Abstract:
:Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of either sex. The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats. The toxicity of the compounds was reflected by determination of their approximate LD50 in albino mice. An attempt has also been made to correlate their structure-activity relationship.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Tandon M,Kumar P,Pande K,Bhalla TN,Barthwal JPdoi
10.1159/000138130subject
Has Abstractpub_date
1985-01-01 00:00:00pages
260-7issue
5eissn
0031-7012issn
1423-0313journal_volume
31pub_type
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