Abstract:
:The antagonism of carbachol-induced contractions of guinea pig gallbladder smooth muscle strips via selective antagonists, methoctramine, HHSiD, pf-HHSiD and DABDMA has been investigated in order to find out the m-cholinoceptor subtype(s) of gallbladder smooth muscle. All m-cholinoceptor antagonists examined, displaced the concentration-response curves to the right parallel in a concentration-dependent manner without affecting the maximum response. Schild analysis of data was consistent with competitive antagonism. -log KB values of the antagonists were 7.37 for HHSiD, 7.53 for pf-HHSiD, 6.58 for DABDMA and 7.60 for methoctramine. These results, together with the high affinity of pirenzepine and low affinities of 4-DAMP and AF-DX 116, indicate that the m-cholinoceptors of the guinea pig gallbladder which mediate cholinergic contractions are not of m1-, m2- and m3- subtypes but seem likely to be of m4-subtype.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Ozkutlu U,Alican I,Karahan F,Onat F,Yegen BC,Ulusoy NB,Oktay Sdoi
10.1159/000139061subject
Has Abstractpub_date
1993-06-01 00:00:00pages
308-14issue
6eissn
0031-7012issn
1423-0313journal_volume
46pub_type
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