Resistance in malignant tumors: can resistance assays optimize cytostatic chemotherapy?

abstract：:The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats was studied. TAC-101 at doses of 5 and 20 mg/kg clearly inhibited the development of CIA in terms of the swe...

journal_title：Pharmacology

authors： Miyagawa N,Homma T,Kagechika H,Shudo K,Nagai H

更新日期：2003-01-01 00:00:00

abstract：AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...

journal_title：Pharmacology

authors： Chen FS,Satoh Y,Ide Y,Sugano T,Iimura M,Momose Y,Tsuchida K,Tagami M

更新日期：2012-01-01 00:00:00

abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

journal_title：Pharmacology

authors： Al-Rawi MB,Aleisa AM,Khattab MM

更新日期：2008-01-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：:The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...

journal_title：Pharmacology

authors： Arkonac BM,Kersten JR,Wynsen JC,Nijhawan N,Warltier DC

更新日期：1996-02-01 00:00:00

abstract：:Tacrine (THA) selectively modulates binding of M1 ligands in an allosteric fashion causing positive cooperativity. The binding affinity of THA to M1 and M2 cholinoceptors is similar. It is therefore proposed that the allosteric selectivity of THA is a function of the binding site and not of THA itself. Its interaction...

journal_title：Pharmacology

authors： Szilagyi M,Lau WM

更新日期：1993-10-01 00:00:00

abstract：:Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...

journal_title：Pharmacology

authors： Mizrahi J,D'Orléans-Juste P,Caranikas S,Regoli D

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：:Cathinone, the active principle of Catha edulis (khat), shows long-lasting analgesic effects when the tail-flick test is used in rats. The involvement of monoamines, endogenous opioids and stress in this analgesic effect was tested. Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by r...

journal_title：Pharmacology

authors： Nencini P,Ahmed AM,Anania MC,Moscucci M,Paroli E

更新日期：1984-01-01 00:00:00

abstract：:The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...

journal_title：Pharmacology

authors： Batzri S,Harmon JW

更新日期：1986-01-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the pathogenesis of allergic diseases by controlling Th2 cell migration into inflamed tissues. The aim of the present study was to investigate the inhibitory effect of ...

journal_title：Pharmacology

authors： Sato T,Komai M,Iwase M,Kobayashi K,Tahara H,Ohshima E,Arai H,Miki I

更新日期：2009-01-01 00:00:00

abstract：:The mechanisms underlying the fade of the tetanic contraction induced by pancuronium were studied in vitro by means of myographical and electrophysiological techniques in the extensor digitorum longus muscle of the rat. Pancuronium (0.5 mumol/l) induced a complete fade of the tetanic contraction while leaving the twit...

journal_title：Pharmacology

authors： Gallacci M,Oliveira AC

更新日期：1994-10-01 00:00:00

abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...

journal_title：Pharmacology

authors： Marumo F,Nara Y

更新日期：1987-01-01 00:00:00

abstract：:The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...

journal_title：Pharmacology

authors： Mitsos SE,Jolly SR,Lucchesi BR

更新日期：1985-01-01 00:00:00

abstract：:The purpose of these studies was to evaluate the effects of the peptidoleukotriene (LT) receptor antagonist, ICI 198615, on the vasopressor responses produced by LTC4, LTD4 and LTE4. Conscious, normotensive rats were prepared with arterial and venous catheters for measurement of changes in arterial blood pressure and ...

journal_title：Pharmacology

authors： Smith EF 3rd,Slivjak MJ

更新日期：1990-01-01 00:00:00

abstract：:Effects of schisandrin B enantiomer ((+)Sch B and (-)Sch B) treatment on the reduced cellular glutathione (GSH) level and susceptibility to menadione-induced toxicity were investigated and compared in AML12 hepatocytes. (+)Sch B or (-)Sch B treatment at 6.25 micromol/l produced a time-dependent change in cellular GSH ...

journal_title：Pharmacology

authors： Chiu PY,Leung HY,Poon MK,Mak DH,Ko KM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...

