Effect of vasoactive intestinal peptide and naloxone combination on urinary N-acetyl-beta-D-glucosaminidase level and kidney histology of rats exposed to severe hemorrhage.

abstract：:The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...

journal_title：Pharmacology

authors： Arkonac BM,Kersten JR,Wynsen JC,Nijhawan N,Warltier DC

更新日期：1996-02-01 00:00:00

abstract：:In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...

journal_title：Pharmacology

authors： Sivaramakrishna N,Gulati OD

更新日期：1975-01-01 00:00:00

abstract：:In rats with lymphostatic encephalopathy the duration of harmine tremor was lengthened, and the brain concentrations of harmine decreased more slowly than in sham-operated controls. The tremor began simultaneously in both rat groups at coinciding brain concentrations of harmine. In rats with lymphostatic encephalopath...

journal_title：Pharmacology

authors： Back G,Seidel G

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...

journal_title：Pharmacology

authors： Hanioka N,Tanaka S,Moriguchi Y,Narimatsu S

更新日期：2012-01-01 00:00:00

abstract：:34 experienced marijuana users were divided into four equated groups of eight subjects each based on recognition memory test performance. One week later each group was retested following administration of marijuana containing 0, 5, 10 or 15 mg delta9-tetrahydrocannabinol. A dose-related effect of marijuana on pulse ra...

journal_title：Pharmacology

authors： Miller L,Cornett T,Drew W,McFarland D,Brightwell D,Wikler A

更新日期：1977-01-01 00:00:00

abstract：:The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had ...

journal_title：Pharmacology

authors： Saito T,Saeed M,Bing RJ

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：:The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：1999-10-01 00:00:00

abstract：:Distinct signal transduction pathways have been shown to regulate injury responses and regeneration in peripheral nerves. In the present investigation, the time courses of the induction of phospho-MAPK/ERK1/2 and of phospho-STAT3 were investigated in the dorsal root ganglia (DRG) and in the sciatic nerve of rats follo...

journal_title：Pharmacology

authors： Donnerer J,Liebmann I,Schicho R

更新日期：2005-11-01 00:00:00

abstract：:Ulcerative colitis is characterized by dysfunctional motility. Our main objective in this investigation was to study the effect of an acetic acid-induced ulcerative colitis on the expression and function of beta(3)-adrenoceptors in the rat colon. Inflammation was induced by administering acetic acid intrarectally into...

journal_title：Pharmacology

authors： Khan I,Hussein SM,Oriowo M

更新日期：2002-02-01 00:00:00

abstract：:We studied the action of beta-adrenergic agonists on Japanese quail erythrocyte carbonic anhydrase (CA) in vitro. Earlier we had reported that epinephrine increased CA activity by 14%; the present study focused on an attempt to increase the size of this response. Washed erythrocytes from reserpine-treated (1 mg/kg dai...

journal_title：Pharmacology

authors： Igbo IN,Reigel CE Jr,Greene IM,Kenny AD

更新日期：1994-08-01 00:00:00

abstract：:Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...

journal_title：Pharmacology

authors： Stewart JJ

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

journal_title：Pharmacology

authors： Dan K,Katoh N,Matsuoka T,Fujinami K

更新日期：2019-06-06 00:00:00

abstract：:delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...

journal_title：Pharmacology

authors： Sofia RD,Diamantis W,Harrison JE,Melton J

更新日期：1978-01-01 00:00:00

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：:The effects of sammarium (Sm3+) on drug responsiveness of the isolated guinea pig ileum were studied. The lanthanid at the concentration of 2x10(-4) M reduced responsiveness to acetylcholine, histamine and submaximal concentrations of potassium. The maximum response to potassium and the responsiveness to barium remain...

journal_title：Pharmacology

authors： Turrin MA,De Moraes S

更新日期：1977-01-01 00:00:00

abstract：:The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...

journal_title：Pharmacology

authors： Feldman S,Putcha L

更新日期：1977-01-01 00:00:00

abstract：:Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...

journal_title：Pharmacology

authors： Pan HP,Fouts JR

更新日期：1979-01-01 00:00:00

abstract：:A rapid and sensitive gas chromatographic method for the determination of the beta-adrenergic agent isoxsuprine in human plasma has been developed. The procedure involves the extraction of the drug with ether and an internal standard (propranolol) from plasma at alkaline pH, solvent evaporation, and the formation of a...

journal_title：Pharmacology

authors： Cova D,Colombo R,Cellini G

更新日期：1983-01-01 00:00:00

abstract：:The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...

journal_title：Pharmacology

authors： Nègre-Salvayre A,Affany A,Hariton C,Salvayre R

更新日期：1991-01-01 00:00:00

abstract：:Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...

journal_title：Pharmacology

authors： Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

更新日期：2011-01-01 00:00:00

abstract：:The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...

journal_title：Pharmacology

authors： Frey HH

更新日期：1986-01-01 00:00:00

abstract：AIMS:To compare the bioavailability of a new oromucosal formulation of flurbiprofen 8.75-mg lozenges, developed by Alfa Wassermann S.p.A. (test drug) to that of marketed flurbiprofen 8.75-mg lozenges (Benactiv Gola®, reference drug). METHODS:This was an open, randomised, two-period, crossover, pharmacokinetic (PK) stu...

journal_title：Pharmacology

authors： Matzneller P,Burian A,Martin W,Annoni O,Lauro V,Tacchi R,Brunner M,Zeitlinger M

更新日期：2012-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...

journal_title：Pharmacology

authors： Stockbrügger RW

更新日期：1988-01-01 00:00:00

abstract：:Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vit...

journal_title：Pharmacology

authors： Strandberg TE,Kuusi T,Tilvis RS,Miettinen TA

更新日期：1983-01-01 00:00:00

abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...

journal_title：Pharmacology

authors： Zhang LY,Zou JJ,Liu ZM

更新日期：2011-01-01 00:00:00

abstract：:In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising ...

journal_title：Pharmacology

authors： Greven J,van Eys B,Jacobs W

更新日期：1975-01-01 00:00:00

abstract：:A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the prep...

journal_title：Pharmacology

authors： Iida S,Itoh Y,Moriwaki K

更新日期：1982-01-01 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by ...

journal_title：Pharmacology

authors： Mihas AA,Maliakkal RJ,Mihas TA,Kanji VK,Markov AK

更新日期：1997-01-01 00:00:00