Protective effects of AICAriboside in the globally ischemic isolated cat heart.

abstract：OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...

journal_title：Pharmacology

authors： Chen C,Ma C,Zhang Y,Zeng Y,Li Y,Wang W

更新日期：2014-01-01 00:00:00

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：:Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...

journal_title：Pharmacology

authors： Stewart JJ

更新日期：1984-01-01 00:00:00

abstract：:The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...

journal_title：Pharmacology

authors： Jorgensen R,Norklit Roed S,Heding A,Elling CE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

journal_title：Pharmacology

authors： Kim YO,Song JA,Kim WM,Yoon MH

更新日期：2020-01-01 00:00:00

abstract：:The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...

journal_title：Pharmacology

authors： Longo VG,Loizzo A

更新日期：1978-01-01 00:00:00

abstract：:An increase in pulmonary vascular resistance (PVR) after cyclooxygenase inhibition (COI) is well documented in the dog, but the site of vasoconstriction to chemically distinct cyclooxygenase inhibitors is largely unknown. The purpose of the present study was to examine and compare equimolar concentrations of three che...

journal_title：Pharmacology

authors： Endrédi J,el-Kashef HA,Hofman WF,Ehrhart IC

更新日期：1992-01-01 00:00:00

abstract：:The present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (CBS) with thiols. Studies were performed using the monothiol glutathione (GSH), the dithiol dithiothreitol (DTT) and the thiol enzymes papain and H+/K(+)-ATPase. UV-vis spectra showed that CBS forms complexes with GSH and D...

journal_title：Pharmacology

authors： Beil W,Bierbaum S,Sewing KF

更新日期：1993-08-01 00:00:00

abstract：:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...

journal_title：Pharmacology

authors： Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

更新日期：1987-01-01 00:00:00

abstract：:Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase and ethylmorphine demethylase. The inhibition constants vary depending on the ind...

journal_title：Pharmacology

authors： Fujino T,West D,Park SS,Gelboin HV

更新日期：1990-01-01 00:00:00

abstract：:A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase. Phenylbutazone, aminopyrine, 1,3-diphenylisobenzofuran, paracetamol, p-aminophenol, p-phenetidine and other o- and m-substituted aminop...

journal_title：Pharmacology

authors： Baumann J,von Bruchhausen F,Wurm G

更新日期：1983-01-01 00:00:00

abstract：:We examined the properties of the drug interaction between morphine and 5-HT(3) receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 microl) into the hindpaw of the rats. Intrathecal morphine and m-CPBG (5-HT(3) receptor agonist) dose-dependen...

journal_title：Pharmacology

authors： Yoon MH,Bae HB,Choi JI,Kim SJ,Chung ST,Kim CM

更新日期：2006-01-01 00:00:00

abstract：:Interferons are known to prevent liver collagen by an antifibrogenic mechanism that involves mRNA procollagen regulation. The aim of the present work was to determine whether interferon could also decrease collagen by increasing its degradation. Fibrosis was induced in male Wistar rats by double ligation and section o...

journal_title：Pharmacology

authors： Rodríguez-Fragoso L,González MP,Muriel P

更新日期：1995-12-01 00:00:00

abstract：:We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK(1) and NK(2) receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotrien...

journal_title：Pharmacology

authors： Tanpo T,Nabe T,Yasui K,Kamiki T,Kohno S

更新日期：2000-05-01 00:00:00

abstract：:N-Tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) is neuroprotective in rat pups. We measured bcl-2, Bax and caspase-3 to determine the mechanisms. Seven-day-old rats had the right carotid artery ligated and were subjected to 2.5 h of 8% oxygen. Ten mg/kg of PTCK or vehicle was given intraperitoneally 15 min prior to ...

journal_title：Pharmacology

authors： Feng Y,LeBlanc MH

更新日期：2002-11-01 00:00:00

abstract：:The purpose of these studies was to evaluate the effects of the peptidoleukotriene (LT) receptor antagonist, ICI 198615, on the vasopressor responses produced by LTC4, LTD4 and LTE4. Conscious, normotensive rats were prepared with arterial and venous catheters for measurement of changes in arterial blood pressure and ...

journal_title：Pharmacology

authors： Smith EF 3rd,Slivjak MJ

更新日期：1990-01-01 00:00:00

abstract：:The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...

journal_title：Pharmacology

authors： Johnson KM,Dewey WL

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...

journal_title：Pharmacology

authors： Bruderer S,Marjason J,Sidharta PN,Dingemanse J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...

journal_title：Pharmacology

authors： Dannenberg L,Trojovsky K,Ayhan A,Helten C,Zako S,M'Pembele R,Mourikis P,Benkhoff M,Ignatov D,Sarabhai T,Petzold T,Huhn-Wientgen R,Zeus T,Kelm M,Levkau B,Polzin A

更新日期：2020-11-20 00:00:00

abstract：:Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...

journal_title：Pharmacology

authors： Ertunc M,Sara Y,Korkusuz P,Onur R

更新日期：2009-01-01 00:00:00

abstract：:In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising ...

journal_title：Pharmacology

authors： Greven J,van Eys B,Jacobs W

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...

journal_title：Pharmacology

authors： Castellão-Santana LM,Yumi Abiko P,Ambiel CR,Peixoto AR,Noronha-Matos JB,Correia-de-Sá P,Alves-Do-Prado W

更新日期：2019-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...

journal_title：Pharmacology

authors： Lin HC,Cheng TH,Chen YC,Juan SH

更新日期：2004-06-01 00:00:00

abstract：:Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure liquid chromatographic assay method. Comparison with newly synthesized,...

journal_title：Pharmacology

authors： Danhof M,Teunissen MW,Breimer DD

更新日期：1982-01-01 00:00:00

abstract：:Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating....

journal_title：Pharmacology

authors： Sivadjian J

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...

journal_title：Pharmacology

authors： Yildiz Akar F,Celikyurt IK,Ulak G,Mutlu O

更新日期：2009-01-01 00:00:00

abstract：:Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When N...

journal_title：Pharmacology

authors： Marshall CE,Dadmarz M,Hofford JM,Gottheil E,Vogel WH

更新日期：2003-03-01 00:00:00

abstract：:Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that ca...

journal_title：Pharmacology

authors： Dai S,Ogle CW,Cho CH

更新日期：1986-01-01 00:00:00