Abstract:
:The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) addition of promethazine after initiation of phagocytosis and CL. The presence of promethazine inhibited light emission in all cases. The data suggest that promethazine interferes with the generation and/or subsequent activity of those reactive forms of oxygen which contribute to CL.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Trush MA,Van Dyke Kdoi
10.1159/000136787subject
Has Abstractpub_date
1978-01-01 00:00:00pages
314-20issue
6eissn
0031-7012issn
1423-0313journal_volume
16pub_type
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