Periplaneta Americana Extract May Attenuate Renal Fibrosis through Inhibiting Janus Tyrosine Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway.

abstract：:The aim of this study was to determine whether transforming growth factor-beta1 (TGF-beta1) induces the synthesis, release and gene expression of urokinase-type plasminogen activator (uPA) in hepatic stellate cells. In addition to stimulating collagen production, TGF-beta1 induced the morphological and phenotypical ch...

journal_title：Pharmacology

authors： Pérez-Liz G,Flores-Hernández J,Arias-Montaño JA,Reyes-Esparza JA,Rodríguez-Fragoso L

更新日期：2005-01-01 00:00:00

abstract：:A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykin...

journal_title：Pharmacology

authors： Mastrangelo D,Mathison R,Huggel H

更新日期：1983-01-01 00:00:00

abstract：:Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that ca...

journal_title：Pharmacology

authors： Dai S,Ogle CW,Cho CH

更新日期：1986-01-01 00:00:00

abstract：:The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...

journal_title：Pharmacology

authors： Hui SC,Ogle CW,Wang Z,An Y,Hu YH

更新日期：1989-01-01 00:00:00

abstract：:The transketolase activity (TKA) of the white and red blood cells of oral contraceptive users was studied in an unselected sample population. Compared with healthy controls of corresponding age, the white cell TKA in the oral contraceptive groups was lowered in about 30%. The red cell TKA was lowered in about 15% of...

journal_title：Pharmacology

authors： Markkanen T,Himanen P,Peltola O

更新日期：1974-01-01 00:00:00

abstract：:In a randomized three-phase crossover study, 12 healthy male volunteers were given three 12-hourly 500-mg doses of erythromycin base, as enteric coated pellets in capsules (2 X 250 mg), erythromycin stearate tablet (1 X 500 mg), or erythromycin ethylsuccinate sachet (1 X 500 mg). The reaction time after administration...

journal_title：Pharmacology

authors： Tjandramaga TB,Van Hecken A,Mullie A,Verbesselt R,De Schepper PJ,Verbist L,Josefsson K

更新日期：1984-01-01 00:00:00

abstract：:The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...

journal_title：Pharmacology

authors： Lee SK

更新日期：2014-01-01 00:00:00

abstract：:Erythrocytes can take up amino acids from the blood by using a variety of transport systems. GLYT is a key transport protein in the plasma membrane responsible for the Na(2+)-dependent uptake of glycine needed for glutathione biosynthesis. Certain cysteine-specific compounds, particularly mercuric chloride and 5,5'-di...

journal_title：Pharmacology

authors： McCormick SJ,Tunnicliff G

更新日期：2004-03-01 00:00:00

abstract：:In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...

journal_title：Pharmacology

authors： DeMoraes S,Capaz FR

更新日期：1977-01-01 00:00:00

abstract：AIM:An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS:Forty-five patients with hypercholesterolemia and as...

journal_title：Pharmacology

authors： Riccioni G,Vitulano N,Mancini B,Zanasi A,D'Orazio N

更新日期：2010-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00

abstract：:The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...

journal_title：Pharmacology

authors： Bernard F,Jouquey S,Hamon G

更新日期：1991-01-01 00:00:00

abstract：:The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...

journal_title：Pharmacology

authors： Frey HH

更新日期：1986-01-01 00:00:00

abstract：:The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly ...

journal_title：Pharmacology

authors： Nishiyama K,Nishikawa H,Kato K,Miyamoto M,Tsukamoto T,Hirai K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

journal_title：Pharmacology

authors： Kim YO,Song JA,Kim WM,Yoon MH

更新日期：2020-01-01 00:00:00

abstract：:Chronic exposure to cold increases the growth of brown adipose tissue and the resistance to more severe cold, thus improving thermogenesis. The present study examined the possibility that dietary compounds can modify cold acclimation. Adenosine (ADO) or adenine (ADE) were administered in drinking water (0.05%, w/v) fo...

journal_title：Pharmacology

authors： Nishimura M,Moriya M,Saitoh M,Murakoshi N,Shimizu Y

更新日期：1999-09-01 00:00:00

abstract：:The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean fecal blood loss of 4.2 ml/day, compared with subject...

journal_title：Pharmacology

authors： Arnold JD,Berger AE

更新日期：1983-01-01 00:00:00

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...

journal_title：Pharmacology

authors： Watanabe Y,Ohata K,Fukanoki A,Fujimoto N,Matsumoto M,Nessa N,Toba H,Kobara M,Nakata T

更新日期：2020-01-01 00:00:00

abstract：:Fenofibrate is widely used in clinical practice, but its influence on chronic endoplasmic reticulum (ER) stress induced by feeding a high-calorie and high-cholesterol diet (HCD) has still not been studied. We thus investigated its effects on the liver of the nonalcoholic fatty liver disease (NAFLD) mouse model. Male C...

journal_title：Pharmacology

authors： Zhang N,Lu Y,Shen X,Bao Y,Cheng J,Chen L,Li B,Zhang Q

更新日期：2015-01-01 00:00:00

abstract：:Tramadol, a central analgesic acting on serotonin neurotransmission, is often co-used with ondansetron, a 5-HT(3) antagonist, for the management of postoperative pain to decrease nausea and vomiting. The aim of the study is to test the hypothesis that this drug combination raises tramadol requirement by patient-contro...

journal_title：Pharmacology

authors： Vale C,Oliveira F,Assunção J,Fontes-Ribeiro C,Pereira F

更新日期：2011-01-01 00:00:00

abstract：:The ovariectomized (OVX) rat, as an established animal model of human osteoporosis, was adopted in the present experiment to study the protective effects of sodium daidzein sulfonate (SDS) on trabecular bone. Six-month-old Sprague-Dawley rats were sham-operated or ovariectomized. Five days later, the OVX rats were ran...

journal_title：Pharmacology

authors： Ren P,Ji H,Shao Q,Chen X,Han J,Sun Y

更新日期：2007-01-01 00:00:00

abstract：:Serotonin-depleting lesions of midbrain raphe (extensive lesions located within dorsal and partly median raphe muclei) induced intraspecific agressiveness in grouped Wistar male rats but failed to increase mouse-killing behaviour. Rats which had lesions in the lateral midbrain did not display intraspecific aggression ...

journal_title：Pharmacology

authors： Kostowski W,Cxlonkowski A,Markowdka L,Markiewicz L

更新日期：1975-01-01 00:00:00

abstract：:Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...

journal_title：Pharmacology

authors： Babbini M,Gaiardi M,Bartoletti M

更新日期：1978-01-01 00:00:00

abstract：:The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

journal_title：Pharmacology

authors： Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

更新日期：2002-01-01 00:00:00

abstract：:The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...

journal_title：Pharmacology

authors： Chiu TH

更新日期：1981-01-01 00:00:00

abstract：:Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...

journal_title：Pharmacology

authors： Tandon M,Kumar P,Pande K,Bhalla TN,Barthwal JP

更新日期：1985-01-01 00:00:00

abstract：:The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...

journal_title：Pharmacology

authors： Longo VG,Loizzo A

更新日期：1978-01-01 00:00:00

abstract：:Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...

journal_title：Pharmacology

authors： Pan HP,Fouts JR

更新日期：1979-01-01 00:00:00