Abstract:
:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 days) did not produce changes in rat oestrous cycle. The drug did not prevent or prolong the rate of conception or parturition, cause pre-term delivery and affect litter size. Birth weight and growth rate of pups from artemether-pretreated dams were within the normal range. Artemether (48-480 microg/ml) had no agonist effect on the isolated uterine smooth muscles of both non-pregnant and pregnant rats and guinea pigs. However, the drug (24- 240 microg/ml) reduced oxytocin-induced contraction of uterine tissues concentration-dependently, particularly in pregnant uteri.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Ejiofor JI,Kwanashie HO,Anuka JAdoi
10.1159/000094521subject
Has Abstractpub_date
2006-01-01 00:00:00pages
166-70issue
4eissn
0031-7012issn
1423-0313pii
94521journal_volume
77pub_type
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