Abstract:
:The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% inhibition of the uptake of 3H-tryptophan and 3H-choline were 33 and 16 muM, respectively. Kinetic analysis showed that inhibition of both compounds were consistent with a noncompetitive mechanism. The pretreatment of mice with doses of 10, 30 or 100 mg/kg delta9-THC had no effect on the subsequent in vitro synaptosomal uptake of either 3H-tryptophan or 3H-choline into forebrain synaptosomes.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Johnson KM,Dewey WLdoi
10.1159/000136839subject
Has Abstractpub_date
1978-01-01 00:00:00pages
83-7issue
2eissn
0031-7012issn
1423-0313journal_volume
17pub_type
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