Abstract:
:Based on their anabolic properties in skeletal muscles, beta-adrenergic agonists are of interest as potential countermeasures to microgravity-induced skeletal muscle atrophy. The levels of clenbuterol (Cb), a beta(2)-adrenergic agonist, in both plasma and skeletal muscle were higher in hindlimb-suspended rats than in their nonsuspended Cb-treated controls. Cb treatment was shown to help maintain the body weight in suspended rats, while reducing the amount of mesenteric fat. However, hindlimb suspension attenuated Cb's lipolytic effects. In skeletal muscle, the magnitude of response to unloading and Cb treatment followed a general regional pattern and was muscle and type specific. The highest magnitude of response to unloading was in predominantly slow-twitch muscles, and the least responsive were the predominately fast-twitch muscles.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
von Deutsch DA,Abukhalaf IK,Wineski LE,Roper RR,Aboul-Enein HY,Paulsen DF,Potter DEdoi
10.1159/000056184subject
Has Abstractpub_date
2002-05-01 00:00:00pages
38-48issue
1eissn
0031-7012issn
1423-0313pii
56184journal_volume
65pub_type
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