Release of a common source of intracellular Ca2+ by alpha-adrenergic agonists and dinitrophenol in rat liver slices.

abstract：:Erythrocytes can take up amino acids from the blood by using a variety of transport systems. GLYT is a key transport protein in the plasma membrane responsible for the Na(2+)-dependent uptake of glycine needed for glutathione biosynthesis. Certain cysteine-specific compounds, particularly mercuric chloride and 5,5'-di...

journal_title：Pharmacology

authors： McCormick SJ,Tunnicliff G

更新日期：2004-03-01 00:00:00

abstract：:Angiotensin II (ANG II) is a potent vasoconstrictor in most vascular beds. We studied the role of cyclooxygenase products and/or endothelium-derived relaxing factor (EDRF) in modulating the pressor response to ANG II in the isolated, blood perfused dog lung. ANG II was given as a bolus dose of 2, 4 and 8 micrograms be...

journal_title：Pharmacology

authors： el-Kashef HA,Ehrhart IC,Hofman WF

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...

journal_title：Pharmacology

authors： Li TP,Sun SW,Xiong GZ,Qiu F,Yang DM,Sun SY,Xie XJ,Liao DF,Chen JX,Tuo QH

更新日期：2020-07-21 00:00:00

abstract：AIM:This study investigates factors influencing the severity of opiate withdrawal symptoms, focusing on the relationship between methadone dose and withdrawal severity among opiate-dependent in-patients receiving methadone detoxification. METHODS:The sample comprised 48 opiate-dependent patients admitted to a speciali...

journal_title：Pharmacology

authors： Glasper A,Gossop M,de Wet C,Reed L,Bearn J

更新日期：2008-01-01 00:00:00

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

journal_title：Pharmacology

authors： Al-Rawi MB,Aleisa AM,Khattab MM

更新日期：2008-01-01 00:00:00

abstract：:The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-...

journal_title：Pharmacology

authors： Bomfim JH,de Godoy MA,Giglio JR,de Oliveira AM,Arantes EC

更新日期：2005-03-01 00:00:00

abstract：:Feeding a thiamin-deficient diet to male and female rats for 3 weeks alters the mixed function oxidases responsible for metabolizing benzo(a)pyrene and enhances the response of these enzymes to induction by phenobarbital or 3-methylcholanthrene. The caloric restriction observed in thiamin deprivation may be partially ...

journal_title：Pharmacology

authors： Wade AE,Bunce OR,Harley W,Baker MT,Holmes D

更新日期：1984-01-01 00:00:00

abstract：:The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...

journal_title：Pharmacology

authors： Abalo R,Vera G,López-Pérez AE,Martínez-Villaluenga M,Martín-Fontelles MI

更新日期：2012-01-01 00:00:00

abstract：AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...

journal_title：Pharmacology

authors： Chen FS,Satoh Y,Ide Y,Sugano T,Iimura M,Momose Y,Tsuchida K,Tagami M

更新日期：2012-01-01 00:00:00

abstract：:The influence of repeated administration of histamine on lithium-induced state dependency has been investigated. A single-trial step-down inhibitory avoidance task was used to assess memory in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg), immediately after training (post-training),...

journal_title：Pharmacology

authors： Zarrindast MR,Parsaei L,Ahmadi S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

journal_title：Pharmacology

authors： Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

更新日期：2015-01-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：:We examined the effects of cannabinoid receptor agonists on (45)Ca(2+) uptake in rat brain synaptosomes. A cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2) dose-dependently inhibited (45)Ca(2+) uptake in rat s...

journal_title：Pharmacology

authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

更新日期：2006-01-01 00:00:00

abstract：:The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...

journal_title：Pharmacology

authors： Mitsos SE,Jolly SR,Lucchesi BR

更新日期：1985-01-01 00:00:00

abstract：:We investigated a possible alteration in the ability of leukocytes to produce reactive oxygen species by stobadine, a pyridoindole antioxidant, in streptozotocin-diabetic rats. The production of free radicals from whole blood was assessed by luminol-enhanced chemiluminescence after stimulation by phorbol myristate ace...

journal_title：Pharmacology

authors： Demiryürek AT,Karasu C,Stefek M,Stolc S

更新日期：2004-01-01 00:00:00

abstract：:In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...

journal_title：Pharmacology

authors： Trivedi CJ,Balaraman R,Majithiya JB,Bothara SB

更新日期：2006-01-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...

journal_title：Pharmacology

authors： Grgurevich S,Greene FE

更新日期：1995-06-01 00:00:00

abstract：:Hamster renal cytosol binds [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with high specificity. Sucrose density gradient centrifugation revealed two binding entities- one with a low sedimentation coefficient of 4-5 S which was displaced by neither TCDD nor other polycyclic aromatic hydrocarbons (PAHs) and another w...

journal_title：Pharmacology

authors： Kurl RN,Loring JM,Villee CA

更新日期：1985-01-01 00:00:00

abstract：:Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidi...

journal_title：Pharmacology

authors： Antoine MH,Herchuelz A,Lebrun P

更新日期：1992-01-01 00:00:00

abstract：:DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...

journal_title：Pharmacology

authors： Fregly MJ,Kelleher DL,Williams CM

更新日期：1979-01-01 00:00:00

abstract：:delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...

journal_title：Pharmacology

authors： Sofia RD,Diamantis W,Harrison JE,Melton J

更新日期：1978-01-01 00:00:00

abstract：:Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue. In the present study, canine coronary arterial rings were incubated with various treatments and exposed to 5HT (4 X 10(-7) M) and anoxia (95% N2 and 5% CO2). Developed tension was increased by 250 +/- ...

journal_title：Pharmacology

authors： Barrett JA,DePaul Lynch V,Balkon J,Smith RD,Wolf PS

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic human corpus cavernosum (HCC) tissues. METHODS:HCC tissues were obtained from 12 patients. Th...

journal_title：Pharmacology

authors： Murat N,Soner BC,Demir O,Esen A,Gidener S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...

journal_title：Pharmacology

authors： Wang T,Ge S,Xiong W,Zhou P,Cang J,Xue Z

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...

journal_title：Pharmacology

authors： Fitch R,Da Cunha V,Kauser K,Dole W,Parkinson J,Vergona R,Sullivan ME,Wang YX

更新日期：2001-01-01 00:00:00

abstract：:Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...

journal_title：Pharmacology

authors： Ertunc M,Sara Y,Korkusuz P,Onur R

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

journal_title：Pharmacology

authors： Noorbakhshnia M,Rahmani-Samani P,Eivani M

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：:A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significant...

journal_title：Pharmacology

authors： Momose T

更新日期：1983-01-01 00:00:00