,Zeng Y,Li Y,Wang W

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:We have reported that intermediate conductance Ca(2+)-activated K(+) channels (ImK) showed augmented expression in angiotensin II (AII) type 1 receptor-dependent manner in post-ischemic rat heart. ImK has tyrosine phosphorylation sequence in the C-terminus and motifs for NFkappaB and AP1 in the promoter. Whi...

journal_title：Pharmacology

authors： Terata Y,Saito T,Fujiwara Y,Hasegawa H,Miura H,Watanabe H,Chiba Y,Kibira S,Miura M

更新日期：2003-08-01 00:00:00

abstract：AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...

journal_title：Pharmacology

authors： Kelany ME,Hakami TM,Omar AH,Abdallah MA

更新日期：2016-01-01 00:00:00

abstract：:Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-mescaline in the pellet. 1.33 mumol/ml of chlorpromazine, trifluoperazine, fluphenazine, imipramine, desmethylimipramine, nortriptyline and amitriptyline inhibited the accu...

journal_title：Pharmacology

authors： Shah NS,Gulati OD

更新日期：1975-01-01 00:00:00

abstract：:We examined the properties of the drug interaction between morphine and 5-HT(3) receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 microl) into the hindpaw of the rats. Intrathecal morphine and m-CPBG (5-HT(3) receptor agonist) dose-dependen...

journal_title：Pharmacology

authors： Yoon MH,Bae HB,Choi JI,Kim SJ,Chung ST,Kim CM

更新日期：2006-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：:N-Tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) is neuroprotective in rat pups. We measured bcl-2, Bax and caspase-3 to determine the mechanisms. Seven-day-old rats had the right carotid artery ligated and were subjected to 2.5 h of 8% oxygen. Ten mg/kg of PTCK or vehicle was given intraperitoneally 15 min prior to ...

journal_title：Pharmacology

authors： Feng Y,LeBlanc MH

更新日期：2002-11-01 00:00:00