Abstract:
:Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct regulation of GST activities by human growth hormone (hGH). Maintenance of GST activities in this primary cultured hepatocyte system for 8 days allowed subsequent study of GST regulation by hGH. Protein concentration, cell number, DNA content, and viability did not significantly differ (p > 0.05) between the untreated and hGH (2 micrograms/ml)-treated hepatocytes. However, hGH treatment decreased mu GST activity (p < 0.05), whereas alpha GST activity was unaltered. As positive controls for our culture system and to corroborate our findings, we examined phenobarbital induction of GST activities and hGH regulation of certain cytochrome P450-dependent testosterone hydroxylases.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Grgurevich S,Greene FEdoi
10.1159/000139312subject
Has Abstractpub_date
1995-06-01 00:00:00pages
13-23issue
1eissn
0031-7012issn
1423-0313journal_volume
51pub_type
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