Abstract:
:Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups according to polarity and molecular size on a Sephadex LH 20 column. The present paper describes a further study within a bile-derived metabolite group, which proved to be particularly heterogeneous. It contained more than a dozen metabolites, which were conjugates of four different aglycons including the parent danthron. 1H NMR spectral data for danthron monosulfate and monoglucuronide are also presented.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Sund RB,Junker T,Malterud KEdoi
10.1159/000139852subject
Has Abstractpub_date
1993-10-01 00:00:00pages
134-7eissn
0031-7012issn
1423-0313journal_volume
47 Suppl 1pub_type
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