Abstract:
:Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Mihas AA,Maliakkal RJ,Mihas TA,Kanji VK,Markov AKdoi
10.1159/000139468subject
Has Abstractpub_date
1997-01-01 00:00:00pages
43-8issue
1eissn
0031-7012issn
1423-0313journal_volume
54pub_type
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