journal_title：Pharmacology

authors： Siddiqui AJ,Gustafsson T,Sylven C,Crisby M

更新日期：2014-01-01 00:00:00

abstract：:Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When N...

journal_title：Pharmacology

authors： Marshall CE,Dadmarz M,Hofford JM,Gottheil E,Vogel WH

更新日期：2003-03-01 00:00:00

abstract：:Neurochemical and neuropharmacological investigations with four ergot derivatives reveal differential pharmacodynamic effects of these compounds. Bromocriptine and CM 29-712 showed actions typical of postsynaptic dopamine receptor stimulants, in particular in the extrapyramidal system. CM 29-712 proved to be more pote...

journal_title：Pharmacology

authors： Vigouret JM,Bürki HR,Jaton AL,Züger PE,Loew DM

更新日期：1978-01-01 00:00:00

abstract：:Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is signif...

journal_title：Pharmacology

authors： Videla LA,Fernández V,Valenzuela A,Ugarte G

更新日期：1981-01-01 00:00:00

abstract：:Nabumetone is a nonsteroidal anti-inflammatory (NSAI) drug which is known to cause less gastrointestinal damage than other NSAI drugs. This study was performed to evaluate whether nabumetone treatment might alter the vascular aberrations related to inflammation in a rat model of adjuvant-induced arthritis. Nabumetone ...

journal_title：Pharmacology

authors： Ulker S,Onal A,Hatip FB,Sürücü A,Alkanat M,Koşay S,Evinç A

更新日期：2000-04-01 00:00:00

abstract：:A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the prep...

journal_title：Pharmacology

authors： Iida S,Itoh Y,Moriwaki K

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...

journal_title：Pharmacology

authors： Bourdon F,Lecoeur M,Lebègue N,Gressier B,Luyckx M,Odou P,Dine T,Goossens JF,Kambia N

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...

journal_title：Pharmacology

authors： Li TP,Sun SW,Xiong GZ,Qiu F,Yang DM,Sun SY,Xie XJ,Liao DF,Chen JX,Tuo QH

更新日期：2020-07-21 00:00:00

abstract：:L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxif...

journal_title：Pharmacology

authors： Pierrefiche G,Reynier M,Laborit H

更新日期：1993-01-01 00:00:00

abstract：:A multicenter, placebo-controlled, double-dummy, randomized, parallel-group, double-blind study was conducted to verify the hypothesis of noninferiority for single-dose administration of zaltoprofen 160 mg, a nonsteroidal anti-inflammatory drug, compared with loxoprofen sodium 60 mg (loxoprofen), in terms of antipyret...

journal_title：Pharmacology

authors： Azuma A,Kudoh S,Nakashima M,Nagatake T

更新日期：2011-01-01 00:00:00

abstract：:Based on their anabolic properties in skeletal muscles, beta-adrenergic agonists are of interest as potential countermeasures to microgravity-induced skeletal muscle atrophy. The levels of clenbuterol (Cb), a beta(2)-adrenergic agonist, in both plasma and skeletal muscle were higher in hindlimb-suspended rats than in ...

journal_title：Pharmacology

authors： von Deutsch DA,Abukhalaf IK,Wineski LE,Roper RR,Aboul-Enein HY,Paulsen DF,Potter DE

更新日期：2002-05-01 00:00:00

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：:A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase. Phenylbutazone, aminopyrine, 1,3-diphenylisobenzofuran, paracetamol, p-aminophenol, p-phenetidine and other o- and m-substituted aminop...

journal_title：Pharmacology

authors： Baumann J,von Bruchhausen F,Wurm G

更新日期：1983-01-01 00:00:00

abstract：:The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious dogs and were compared with the effects of porcine motilin (pMTL), EM-523 and EM-574. In the interdigestive state, intravenous and oral administration of mitemcin...

journal_title：Pharmacology

authors： Ozaki K,Yogo K,Sudo H,Onoma M,Kamei K,Akima M,Koga H,Itoh Z,Omura S,Takanashi H

更新日期：2007-01-01 00:00:00