The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice.

abstract：:We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...

journal_title：Pharmacology

authors： Lee TS,Kaku T,Takebayashi S,Uchino T,Miyamoto S,Hadama T,Perez-Reyes E,Ono K

更新日期：2006-01-01 00:00:00

abstract：AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...

journal_title：Pharmacology

authors： Fakhoury W,Lockhart I,Kotchie RW,Aagren M,LeReun C

更新日期：2008-01-01 00:00:00

abstract：:86Rb efflux assay was used to investigate the effect of cromakalim, pinacidil and P1075 in guinea pig urinary bladder strips. The type of K channel opened by cromakalim and pinacidil was determined using specific K channel blockers through 86Rb efflux assay in detrusor strips. Cromakalim, pinacidil and P1075 all three...

journal_title：Pharmacology

authors： Trivedi S,Stetz S,Levin R,Li J,Kau S

更新日期：1994-09-01 00:00:00

abstract：:The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...

journal_title：Pharmacology

authors： Batzri S,Harmon JW

更新日期：1986-01-01 00:00:00

abstract：:Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...

journal_title：Pharmacology

authors： Pearce FL

更新日期：1986-01-01 00:00:00

abstract：:The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participa...

journal_title：Pharmacology

authors： Boismare F,Le Poncin M,Lefrançois J,Lecordier JC

更新日期：1978-01-01 00:00:00

abstract：:This study was performed to investigate the effect of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity as measured in mice, and the morphine-induced hyperactivity was inhibited dose-depen...

journal_title：Pharmacology

authors： Yoon IS,Kim HS,Hong JT,Lee MK,Oh KW

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...

journal_title：Pharmacology

authors： Bruderer S,Marjason J,Sidharta PN,Dingemanse J

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...

journal_title：Pharmacology

authors： Li J,Xiao Z,Hu X,Li Y,Zhang X,Zhang S,Gong W,Zhao J,Ye X

更新日期：2017-01-01 00:00:00

abstract：:Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...

journal_title：Pharmacology

authors： Markov AK,Farias LA,Bennett WS,Subramony C,Mihas AA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...

journal_title：Pharmacology

authors： Salvo F,Miroddi M,Alibrandi A,Calapai F,Cafeo V,Mancari F,Gangemi S,Caputi AP,Calapai G

更新日期：2013-01-01 00:00:00

abstract：:The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious dogs and were compared with the effects of porcine motilin (pMTL), EM-523 and EM-574. In the interdigestive state, intravenous and oral administration of mitemcin...

journal_title：Pharmacology

authors： Ozaki K,Yogo K,Sudo H,Onoma M,Kamei K,Akima M,Koga H,Itoh Z,Omura S,Takanashi H

更新日期：2007-01-01 00:00:00

abstract：:GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...

journal_title：Pharmacology

authors： Kozielewicz P,Grafton G,Sajkowska-Kozielewicz JJ,Barnes NM

更新日期：2019-01-01 00:00:00

abstract：:The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, wa...

journal_title：Pharmacology

authors： Cavaliere TA,Taylor DG,Kerwin LJ,Antonaccio MJ

更新日期：1980-01-01 00:00:00

abstract：:The purpose of these studies was to evaluate the effects of the peptidoleukotriene (LT) receptor antagonist, ICI 198615, on the vasopressor responses produced by LTC4, LTD4 and LTE4. Conscious, normotensive rats were prepared with arterial and venous catheters for measurement of changes in arterial blood pressure and ...

journal_title：Pharmacology

authors： Smith EF 3rd,Slivjak MJ

更新日期：1990-01-01 00:00:00

abstract：:We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partially purified cyclooxygenase (COX)-1 and COX-2 preparations in order to clarify the pharmacological profile of the compound as an ...

journal_title：Pharmacology

authors： Ogino K,Hatanaka K,Kawamura M,Katori M,Harada Y

更新日期：1997-07-01 00:00:00

abstract：:A multicenter, placebo-controlled, double-dummy, randomized, parallel-group, double-blind study was conducted to verify the hypothesis of noninferiority for single-dose administration of zaltoprofen 160 mg, a nonsteroidal anti-inflammatory drug, compared with loxoprofen sodium 60 mg (loxoprofen), in terms of antipyret...

journal_title：Pharmacology

authors： Azuma A,Kudoh S,Nakashima M,Nagatake T

更新日期：2011-01-01 00:00:00

abstract：:Increased concentrations of immunoreactive methionine-enkephalin but not leucine-enkephalin were measured in fractions of cerebrospinal fluid perfusate collected from ventricular-cisternally perfused, urethane-anesthetized rats exposed to a mixture of 75% nitrous oxide/25% oxygen for 60 min. These findings suggest tha...

journal_title：Pharmacology

authors： Quock RM,Kouchich FJ,Tseng LF

更新日期：1985-01-01 00:00:00

abstract：:The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight ...

journal_title：Pharmacology

authors： Torres IJ,Litterst CL,Guarino AM

更新日期：1978-01-01 00:00:00

abstract：:We investigated the antihypertensive effect of 5-HT1A agonist (buspirone) and 5-HT2B antagonists (SB204741 and SB200646) in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats. Experiments were divided into two sets: in the first set, sham-operated control and DOCA-treated hypertensive rats received busp...

journal_title：Pharmacology

authors： Shingala JR,Balaraman R

更新日期：2005-03-01 00:00:00

abstract：:Three carcinogens with different requirements for activation were used to generate sister chromatid exchange (SCE) in cultured lymphocytes from 22 untreated patients with solid tumors. These data were compared to SCEs produced by incubating lymphocytes, from 44 normal persons, with the same carcinogens. In vitro treat...

journal_title：Pharmacology

authors： Wiencke JK,Vosika J,Johnson P,Wang N,Garry VF

更新日期：1982-01-01 00:00:00

abstract：:Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

journal_title：Pharmacology

authors： Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates lipid metabolism. Recently, PPARgamma was reported to be a negative regulator in the immune system. Eosinophils also express PPARgamma, however, the role of PPARgamma in eosinophil functions is not well understood. Surfac...

journal_title：Pharmacology

authors： Matsuwaki Y,Ueki S,Adachi T,Oyamada H,Kamada Y,Yamaguchi K,Kanda A,Hamada K,Kayaba H,Chihara J

更新日期：2005-07-01 00:00:00

abstract：AIM:Superfluous reactive nitrogen and oxygen species generation is implicated in the damage of tissues at sites of inflammation where activated neutrophils and macrophages are involved. This study was conducted to investigate whether the beneficial effects of carvedilol involve modulation of respiratory burst, degranul...

journal_title：Pharmacology

authors： Pecivová J,Macicková T,Lojek A,Gallova L,Cíz M,Nosál' R,Holománová D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...

journal_title：Pharmacology

authors： Hanioka N,Tanaka S,Moriguchi Y,Narimatsu S

更新日期：2012-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：:Oxygen radicals have been considered to be important regulatory molecules in Helicobacter pylori-induced gastric ulceration and carcinogenesis. H. pylori-induced inflammation has been shown to be associated with cyclooxygenase-2 (COX-2) expression in experimental animals and human patients. This study aimed to determi...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：2002-12-01 00:00:00

abstract：:In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the vi...

journal_title：Pharmacology

authors： Kandasamy SB

更新日期：1980-01-01 00:00:00

abstract：:The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...

journal_title：Pharmacology

authors： Trush MA,Van Dyke K

更新日期：1978-01-01 00:00:00