Abstract:
:The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therapeutic proteins in pediatric subjects. The CL of a therapeutic protein estimated from allometric scaling using REE was approximately 2-fold higher than that using body weight (BW) in younger children. For some monoclonal antibodies, REE was a better predictor than BW to estimate CL in pediatric subjects. Overall results suggest that the relationship of CL with REE and its clinical importance in therapeutic proteins need to be investigated further for pediatric subjects.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Lee SKdoi
10.1159/000362562subject
Has Abstractpub_date
2014-01-01 00:00:00pages
225-8issue
5-6eissn
0031-7012issn
1423-0313pii
000362562journal_volume
93pub_type
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