Abstract:
:The influence of repeated administration of histamine on lithium-induced state dependency has been investigated. A single-trial step-down inhibitory avoidance task was used to assess memory in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg), immediately after training (post-training), impaired inhibitory avoidance memory on the test day. Pre-test administration of lithium reversed amnesia induced by the drug given after training, with the maximum response at a dose of 10 mg/kg. Repeated intracerebroventricular (i.c.v.) administration of histamine (20 microg/mouse) for 3 consecutive days followed by 5 days of no drug treatment improved memory retrieval of inhibitory avoidance by a pre-test lower dose (5 mg/kg i.p.) of lithium. In contrast, 3 days of i.c.v. injections of both the histamine H1 receptor antagonist pyrilamine (40 microg/mouse) and the histamine H2 receptor antagonist ranitidine (6.25 and 12.5 microg/mouse) prevented the improving effect of pre-test lithium (10 mg/kg i.p.) on memory retrieval. The results suggest that the repeated administration of histaminergic agents may induce a sensitization which affects the memory impairment induced by lithium.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Zarrindast MR,Parsaei L,Ahmadi Sdoi
10.1159/000111760subject
Has Abstractpub_date
2008-01-01 00:00:00pages
187-94issue
2eissn
0031-7012issn
1423-0313pii
000111760journal_volume
81pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000330742
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The primary aim of the present investigation was to determine and compare the pharmacokinetic (PK) profiles of inorganic phosphate in serum and urine after intravenous administration of sodium glycerophosphate and inorganic sodium phosphate. Additionally, study product safety profiles were evaluated. SUBJECT...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000331341
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000351704
更新日期:2013-01-01 00:00:00
abstract:AIMS:Accumulation of advanced glycation end products (AGEs) plays a pivotal role in the mechanism by which aging contributes to osteoarthritis (OA). In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-α (TNF-α) and matrix metallopr...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000345345
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000502789
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Fluorofenidone [1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone, AKF-PD], a novel pyridone agent, showed potent antifibrotic properties. The aim of the present study was to investigate the effects of AKF-PD on diabetic nephropathy and kidney fibrosis, and to obtain an insight into its mechanisms of action. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000329419
更新日期:2011-01-01 00:00:00
abstract::The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339072
更新日期:2012-01-01 00:00:00
abstract::In the present paper, two experiments are performed to test the efficacy of the intravenous administration of hypertonic glucose (25 or 50%) in alcoholic intoxication. In a first experiment, 10 healthy, nonstarved volunteers, received 15 min after the ingestion of 1.0 g/kg alcohol, 40 ml of 25% glucose i.v., the same ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137769
更新日期:1983-01-01 00:00:00
abstract::43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days. Both drugs produced an improvement in subjective symptoms by day 7, although the most rapid analgesic effect was obtained with suprofen. Patients receiving suprofen experienced a signi...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137898
更新日期:1983-01-01 00:00:00
abstract:AIM:To study whether rosiglitazone prevents the development of diabetic nephropathy through reduction of reactive oxygen species and its downstream signal transduction pathways. METHODS:The rats were intraperitoneally injected with streptozotocin to induce diabetes, meanwhile the rats in the therapeutic groups were gi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000103232
更新日期:2007-01-01 00:00:00
abstract::This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028223
更新日期:1998-07-01 00:00:00
abstract::The aim of the present study was to compare the cardioprotective properties of long-acting calcium channel antagonist pranidipine with amlodipine in rat model of heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization the surviving rats were randomized for the oral administration of low-d...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091746
更新日期:2006-01-01 00:00:00
abstract::The effects of alpha-adrenergic agonists on 45Ca efflux from slices of rat liver were studied and the results compared to earlier studies on the rabbit aorta. Norepinephrine and phenylephrine (PE) cause a stimulation of 45Ca efflux which was due to alpha 1-receptor activation. The mitochondrial uncoupler dinitrophenol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137952
更新日期:1984-01-01 00:00:00
abstract::The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136819
更新日期:1978-01-01 00:00:00
abstract:AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335491
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000507937
更新日期:2020-11-03 00:00:00
abstract::We established an Ascaris-induced biphasic skin allergic reaction in mice. In the early-phase reaction (EPR), mast cell degranulation was observed, and tranilast inhibited ear edema. In mast-cell-deficient mice (WBB6F(1)-W/W(V) mice), ear edema in the EPR disappeared, whereas that in the late-phase reaction (LPR) rema...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056117
更新日期:2001-01-01 00:00:00
abstract::The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137973
更新日期:1984-01-01 00:00:00
abstract::Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulati...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000157626
更新日期:2008-01-01 00:00:00
abstract::In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136926
更新日期:1975-01-01 00:00:00
abstract::The cardiovascular effects of SKP-450, a newly synthesized potassium channel activator, and its two major metabolites SKP-818 and SKP-310 were evaluated on isolated rat aorta and in freely moving rats and anesthetized beagle dogs. The rank order of potency in relaxing rat aorta precontracted with norepinephrine was SK...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028188
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000500314
更新日期:2019-01-01 00:00:00
abstract::We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partially purified cyclooxygenase (COX)-1 and COX-2 preparations in order to clarify the pharmacological profile of the compound as an ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139511
更新日期:1997-07-01 00:00:00
abstract::The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056137
更新日期:2001-01-01 00:00:00
abstract::Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000135848
更新日期:1977-01-01 00:00:00
abstract::The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138176
更新日期:1986-01-01 00:00:00
abstract::Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094521
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. METHODS:7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. RESU...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000235997
更新日期:2009-01-01 00:00:00
abstract::The antagonism of carbachol-induced contractions of guinea pig gallbladder smooth muscle strips via selective antagonists, methoctramine, HHSiD, pf-HHSiD and DABDMA has been investigated in order to find out the m-cholinoceptor subtype(s) of gallbladder smooth muscle. All m-cholinoceptor antagonists examined, displace...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139061
更新日期:1993-06-01 00:00:00
abstract::The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138189
更新日期:1986-01-01 00:00:00